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Q95221

- IP6K2_RABIT

UniProt

Q95221 - IP6K2_RABIT

Protein

Inositol hexakisphosphate kinase 2

Gene

IP6K2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.2 Publications

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 2
    Alternative name(s):
    P(i)-uptake stimulator
    Short name:
    PiUS
    Gene namesi
    Name:IP6K2
    Synonyms:IHPK2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 9

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Inositol hexakisphosphate kinase 2PRO_0000066879Add
    BLAST

    Expressioni

    Tissue specificityi

    Detected in kidney, intestine, liver and heart.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000018629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 2239Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    GeneTreeiENSGT00390000014381.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    OrthoDBiEOG747PHX.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95221-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAFRAMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLIPREHQ    50
    FYETLPAEMR KFTPQYKGVV SVCFEEDEDR NLCLIAYPLK GDHGTVDLVD 100
    NSDCEPKSKV LRWTTKKHHV LESEKTPKEW VRQHRKEEKM KSHKLEEEFE 150
    WLKKSEVLYY SVEKKGNVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY 200
    KFILLENLTS RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV 250
    IGVRVCGMQV YQAGSGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 300
    ELLGPVLKKL AELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVALDSDAED 350
    LEDLSEESAD ESAGAYAYKP IGASSVDVRM IDFAHTTCRL YGEDSVVHEG 400
    QDAGYIFGLQ SLIDIVTEIS EDSGE 425
    Length:425
    Mass (Da):48,967
    Last modified:February 1, 1997 - v1
    Checksum:i4FC714618FEFD7B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74297 mRNA. Translation: AAB49289.1.
    RefSeqiNP_001075846.1. NM_001082377.1.
    UniGeneiOcu.2563.

    Genome annotation databases

    EnsembliENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
    ENSOCUT00000025680; ENSOCUP00000018629; ENSOCUG00000012420.
    GeneIDi100009233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74297 mRNA. Translation: AAB49289.1 .
    RefSeqi NP_001075846.1. NM_001082377.1.
    UniGenei Ocu.2563.

    3D structure databases

    ProteinModelPortali Q95221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000018629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000012420 ; ENSOCUP00000010692 ; ENSOCUG00000012420 .
    ENSOCUT00000025680 ; ENSOCUP00000018629 ; ENSOCUG00000012420 .
    GeneIDi 100009233.

    Organism-specific databases

    CTDi 51447.

    Phylogenomic databases

    eggNOGi NOG274869.
    GeneTreei ENSGT00390000014381.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    OrthoDBi EOG747PHX.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes."
      Norbis F., Boll M., Stange G., Markovich D., Verrey F., Biber J., Murer H.
      J. Membr. Biol. 156:19-24(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: New Zealand.
      Tissue: Small intestine.
    2. "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase."
      Schell M.J., Letcher A.J., Brearley C.A., Biber J., Murer H., Irvine R.F.
      FEBS Lett. 461:169-172(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiIP6K2_RABIT
    AccessioniPrimary (citable) accession number: Q95221
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3