Reviewed, UniProtKB/Swiss-Prot Q95126 (AVR2B_BOVIN)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIB
      Short name=ACTR-IIB

Gene names

Name:

ACVR2B

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 512	494	Activin receptor type-2B		PRO_0000024403
Regions
	Topological domain	19 – 137	119	Extracellular Potential
	Transmembrane	138 – 158	21	Potential
	Topological domain	159 – 512	354	Cytoplasmic Potential
	Domain	190 – 480	291	Protein kinase
	Nucleotide binding	196 – 204	9	ATP By similarity
Sites
	Active site	321	1	Proton acceptor By similarity
	Binding site	217	1	ATP By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Disulfide bond	29 ↔ 59		By similarity
	Disulfide bond	49 ↔ 77		By similarity
	Disulfide bond	84 ↔ 103		By similarity
	Disulfide bond	90 ↔ 102		By similarity
	Disulfide bond	104 ↔ 109		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95126-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: D8E14D465B3EEF04	FASTA	512	57,569
	10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GERDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 130 140 150 160 170 180 GPEVTYEPPP TAPTLLTVLA YSLLPVGGLS LIALLAFWMY RHRKPPYGHA DIHEDPGPPP 190 200 210 220 230 240 PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 250 260 270 280 290 300 HENLLQFIAA EKRGSSLEAE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 310 320 330 340 350 360 LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 370 380 390 400 410 420 TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 430 440 450 460 470 480 HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 490 500 510 IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

References

[1]

"Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-homology 3 domain binding sites." Ethier J.-F., Lussier J.G., Silversides D.W. Endocrinology 138:2425-2434(1997) [PubMed: 9165032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Corpus luteum and Pituitary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57707 mRNA. Translation: AAC02647.1.
IPI	IPI00706908.
RefSeq	NP_776920.1.
UniGene	Bt.4990
3D structure databases
SMR	Q95126. Positions 24-117, 190-484.
ModBase	Search...
Protein-protein interaction databases
STRING	Q95126.
Genome annotation databases
Ensembl	ENSBTAT00000024095; ENSBTAP00000024095; ENSBTAG00000018105; Bos taurus. [Genome view]
GeneID	282131.
KEGG	bta:282131.
Organism-specific databases
CTD	282131.
Phylogenomic databases
HOVERGEN	Q95126.
InParanoid	Q95126.
Enzyme and pathway databases
BRENDA	2.7.10.2. 251. 2.7.11.30. 251.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2B_BOVIN

Accession

Primary (citable) accession number: Q95126

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 1997
Last modified:	January 19, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)