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Q95198 (LYAM1_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name=LAM-1
Leukocyte-endothelial cell adhesion molecule 1
Short name=LECAM1
Lymph node homing receptor
CD_antigen=CD62L
Gene names
Name:SELL
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia By similarity.

Subunit structure

Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the selectin/LECAM family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 2 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 By similarity
Propeptide29 – 3810 By similarity
PRO_0000017477
Chain39 – 372334L-selectin
PRO_0000017478

Regions

Topological domain39 – 332294Extracellular Potential
Transmembrane333 – 35523Helical; Potential
Topological domain356 – 37217Cytoplasmic Potential
Domain55 – 155101C-type lectin
Domain156 – 19237EGF-like
Domain195 – 25662Sushi 1
Domain257 – 31862Sushi 2

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Disulfide bond57 ↔ 155 By similarity
Disulfide bond128 ↔ 147 By similarity
Disulfide bond160 ↔ 171 By similarity
Disulfide bond165 ↔ 180 By similarity
Disulfide bond182 ↔ 191 By similarity
Disulfide bond197 ↔ 241 By similarity
Disulfide bond227 ↔ 254 By similarity
Disulfide bond259 ↔ 303 By similarity
Disulfide bond289 ↔ 316 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95198 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 088D7DD5AC549D6D

FASTA37242,109
        10         20         30         40         50         60 
MIFPRKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSENPMNW QKARRFCREN 

        70         80         90        100        110        120 
YTDLVAIQNK AEIEYLEKTL PFSPSYYWIG IRKIGGIWTW VGTNKSLTQE AENWGDGEPN 

       130        140        150        160        170        180 
NKKNKEDCVE IYIKRKKDAG KWNDDACHKP KAALCYTASC QPWSCSGHGE CVEIINNYTC 

       190        200        210        220        230        240 
NCDVGYYGPQ CQFVIQCEPL EPPKLGTMDC THPLGDFSFS SQCAFNCSEG TNLTGIEETT 

       250        260        270        280        290        300 
CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FSSACTFSCS EGTELIGEKK 

       310        320        330        340        350        360 
TICESSGIWS NPNPICQKLD RSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK 

       370 
GKKSKKSMDD PY

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References

[1]"Cloning of the cDNA encoding L-selectin from nonhuman primates."
Budman J.I., Fu H., Johnson C.E., Thakur A.B., Berg E.L., Tsurushita N.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73730 mRNA. Translation: AAB18246.1.
RefSeqNP_001036228.1. NM_001042763.1.
UniGeneMmu.3394.

3D structure databases

ProteinModelPortalQ95198.
SMRQ95198. Positions 39-194.
ModBaseSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000021783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID701419.
KEGGmcc:701419.

Organism-specific databases

CTD6402.

Phylogenomic databases

eggNOGNOG258998.
HOGENOMHOG000236254.
HOVERGENHBG052375.
InParanoidQ95198.
KOK06495.
OrthoDBEOG4FFD22.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFPIRSF002421. L-selectin. 1 hit.
PRINTSPR00343. SELECTIN.
SMARTSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF56436. C-type_lectin_fold. 1 hit.
SSF57535. Complement_control_module. 2 hits.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio19959014.

Entry information

Entry nameLYAM1_MACMU
AccessionPrimary (citable) accession number: Q95198
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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