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Protein

Cytochrome b561

Gene

CYB561

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi88 – 881Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi92 – 921Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi110 – 1101Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi122 – 1221Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi161 – 1611Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Topological domaini221 – 25232CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Cytochrome b561PRO_0000151031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 221202Cytochrome b561PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054164.
KOiK08360.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPASPAPA PGALPYYVAF SQLLGLTVVA MTGAWLGMYR GGIAWESALQ
60 70 80 90 100
FNVHPLCMVI GLVFLQGDAL LVYRVFRNEA KRTTKVLHGL LHVFAFVIAL
110 120 130 140 150
VGLVAVFEHH RKKGYADLYS LHSWCGILVF ALFFAQWLVG FSFFLFPGAS
160 170 180 190 200
FSLRSRYRPQ HVFFGAAIFL LSVATALLGL KEALLFELGT KYSTFEPEGV
210 220 230 240 250
LANVLGLLLA AFATVVLYIL TRADWKRPLQ AEEQALSMDF KTLTEGDSPS

SQ
Length:252
Mass (Da):27,745
Last modified:February 1, 1997 - v1
Checksum:i2DF5FD2C3F0D0C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88157 mRNA. Translation: BAA13548.1.
RefSeqiNP_001087259.1. NM_001093790.1.
UniGeneiOar.722.

Genome annotation databases

GeneIDi100048995.
KEGGioas:100048995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88157 mRNA. Translation: BAA13548.1.
RefSeqiNP_001087259.1. NM_001093790.1.
UniGeneiOar.722.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100048995.
KEGGioas:100048995.

Organism-specific databases

CTDi1534.

Phylogenomic databases

HOVERGENiHBG054164.
KOiK08360.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY561_SHEEP
AccessioniPrimary (citable) accession number: Q95204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.