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Protein

Membrane-associated progesterone receptor component 1

Gene

PGRMC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

ReactomeiR-SSC-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Short name:
mPRBy similarity
Gene namesi
Name:PGRMC1
Synonyms:PGRMC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 24LumenalSequence analysisAdd BLAST23
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 194CytoplasmicSequence analysisAdd BLAST151

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001217412 – 194Membrane-associated progesterone receptor component 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei73PhosphothreonineBy similarity1
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95250.
PeptideAtlasiQ95250.
PRIDEiQ95250.

PTM databases

iPTMnetiQ95250.

Expressioni

Gene expression databases

BgeeiENSSSCG00000012625.
ExpressionAtlasiQ95250. differential.
GenevisibleiQ95250. SS.

Interactioni

Subunit structurei

Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013423.

Structurei

3D structure databases

ProteinModelPortaliQ95250.
SMRiQ95250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 170Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 106 and 130.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ95250.
KOiK17278.
OMAiEWETQFT.
OrthoDBiEOG091G0PXT.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVAATG ADPSELEGGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PAASDSDDDE PPPLPRLKRR DFTPAELRRF DGVQDPRILM AINGKVFDVT
110 120 130 140 150
KGRKFYGPEG PYGVFAGRDA SRGLATFCLD KEALKDEYDD LSDLTPAQQE
160 170 180 190
TLNDWDSQFT FKYHHVGKLL KEGEEPTVYS DEEEPKDESA RKND
Length:194
Mass (Da):21,609
Last modified:January 23, 2007 - v3
Checksum:iA852E79E5F5C74D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99714 mRNA. Translation: CAA68050.1.
PIRiJC5260.
RefSeqiNP_999076.1. NM_213911.1.
UniGeneiSsc.9819.

Genome annotation databases

EnsembliENSSSCT00000013804; ENSSSCP00000013423; ENSSSCG00000012625.
GeneIDi396946.
KEGGissc:396946.

Similar proteinsi

Entry informationi

Entry nameiPGRC1_PIG
AccessioniPrimary (citable) accession number: Q95250
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families