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Q95119 (TYRP2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-dopachrome tautomerase
Short name=DCT
Short name=DT
EC=5.3.3.12
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name=TRP-2
Short name=TRP2
Gene names
Name:DCT
Synonyms:TYRP2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in regulating eumelanin and phaeomelanin levels.

Catalytic activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Pathway

Pigment biosynthesis; melanin biosynthesis.

Subunit structure

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex By similarity.

Subcellular location

Melanosome membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 517494L-dopachrome tautomerase
PRO_0000186730

Regions

Topological domain24 – 469446Lumenal, melanosome Potential
Transmembrane470 – 49021Helical; Potential
Topological domain491 – 51727Cytoplasmic Potential

Sites

Metal binding1891Zinc A By similarity
Metal binding2111Zinc A By similarity
Metal binding2201Zinc A By similarity
Metal binding3691Zinc B By similarity
Metal binding3731Zinc B By similarity
Metal binding3961Zinc B By similarity

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential

Natural variations

Natural variant1521L → P. Ref.1 Ref.3
Natural variant1731R → Q. Ref.1 Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q95119 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: C71667D5D3C5D6C3

FASTA51758,787
        10         20         30         40         50         60 
MSPLGWGLLL GCLGCALPSG ARAQFPRVCM TVGSLQAKEC CPPLGADPAN VCGSREGRGQ 

        70         80         90        100        110        120 
CAEVQTDTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN FAGYNCGNCR FGWTGPKCDQ 

       130        140        150        160        170        180 
KKPLVVRRDV HSLTPQEREQ FLDALDLAKY TLHPDYVITT QHWLGLLGPN GTRPQIANCS 

       190        200        210        220        230        240 
IYDFFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERD LQRLTGNESF 

       250        260        270        280        290        300 
ALPYWNFATG RNECDVCTDQ LLGAARQDDP TLISQNSRFS SWEIVCDSLN DYNRRVTLCN 

       310        320        330        340        350        360 
GTYEGLLKRN QMGRNSEKLP TLKDIQNCLS LKKFDSPPFF QNSTLSFRNA LEGFGKADGT 

       370        380        390        400        410        420 
LDSQVMNFHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD AIFDEWMKRF NPPVDAWPRE 

       430        440        450        460        470        480 
LAPIGHNRMY NMVPFFPPVT NEELFLTADQ LGYSYAIDLP VEETPDWTTV LSVVTGMLVV 

       490        500        510 
LVVLFALLLF LQYRRLRKGY TPLVETQLSN KRYTEEA

« Hide

References

[1]"Transcriptional regulation of bovine TRP2 gene."
Guibert S., Leveziel H., Julien R., Oulmouden A.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-152 AND GLN-173.
Tissue: Skin.
[2]"Tyrosinase-related protein-2 (DCT; TYRP2) maps to bovine chromosome 12."
Hawkins G.A., Eggen A., Hayes H., Elduque C., Bishop M.D.
Mamm. Genome 7:474-475(1996) [PubMed: 8662245] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-191.
[3]"A SNP in TYRP2 is used for linkage mapping on cattle chromosome 12."
Schmutz S.M., Berryere T.G., Buchanan F.C.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 145-190, VARIANTS PRO-152 AND GLN-173.
Strain: Hereford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY278108 mRNA. Translation: AAP33051.1.
U46153 Genomic DNA. Translation: AAC48617.1.
AF152005 Genomic DNA. Translation: AAD41516.1.
IPIIPI00685772.
RefSeqNP_001012684.1. NM_001012666.1.
UniGeneBt.93330.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ95119.

Proteomic databases

PRIDEQ95119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID280761.
KEGGbta:280761.

Organism-specific databases

CTD1638.

Phylogenomic databases

eggNOGmaNOG11865.
GeneTreeENSGT00500000044790.
HOVERGENHBG003553.
InParanoidQ95119.
OrthoDBEOG4B5P4T.

Family and domain databases

InterProIPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
Gene3DG3DSA:1.10.1280.10. Di-copper_centre. 1 hit.
KOK01827.
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. Di-copper_centre. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRP2_BOVIN
AccessionPrimary (citable) accession number: Q95119
Secondary accession number(s): Q863I1, Q9XSZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 27, 2006
Last modified: November 16, 2011
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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