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Protein

Inositol hexakisphosphate kinase 2

Gene

IP6K2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.2 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:IP6K2
Synonyms:IHPK2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Inositol hexakisphosphate kinase 2PRO_0000066879Add
BLAST

Expressioni

Tissue specificityi

Detected in kidney, intestine, liver and heart.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ95221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 2239Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ95221.
KOiK07756.
OrthoDBiEOG747PHX.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRAMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLIPREHQ
60 70 80 90 100
FYETLPAEMR KFTPQYKGVV SVCFEEDEDR NLCLIAYPLK GDHGTVDLVD
110 120 130 140 150
NSDCEPKSKV LRWTTKKHHV LESEKTPKEW VRQHRKEEKM KSHKLEEEFE
160 170 180 190 200
WLKKSEVLYY SVEKKGNVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY
210 220 230 240 250
KFILLENLTS RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV
260 270 280 290 300
IGVRVCGMQV YQAGSGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR
310 320 330 340 350
ELLGPVLKKL AELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVALDSDAED
360 370 380 390 400
LEDLSEESAD ESAGAYAYKP IGASSVDVRM IDFAHTTCRL YGEDSVVHEG
410 420
QDAGYIFGLQ SLIDIVTEIS EDSGE
Length:425
Mass (Da):48,967
Last modified:February 1, 1997 - v1
Checksum:i4FC714618FEFD7B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74297 mRNA. Translation: AAB49289.1.
RefSeqiNP_001075846.1. NM_001082377.1.
UniGeneiOcu.2563.

Genome annotation databases

EnsembliENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
ENSOCUT00000025680; ENSOCUP00000018629; ENSOCUG00000012420.
GeneIDi100009233.
KEGGiocu:100009233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74297 mRNA. Translation: AAB49289.1.
RefSeqiNP_001075846.1. NM_001082377.1.
UniGeneiOcu.2563.

3D structure databases

ProteinModelPortaliQ95221.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
ENSOCUT00000025680; ENSOCUP00000018629; ENSOCUG00000012420.
GeneIDi100009233.
KEGGiocu:100009233.

Organism-specific databases

CTDi51447.

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ95221.
KOiK07756.
OrthoDBiEOG747PHX.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes."
    Norbis F., Boll M., Stange G., Markovich D., Verrey F., Biber J., Murer H.
    J. Membr. Biol. 156:19-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: New Zealand.
    Tissue: Small intestine.
  2. "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase."
    Schell M.J., Letcher A.J., Brearley C.A., Biber J., Murer H., Irvine R.F.
    FEBS Lett. 461:169-172(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIP6K2_RABIT
AccessioniPrimary (citable) accession number: Q95221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.