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Protein

Membrane-associated progesterone receptor component 1

Gene

PGRMC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for progesterone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Gene namesi
Name:PGRMC1
Synonyms:PGRMC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2423LumenalSequence analysisAdd
BLAST
Transmembranei25 – 4319HelicalSequence analysisAdd
BLAST
Topological domaini44 – 194151CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 194193Membrane-associated progesterone receptor component 1PRO_0000121741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei73 – 731PhosphothreonineBy similarity
Modified residuei180 – 1801PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95250.

Expressioni

Gene expression databases

GenevisibleiQ95250. SS.

Interactioni

Subunit structurei

Heterodimer or heterotrimer.Curated

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013423.

Structurei

3D structure databases

ProteinModelPortaliQ95250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 170100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 106 and 130.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ95250.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG7KWSKJ.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVAATG ADPSELEGGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PAASDSDDDE PPPLPRLKRR DFTPAELRRF DGVQDPRILM AINGKVFDVT
110 120 130 140 150
KGRKFYGPEG PYGVFAGRDA SRGLATFCLD KEALKDEYDD LSDLTPAQQE
160 170 180 190
TLNDWDSQFT FKYHHVGKLL KEGEEPTVYS DEEEPKDESA RKND
Length:194
Mass (Da):21,609
Last modified:January 23, 2007 - v3
Checksum:iA852E79E5F5C74D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99714 mRNA. Translation: CAA68050.1.
PIRiJC5260.
RefSeqiNP_999076.1. NM_213911.1.
UniGeneiSsc.9819.

Genome annotation databases

EnsembliENSSSCT00000013804; ENSSSCP00000013423; ENSSSCG00000012625.
GeneIDi396946.
KEGGissc:396946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99714 mRNA. Translation: CAA68050.1.
PIRiJC5260.
RefSeqiNP_999076.1. NM_213911.1.
UniGeneiSsc.9819.

3D structure databases

ProteinModelPortaliQ95250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013423.

Proteomic databases

PaxDbiQ95250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000013804; ENSSSCP00000013423; ENSSSCG00000012625.
GeneIDi396946.
KEGGissc:396946.

Organism-specific databases

CTDi10857.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ95250.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG7KWSKJ.
TreeFamiTF314562.

Gene expression databases

GenevisibleiQ95250. SS.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Full-length cDNA sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells."
    Falkenstein E., Meyer C., Eisen C., Scriba P.C., Wehling M.
    Biochem. Biophys. Res. Commun. 229:86-89(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Vascular smooth muscle.
  2. "Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes."
    Meyer C., Schmid R., Scriba P.C., Wehling M.
    Eur. J. Biochem. 239:726-731(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21, CHARACTERIZATION.
    Tissue: Liver.

Entry informationi

Entry nameiPGRC1_PIG
AccessioniPrimary (citable) accession number: Q95250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.