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Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:RPL13A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000133771‹1 – ›13760S ribosomal protein L13aAdd BLAST›137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55CitrullineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei136CitrullineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-73 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ95307.
PeptideAtlasiQ95307.
PRIDEiQ95307.

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003433.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3204. Eukaryota.
COG0102. LUCA.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiQ95307.

Family and domain databases

CDDicd00392. Ribosomal_L13. 1 hit.
Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13. 1 hit.
InterProiView protein in InterPro
IPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR005755. Ribosomal_L13_euk/arc.
IPR036899. Ribosomal_L13_sf.
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiView protein in Pfam
PF00572. Ribosomal_L13. 1 hit.
PIRSFiPIRSF002181. Ribosomal_L13. 1 hit.
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiView protein in PROSITE
PS00783. RIBOSOMAL_L13. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q95307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QVLVLDGRGH LLGRLAAIVA KQVLLGRKVV VVRCEGINIS GNFYRNKLKY
60 70 80 90 100
LAFLRKRMNT NPSRGPYHFR APSRIFWRTV RGMLPHKTKR GQAALDRLKV
110 120 130
FDGIPPPYDK KKRMVVPAAL KVVRLKLTGK FXYLGRL
Length:137
Mass (Da):15,674
Last modified:November 1, 1997 - v2
Checksum:iC5245A7696CD0217
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti16A → V in CAB03544 (Ref. 1) Curated1
Non-terminal residuei1371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81152 mRNA. Translation: CAB03544.1.
Z84103 mRNA. Translation: CAB06326.1.
UniGeneiSsc.17024.
Ssc.27927.
Ssc.63662.

Similar proteinsi

Entry informationi

Entry nameiRL13A_PIG
AccessioniPrimary (citable) accession number: Q95307
Secondary accession number(s): P79320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families