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Protein

Growth hormone secretagogue receptor type 1

Gene

GHSR

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone secretagogue receptor type 1
Short name:
GHS-R
Alternative name(s):
GH-releasing peptide receptor
Short name:
GHRP
Ghrelin receptor
Gene namesi
Name:GHSR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 66Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini67 – 72CytoplasmicSequence analysis6
Transmembranei73 – 96Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini97 – 117ExtracellularSequence analysisAdd BLAST21
Transmembranei118 – 139Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini140 – 162CytoplasmicSequence analysisAdd BLAST23
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 211ExtracellularSequence analysisAdd BLAST28
Transmembranei212 – 235Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini236 – 263CytoplasmicSequence analysisAdd BLAST28
Transmembranei264 – 285Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini286 – 302ExtracellularSequence analysisAdd BLAST17
Transmembranei303 – 326Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini327 – 366CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694811 – 366Growth hormone secretagogue receptor type 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95254.

Expressioni

Tissue specificityi

Pituitary and hypothalamus.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012525.

Chemistry databases

BindingDBiQ95254.

Structurei

3D structure databases

ProteinModelPortaliQ95254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiQ95254.
KOiK04284.
OMAiDTNECRA.
OrthoDBiEOG091G09KB.
TreeFamiTF332184.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1A (identifier: Q95254-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWNATPSEEP GPNLTLPDLG WDAPPENDSL VEELLPLFPT PLLAGVTATC
60 70 80 90 100
VALFVVGIAG NLLTMLVVSR FREMRTTTNL YLSSMAFSDL LIFLCMPLDL
110 120 130 140 150
FRLWQYRPWN LGNLLCKLFQ FVSESCTYAT VLTITALSVE RYFAICFPLR
160 170 180 190 200
AKVVVTKGRV KLVILVIWAV AFCSAGPIFV LVGVEHDNGT DPRDTNECRA
210 220 230 240 250
TEFAVRSGLL TVMVWVSSVF FFLPVFCLTV LYSLIGRKLW RRKRGEAAVG
260 270 280 290 300
SSLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSL EPGSVEIAQI
310 320 330 340 350
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFKLLGF EPFSQRKLST
360
LKDESSRAWT ESSINT
Length:366
Mass (Da):41,195
Last modified:February 1, 1997 - v1
Checksum:i2C850B3EF61B7C1C
GO
Isoform 1B (identifier: Q95254-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-289: AVVVFAFILCWLPFHVGRYLFSKS → GGSQCALELSLPGPLHSSCLFSSP
     290-366: Missing.

Show »
Length:289
Mass (Da):32,047
Checksum:iBB248CB89687D813
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001918266 – 289AVVVF…LFSKS → GGSQCALELSLPGPLHSSCL FSSP in isoform 1B. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_001919290 – 366Missing in isoform 1B. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60178 mRNA. Translation: AAC48630.1.
U60180 mRNA. Translation: AAC48631.1.
RefSeqiNP_999345.1. NM_214180.1. [Q95254-1]
UniGeneiSsc.16107.

Genome annotation databases

EnsembliENSSSCT00000012865; ENSSSCP00000012525; ENSSSCG00000011754. [Q95254-2]
GeneIDi397372.
KEGGissc:397372.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60178 mRNA. Translation: AAC48630.1.
U60180 mRNA. Translation: AAC48631.1.
RefSeqiNP_999345.1. NM_214180.1. [Q95254-1]
UniGeneiSsc.16107.

3D structure databases

ProteinModelPortaliQ95254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012525.

Chemistry databases

BindingDBiQ95254.
ChEMBLiCHEMBL2224.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ95254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012865; ENSSSCP00000012525; ENSSSCG00000011754. [Q95254-2]
GeneIDi397372.
KEGGissc:397372.

Organism-specific databases

CTDi2693.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiQ95254.
KOiK04284.
OMAiDTNECRA.
OrthoDBiEOG091G09KB.
TreeFamiTF332184.

Enzyme and pathway databases

ReactomeiR-SSC-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHSR_PIG
AccessioniPrimary (citable) accession number: Q95254
Secondary accession number(s): Q95255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.