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Q95221 (IP6K2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 2
Short name=InsP6 kinase 2
EC=2.7.4.21
Alternative name(s):
P(i)-uptake stimulator
Short name=PiUS
Gene names
Name:IP6K2
Synonyms:IHPK2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na+-dependent phosphate cotransport. Ref.1 Ref.2

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown).

Subcellular location

Nucleus By similarity.

Tissue specificity

Detected in kidney, intestine, liver and heart. Ref.1

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Inositol hexakisphosphate kinase 2
PRO_0000066879

Regions

Region215 – 2239Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95221 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4FC714618FEFD7B5

FASTA42548,967
        10         20         30         40         50         60 
MSPAFRAMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLIPREHQ FYETLPAEMR 

        70         80         90        100        110        120 
KFTPQYKGVV SVCFEEDEDR NLCLIAYPLK GDHGTVDLVD NSDCEPKSKV LRWTTKKHHV 

       130        140        150        160        170        180 
LESEKTPKEW VRQHRKEEKM KSHKLEEEFE WLKKSEVLYY SVEKKGNVSS QLKHYNPWSM 

       190        200        210        220        230        240 
KCHQQQLQRM KENAKHRNQY KFILLENLTS RYEVPCVLDL KMGTRQHGDD ASEEKAANQI 

       250        260        270        280        290        300 
RKCQQSTSAV IGVRVCGMQV YQAGSGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR 

       310        320        330        340        350        360 
ELLGPVLKKL AELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVALDSDAED LEDLSEESAD 

       370        380        390        400        410        420 
ESAGAYAYKP IGASSVDVRM IDFAHTTCRL YGEDSVVHEG QDAGYIFGLQ SLIDIVTEIS 


EDSGE

« Hide

References

[1]"Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes."
Norbis F., Boll M., Stange G., Markovich D., Verrey F., Biber J., Murer H.
J. Membr. Biol. 156:19-24(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: New Zealand.
Tissue: Small intestine.
[2]"PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase."
Schell M.J., Letcher A.J., Brearley C.A., Biber J., Murer H., Irvine R.F.
FEBS Lett. 461:169-172(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U74297 mRNA. Translation: AAB49289.1.
RefSeqNP_001075846.1. NM_001082377.1.
UniGeneOcu.2563.

3D structure databases

ProteinModelPortalQ95221.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000018629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000012420; ENSOCUP00000010692; ENSOCUG00000012420.
GeneID100009233.

Organism-specific databases

CTD51447.

Phylogenomic databases

eggNOGNOG274869.
GeneTreeENSGT00390000014381.
HOGENOMHOG000007418.
HOVERGENHBG052140.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIP6K2_RABIT
AccessionPrimary (citable) accession number: Q95221
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 1, 1997
Last modified: April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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