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Protein

Interleukin-15

Gene

IL15

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:IL15
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 4819Sequence analysisPRO_0000015401Add
BLAST
Chaini49 – 162114Interleukin-15PRO_0000015402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 133By similarity
Disulfide bondi90 ↔ 136By similarity
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95253.
PRIDEiQ95253.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009657.

Structurei

3D structure databases

ProteinModelPortaliQ95253.
SMRiQ95253. Positions 48-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5D. Eukaryota.
ENOG41119SX. LUCA.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiQ95253.
KOiK05433.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILKPCLRS TCIQCYLCLL LNSHFLTEDG IHVFILGCIS AGLPKTEATW
60 70 80 90 100
QHVISDLKKI EDLIRSIHMD ATLYTESDAH PNCKVTAMKC FLLELRVILQ
110 120 130 140 150
ESRNSDISDT VENLIILANS SLSSIEYKTE SGCKECEELE EKNINEFLKS
160
FIHIVQMFIN PS
Length:162
Mass (Da):18,437
Last modified:February 1, 1997 - v1
Checksum:i7EF7992391883446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58142 mRNA. Translation: AAB72031.1.
DQ658181 mRNA. Translation: ABF82250.1.
RefSeqiNP_999555.1. NM_214390.1.
UniGeneiSsc.8833.

Genome annotation databases

GeneIDi397683.
KEGGissc:397683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58142 mRNA. Translation: AAB72031.1.
DQ658181 mRNA. Translation: ABF82250.1.
RefSeqiNP_999555.1. NM_214390.1.
UniGeneiSsc.8833.

3D structure databases

ProteinModelPortaliQ95253.
SMRiQ95253. Positions 48-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009657.

Proteomic databases

PaxDbiQ95253.
PRIDEiQ95253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397683.
KEGGissc:397683.

Organism-specific databases

CTDi3600.

Phylogenomic databases

eggNOGiENOG410IZ5D. Eukaryota.
ENOG41119SX. LUCA.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiQ95253.
KOiK05433.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of cDNA encoding porcine interleukin-15."
    Canals A., Grimm D.R., Gasbarre L.C., Lunney J.K., Zarlenga D.S.
    Gene 195:337-339(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "Cloning and sequencing of porcine IL-15."
    Zheng L.-L., Cui B.-A., Fang Z.-Y.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL15_PIG
AccessioniPrimary (citable) accession number: Q95253
Secondary accession number(s): Q195F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 17, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.