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Protein

Inositol hexakisphosphate kinase 2

Gene

IP6K2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport.2 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 2 (EC:2.7.4.21)
Short name:
InsP6 kinase 2
Alternative name(s):
P(i)-uptake stimulator
Short name:
PiUS
Gene namesi
Name:IP6K2
Synonyms:IHPK2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668791 – 425Inositol hexakisphosphate kinase 2Add BLAST425

Expressioni

Tissue specificityi

Detected in kidney, intestine, liver and heart.1 Publication

Gene expression databases

BgeeiENSOCUG00000012420.

Structurei

3D structure databases

ProteinModelPortaliQ95221.
SMRiQ95221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 223Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ95221.
KOiK07756.
OMAiLRWTNKK.
OrthoDBiEOG091G0JK2.

Family and domain databases

InterProiView protein in InterPro
IPR005522. IPK.
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiView protein in Pfam
PF03770. IPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q95221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAFRAMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLIPREHQ
60 70 80 90 100
FYETLPAEMR KFTPQYKGVV SVCFEEDEDR NLCLIAYPLK GDHGTVDLVD
110 120 130 140 150
NSDCEPKSKV LRWTTKKHHV LESEKTPKEW VRQHRKEEKM KSHKLEEEFE
160 170 180 190 200
WLKKSEVLYY SVEKKGNVSS QLKHYNPWSM KCHQQQLQRM KENAKHRNQY
210 220 230 240 250
KFILLENLTS RYEVPCVLDL KMGTRQHGDD ASEEKAANQI RKCQQSTSAV
260 270 280 290 300
IGVRVCGMQV YQAGSGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR
310 320 330 340 350
ELLGPVLKKL AELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVALDSDAED
360 370 380 390 400
LEDLSEESAD ESAGAYAYKP IGASSVDVRM IDFAHTTCRL YGEDSVVHEG
410 420
QDAGYIFGLQ SLIDIVTEIS EDSGE
Length:425
Mass (Da):48,967
Last modified:February 1, 1997 - v1
Checksum:i4FC714618FEFD7B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74297 mRNA. Translation: AAB49289.1.
RefSeqiNP_001075846.1. NM_001082377.1.
UniGeneiOcu.2563.

Genome annotation databases

EnsembliENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
ENSOCUT00000025680; ENSOCUP00000018629; ENSOCUG00000012420.
GeneIDi100009233.
KEGGiocu:100009233.

Similar proteinsi

Entry informationi

Entry nameiIP6K2_RABIT
AccessioniPrimary (citable) accession number: Q95221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families