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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-390651. Dopamine receptors.
R-BTA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
Synonyms:D1AR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 49Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 87Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini88 – 96ExtracellularSequence analysis9
Transmembranei97 – 119Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 163Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini164 – 192ExtracellularSequence analysisAdd BLAST29
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693711 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Lipidationi347S-palmitoyl cysteineBy similarity1
Lipidationi351S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ95136.
PRIDEiQ95136.

Expressioni

Gene expression databases

BgeeiENSBTAG00000047719.

Interactioni

Subunit structurei

Interacts with DRD1IP. Interacts with DNAJC14 via its C-terminus.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054107.

Chemistry databases

BindingDBiQ95136.

Structurei

3D structure databases

ProteinModelPortaliQ95136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ95136.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
TreeFamiTF325181.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLNTSTME GTGLVAERDF SFRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTG PSEGNATSLG KTINNCDSSL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP
260 270 280 290 300
MECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCMVPFCGS
310 320 330 340 350
GETKPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNVVYL IPHAVGSSEG
410 420 430 440
LKKEEAVGIA KPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,317
Last modified:May 30, 2006 - v2
Checksum:i00F13996BA7CB8EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF381032 mRNA. Translation: AAL37945.1.
BC134576 mRNA. Translation: AAI34577.1.
U73042 Genomic DNA. Translation: AAB17281.1.
RefSeqiNP_776467.1. NM_174042.2.
XP_005211234.1. XM_005211177.3.
XP_005211235.1. XM_005211178.3.
UniGeneiBt.9029.

Genome annotation databases

EnsembliENSBTAT00000062955; ENSBTAP00000054107; ENSBTAG00000047719.
GeneIDi281125.
KEGGibta:281125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF381032 mRNA. Translation: AAL37945.1.
BC134576 mRNA. Translation: AAI34577.1.
U73042 Genomic DNA. Translation: AAB17281.1.
RefSeqiNP_776467.1. NM_174042.2.
XP_005211234.1. XM_005211177.3.
XP_005211235.1. XM_005211178.3.
UniGeneiBt.9029.

3D structure databases

ProteinModelPortaliQ95136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054107.

Chemistry databases

BindingDBiQ95136.
ChEMBLiCHEMBL2967.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ95136.
PRIDEiQ95136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000062955; ENSBTAP00000054107; ENSBTAG00000047719.
GeneIDi281125.
KEGGibta:281125.

Organism-specific databases

CTDi1812.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ95136.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiR-BTA-390651. Dopamine receptors.
R-BTA-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ95136.

Gene expression databases

BgeeiENSBTAG00000047719.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD1_BOVIN
AccessioniPrimary (citable) accession number: Q95136
Secondary accession number(s): A4IFG9, Q8WND7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.