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Q95221

- IP6K2_RABIT

UniProt

Q95221 - IP6K2_RABIT

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Protein
Inositol hexakisphosphate kinase 2
Gene
IP6K2, IHPK2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.2 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  3. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  5. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:IP6K2
Synonyms:IHPK2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 9

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Inositol hexakisphosphate kinase 2
PRO_0000066879Add
BLAST

Expressioni

Tissue specificityi

Detected in kidney, intestine, liver and heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018629.

Structurei

3D structure databases

ProteinModelPortaliQ95221.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2239Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
OrthoDBiEOG747PHX.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95221-1 [UniParc]FASTAAdd to Basket

« Hide

MSPAFRAMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLIPREHQ    50
FYETLPAEMR KFTPQYKGVV SVCFEEDEDR NLCLIAYPLK GDHGTVDLVD 100
NSDCEPKSKV LRWTTKKHHV LESEKTPKEW VRQHRKEEKM KSHKLEEEFE 150
WLKKSEVLYY SVEKKGNVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY 200
KFILLENLTS RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV 250
IGVRVCGMQV YQAGSGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 300
ELLGPVLKKL AELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVALDSDAED 350
LEDLSEESAD ESAGAYAYKP IGASSVDVRM IDFAHTTCRL YGEDSVVHEG 400
QDAGYIFGLQ SLIDIVTEIS EDSGE 425
Length:425
Mass (Da):48,967
Last modified:February 1, 1997 - v1
Checksum:i4FC714618FEFD7B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74297 mRNA. Translation: AAB49289.1.
RefSeqiNP_001075846.1. NM_001082377.1.
UniGeneiOcu.2563.

Genome annotation databases

EnsembliENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
ENSOCUT00000025680; ENSOCUP00000018629; ENSOCUG00000012420.
GeneIDi100009233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74297 mRNA. Translation: AAB49289.1 .
RefSeqi NP_001075846.1. NM_001082377.1.
UniGenei Ocu.2563.

3D structure databases

ProteinModelPortali Q95221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000018629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000012420 ; ENSOCUP00000010692 ; ENSOCUG00000012420 .
ENSOCUT00000025680 ; ENSOCUP00000018629 ; ENSOCUG00000012420 .
GeneIDi 100009233.

Organism-specific databases

CTDi 51447.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOGENOMi HOG000007418.
HOVERGENi HBG052140.
OrthoDBi EOG747PHX.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes."
    Norbis F., Boll M., Stange G., Markovich D., Verrey F., Biber J., Murer H.
    J. Membr. Biol. 156:19-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: New Zealand.
    Tissue: Small intestine.
  2. "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase."
    Schell M.J., Letcher A.J., Brearley C.A., Biber J., Murer H., Irvine R.F.
    FEBS Lett. 461:169-172(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIP6K2_RABIT
AccessioniPrimary (citable) accession number: Q95221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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