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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-390651 Dopamine receptors
R-BTA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
Synonyms:D1AR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:28207 DRD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 49Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 87Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini88 – 96ExtracellularSequence analysis9
Transmembranei97 – 119Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 163Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini164 – 192ExtracellularSequence analysisAdd BLAST29
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693711 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi347S-palmitoyl cysteineBy similarity1
Lipidationi351S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ95136
PRIDEiQ95136

Expressioni

Gene expression databases

BgeeiENSBTAG00000047719

Interactioni

Subunit structurei

Interacts with DRD1IP. Interacts with DNAJC14 via its C-terminus.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054107

Chemistry databases

BindingDBiQ95136

Structurei

3D structure databases

ProteinModelPortaliQ95136
SMRiQ95136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOVERGENiHBG106962
InParanoidiQ95136
KOiK04144
OMAiSLNRMYA
OrthoDBiEOG091G06VI
TreeFamiTF325181

Family and domain databases

InterProiView protein in InterPro
IPR001413 Dopamine_D1_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF10 PTHR43893:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00565 DOPAMINED1AR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q95136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLNTSTME GTGLVAERDF SFRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTG PSEGNATSLG KTINNCDSSL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP
260 270 280 290 300
MECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCMVPFCGS
310 320 330 340 350
GETKPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNVVYL IPHAVGSSEG
410 420 430 440
LKKEEAVGIA KPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,317
Last modified:May 30, 2006 - v2
Checksum:i00F13996BA7CB8EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF381032 mRNA Translation: AAL37945.1
BC134576 mRNA Translation: AAI34577.1
U73042 Genomic DNA Translation: AAB17281.1
RefSeqiNP_776467.1, NM_174042.2
XP_005211234.1, XM_005211177.3
XP_005211235.1, XM_005211178.3
UniGeneiBt.9029

Genome annotation databases

EnsembliENSBTAT00000062955; ENSBTAP00000054107; ENSBTAG00000047719
GeneIDi281125
KEGGibta:281125

Similar proteinsi

Entry informationi

Entry nameiDRD1_BOVIN
AccessioniPrimary (citable) accession number: Q95136
Secondary accession number(s): A4IFG9, Q8WND7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2006
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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