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Protein

Interleukin-6

Gene

IL6

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 208181Interleukin-6PRO_0000015581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 75By similarity
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Modified residuei78 – 781PhosphoserineBy similarity
Disulfide bondi98 ↔ 108By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ95181.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014219.

Structurei

3D structure databases

ProteinModelPortaliQ95181.
SMRiQ95181. Positions 44-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiQ95181.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSTSTVT PVAFSLGLLL VMATAFPTPL PLGEDETTSN GPLLTTADKT
60 70 80 90 100
KQHIKYILGK ISALKNEMCN NFSKCENSKE VLAENNLNLP KMAEKDGCFQ
110 120 130 140 150
SGFNQETCLM KITTGLSEFQ IYLEYLQNEF KGEKENIKTM QISTKVLVQI
160 170 180 190 200
LMQKMKNPEV TTPDPTAKSS LLAKLHSQNE WLKNTTTHLI LRSLEDFLQF

SLRAVRIM
Length:208
Mass (Da):23,325
Last modified:July 15, 1999 - v2
Checksum:iA62F4C234056BF66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 52LS → FF in AAB87703 (PubMed:11137120).Curated
Sequence conflicti8 – 81T → A in AAC04574 (Ref. 3) Curated
Sequence conflicti137 – 1371I → V in AAB62246 (Ref. 2) Curated
Sequence conflicti205 – 2051V → I in AAC04574 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64794 mRNA. Translation: AAB87703.1.
AF005227 mRNA. Translation: AAB62246.1.
AF041975 mRNA. Translation: AAC04574.1.
PIRiT09216.
RefSeqiNP_001075965.2. NM_001082496.2.
UniGeneiEca.12956.

Genome annotation databases

GeneIDi100034196.
KEGGiecb:100034196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64794 mRNA. Translation: AAB87703.1.
AF005227 mRNA. Translation: AAB62246.1.
AF041975 mRNA. Translation: AAC04574.1.
PIRiT09216.
RefSeqiNP_001075965.2. NM_001082496.2.
UniGeneiEca.12956.

3D structure databases

ProteinModelPortaliQ95181.
SMRiQ95181. Positions 44-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014219.

Proteomic databases

PaxDbiQ95181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034196.
KEGGiecb:100034196.

Organism-specific databases

CTDi3569.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiQ95181.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, sequencing, and expression of equine interleukin-6."
    Swiderski C.E., Sobol G., Lunn D.P., Horohov D.W.
    Vet. Immunol. Immunopathol. 77:213-220(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of equine interleukin-6."
    Leutenegger C.M., Huder J.B., von Rechenberg B., Akens M., Auer J.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and expression of equine interleukin-6."
    Lai A.C.K.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL6_HORSE
AccessioniPrimary (citable) accession number: Q95181
Secondary accession number(s): O19007, O46568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: January 20, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.