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Protein

Excitatory amino acid transporter 3

Gene

SLC1A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transports L-glutamate, L- and D-aspartate and L-cystein. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 3
Alternative name(s):
Excitatory amino-acid carrier 1
Renal high affinity glutamate transporter EAAC1
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1
Gene namesi
Name:SLC1A1
Synonyms:EAAC1, EAAT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 38HelicalSequence analysisAdd BLAST20
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 209ExtracellularSequence analysisAdd BLAST95
Transmembranei210 – 229HelicalSequence analysisAdd BLAST20
Transmembranei254 – 273HelicalSequence analysisAdd BLAST20
Transmembranei290 – 309HelicalSequence analysisAdd BLAST20
Transmembranei316 – 335HelicalSequence analysisAdd BLAST20
Transmembranei362 – 381HelicalSequence analysisAdd BLAST20
Transmembranei392 – 411HelicalSequence analysisAdd BLAST20
Transmembranei420 – 439HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020641 – 524Excitatory amino acid transporter 3Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Modified residuei517PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ95135.
PRIDEiQ95135.

Interactioni

Subunit structurei

Interacts with ARL6IP5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025456.

Structurei

3D structure databases

ProteinModelPortaliQ95135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ95135.
KOiK05612.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPARKGCD WKRFLRNNWL LLSTVVAVVL GIVIGVLVRE YSKLSNLEKF
60 70 80 90 100
YFSFPGEILM RMLKLVILPL IVSSMITGVA TLDSNVSGKI GLRAVVYYFC
110 120 130 140 150
TTLIAVILGI VLVVSIKPGV TQKVNEIDRT GNTPEVSTVD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTTREEVE LSEEPGTNST EATVTAIMTT AISKNKTKEY
210 220 230 240 250
KVVGMYSDGI NVLGLIVFCL VLGIVIGRKW EKGQILVDFF NALSDATMKI
260 270 280 290 300
VQIIMCYMPI GILFLIAGKI IEVEDWEIFR KLGLYMATVL SGLAIHSIVI
310 320 330 340 350
LPLIYFIIVR KNPFQFAMGM AQALLTALMI SSSSATLPVT FRCAEEKNRV
360 370 380 390 400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLS VGQIITISVT
410 420 430 440 450
ATAASIGAAG VPQPGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV
460 470 480 490 500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFTLEST ALDNEDSDTK
510 520
KSYVNGGFAV DKSDTISFTQ TSQF
Length:524
Mass (Da):57,297
Last modified:February 1, 1997 - v1
Checksum:i920256A70A302128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72534 mRNA. Translation: AAB16815.1.
PIRiS39017.
RefSeqiNP_777024.1. NM_174599.2.
UniGeneiBt.557.

Genome annotation databases

GeneIDi282353.
KEGGibta:282353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72534 mRNA. Translation: AAB16815.1.
PIRiS39017.
RefSeqiNP_777024.1. NM_174599.2.
UniGeneiBt.557.

3D structure databases

ProteinModelPortaliQ95135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025456.

Proteomic databases

PaxDbiQ95135.
PRIDEiQ95135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282353.
KEGGibta:282353.

Organism-specific databases

CTDi6505.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ95135.
KOiK05612.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAA3_BOVIN
AccessioniPrimary (citable) accession number: Q95135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.