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Protein

Tight junction protein ZO-2

Gene

TJP2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in tight junctions and adherens junctions.

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-2
Alternative name(s):
Tight junction protein 2
Zona occludens protein 2
Zonula occludens protein 2
Gene namesi
Name:TJP2
Synonyms:ZO2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB-SubCell
  • cell surface Source: MGI
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945421 – 1174Tight junction protein ZO-2Add BLAST1174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei558PhosphotyrosineBy similarity1
Modified residuei686PhosphoserineBy similarity1
Modified residuei886PhosphoserineBy similarity1
Modified residuei889PhosphothreonineBy similarity1
Modified residuei897PhosphoserineBy similarity1
Modified residuei904PhosphoserineBy similarity1
Modified residuei909PhosphothreonineBy similarity1
Modified residuei917PhosphothreonineBy similarity1
Modified residuei950PhosphoserineBy similarity1
Modified residuei962PhosphoserineBy similarity1
Modified residuei970PhosphoserineBy similarity1
Modified residuei990PhosphoserineBy similarity1
Modified residuei1052PhosphoserineBy similarity1
Modified residuei1102PhosphotyrosineBy similarity1
Modified residuei1131PhosphoserineBy similarity1
Modified residuei1143PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ95168.
PRIDEiQ95168.

PTM databases

iPTMnetiQ95168.

Interactioni

Subunit structurei

Homodimer, and heterodimer with ZO1 and UBN1. Interacts with SCRIB (By similarity). Interacts with occludin and SAFB. Interaction with SAFB occurs in the nucleus. Interacts with USP53 (via the C-terminal region) (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ95168. 2 interactors.
STRINGi9615.ENSCAFP00000002794.

Structurei

3D structure databases

ProteinModelPortaliQ95168.
SMRiQ95168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 97PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini291 – 369PDZ 2PROSITE-ProRule annotationAdd BLAST79
Domaini493 – 574PDZ 3PROSITE-ProRule annotationAdd BLAST82
Domaini588 – 653SH3PROSITE-ProRule annotationAdd BLAST66
Domaini679 – 860Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1172 – 1174Interaction with SCRIBBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1146 – 1149Poly-Glu4

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ95168.
KOiK06098.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005419. ZO-2.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PRINTSiPR01597. ZONOCCLUDNS.
PR01599. ZONOCCLUDNS2.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q95168-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG
60 70 80 90 100
PADGLLQEND RVVMVNGTPM EDVLHSFAVQ QLRKSGKIAA IVVKRPRKVQ
110 120 130 140 150
LAPPQGSLPV DEDDRAFEVM DEFDGRSARS GYSERSRRSS HGGRSRSWED
160 170 180 190 200
SPERGRPHER AWSQERERSR GRSLERGLDH DDDYRRPRER SRGRSLERGL
210 220 230 240 250
DHDDDYGRPG ERSHGMSTDR GYDRGYDRGY DRGYDRTYSP EAEYGRRTQP
260 270 280 290 300
DARHAGSRSR SREHLRSRSP SPELRGRPDH AGQPDSDRPI GVLLMKSKAN
310 320 330 340 350
EEYGLRLGSQ IFIKQMTRTA LATKDGNLHE GDIILKINGT VTENMSLTDA
360 370 380 390 400
RKLIEKSRGK LQLVVLRDSK QTLINIPSLN DSDSEIEDIS EIESNRSFSP
410 420 430 440 450
EERRQQYSDY DYHSSNEKLK ERPNSREDMQ NRWSRMGATP TPFKSMGDIA
460 470 480 490 500
SVVGTENSKE PRYQEEPPAP QPKAAPRTFL RPSPEDEAIY GPNTKMVRFK
510 520 530 540 550
KGDSVGLRLA GGNDVGIFVA GIQEGTSAEQ EGLQEGDQIL KVNTQDFRGL
560 570 580 590 600
VREDAVLYLL EIPKGEMVTI LAQSRADVYR DILACGRGDS FFIRSHFECE
610 620 630 640 650
KETPQSLAFS RGEVFRVVDT LYDGKLGHWL AVRIGNELEK GLIPNKSRAE
660 670 680 690 700
QMASVQNAQR DNAGDRADFW RMRGQRSGMK KNLRKSREDL TAAVSVSTKF
710 720 730 740 750
PAYERVLLRE AGFKRPVVLF GPIADIALEK LANELPDLFQ TAKTEPKDAG
760 770 780 790 800
SEKSSGVVRL NTVRQIIEQD KHALLDVTPK AVDLLNYTQW FPIVIFFNPD
810 820 830 840 850
SRQGVKTMRQ RLNPTSNKSS RKLYDQANKL KKTCAHLFTA TINLNSANDS
860 870 880 890 900
WFGSLKDTIQ HQQGEAVWVS EGKMEGMDDD PEDRMSYLTA MGADYLSCDS
910 920 930 940 950
RLISDFEDTD GEGGAYTDNE LDEPAEEPLV SSITRSSEPV QHEESIRKPS
960 970 980 990 1000
PEPRAQMRRA ASRDQLRDSS PPPAFKPEPP KAKTQNREES FDISRSHDYK
1010 1020 1030 1040 1050
SNPSAVAGNE VSGASTRSCP PPIAAKPSFG RSILKPSTPV PSPESEEVGE
1060 1070 1080 1090 1100
GSEEQEGAPK SVLGKVKIFE KMDHKARLQR MQELQEAQNA RIEIAQKHPD
1110 1120 1130 1140 1150
IYAVPIKTHK PDPGLSQHTS SRPPEPQKGP SRLYQDPRGS YGSDAEEEEY
1160 1170
RQQLSEHSKR GYYSQPSRYR DTEL
Length:1,174
Mass (Da):132,086
Last modified:February 1, 1997 - v1
Checksum:i45AB836BBDDB1226
GO
Isoform 2 (identifier: Q95168-2)
Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27152 mRNA. Translation: AAC37332.1.
RefSeqiNP_001003204.1. NM_001003204.1. [Q95168-1]
UniGeneiCfa.1898.

Genome annotation databases

GeneIDi403854.
KEGGicfa:403854.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27152 mRNA. Translation: AAC37332.1.
RefSeqiNP_001003204.1. NM_001003204.1. [Q95168-1]
UniGeneiCfa.1898.

3D structure databases

ProteinModelPortaliQ95168.
SMRiQ95168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ95168. 2 interactors.
STRINGi9615.ENSCAFP00000002794.

PTM databases

iPTMnetiQ95168.

Proteomic databases

PaxDbiQ95168.
PRIDEiQ95168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403854.
KEGGicfa:403854.

Organism-specific databases

CTDi9414.

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ95168.
KOiK06098.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005419. ZO-2.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PRINTSiPR01597. ZONOCCLUDNS.
PR01599. ZONOCCLUDNS2.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZO2_CANLF
AccessioniPrimary (citable) accession number: Q95168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: May 10, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.