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Protein

Excitatory amino acid transporter 3

Gene

SLC1A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transports L-glutamate, L- and D-aspartate and L-cystein. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 3
Alternative name(s):
Excitatory amino-acid carrier 1
Renal high affinity glutamate transporter EAAC1
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1
Gene namesi
Name:SLC1A1
Synonyms:EAAC1, EAAT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3820HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 20995ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 22920HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27320HelicalSequence analysisAdd
BLAST
Transmembranei290 – 30920HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33520HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38120HelicalSequence analysisAdd
BLAST
Transmembranei392 – 41120HelicalSequence analysisAdd
BLAST
Transmembranei420 – 43920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Excitatory amino acid transporter 3PRO_0000202064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei522 – 5221PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ95135.
PRIDEiQ95135.

Interactioni

Subunit structurei

Interacts with ARL6IP5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025456.

Structurei

3D structure databases

ProteinModelPortaliQ95135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ95135.
KOiK05612.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPARKGCD WKRFLRNNWL LLSTVVAVVL GIVIGVLVRE YSKLSNLEKF
60 70 80 90 100
YFSFPGEILM RMLKLVILPL IVSSMITGVA TLDSNVSGKI GLRAVVYYFC
110 120 130 140 150
TTLIAVILGI VLVVSIKPGV TQKVNEIDRT GNTPEVSTVD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTTREEVE LSEEPGTNST EATVTAIMTT AISKNKTKEY
210 220 230 240 250
KVVGMYSDGI NVLGLIVFCL VLGIVIGRKW EKGQILVDFF NALSDATMKI
260 270 280 290 300
VQIIMCYMPI GILFLIAGKI IEVEDWEIFR KLGLYMATVL SGLAIHSIVI
310 320 330 340 350
LPLIYFIIVR KNPFQFAMGM AQALLTALMI SSSSATLPVT FRCAEEKNRV
360 370 380 390 400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLS VGQIITISVT
410 420 430 440 450
ATAASIGAAG VPQPGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV
460 470 480 490 500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFTLEST ALDNEDSDTK
510 520
KSYVNGGFAV DKSDTISFTQ TSQF
Length:524
Mass (Da):57,297
Last modified:February 1, 1997 - v1
Checksum:i920256A70A302128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72534 mRNA. Translation: AAB16815.1.
PIRiS39017.
RefSeqiNP_777024.1. NM_174599.2.
UniGeneiBt.557.

Genome annotation databases

GeneIDi282353.
KEGGibta:282353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72534 mRNA. Translation: AAB16815.1.
PIRiS39017.
RefSeqiNP_777024.1. NM_174599.2.
UniGeneiBt.557.

3D structure databases

ProteinModelPortaliQ95135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025456.

Proteomic databases

PaxDbiQ95135.
PRIDEiQ95135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282353.
KEGGibta:282353.

Organism-specific databases

CTDi6505.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ95135.
KOiK05612.

Miscellaneous databases

NextBioi20806146.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Induction of high affinity glutamate transport activity by amino acid deprivation in renal epithelial cells does not involve an increase in the amount of transporter protein."
    Nicholson B., McGivan J.D.
    J. Biol. Chem. 271:12159-12164(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEAA3_BOVIN
AccessioniPrimary (citable) accession number: Q95135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.