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Q95117

- SFRP3_BOVIN

UniProt

Q95117 - SFRP3_BOVIN

Protein

Secreted frizzled-related protein 3

Gene

FRZB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. Wnt-activated receptor activity Source: RefGenome
    3. Wnt-protein binding Source: AgBase

    GO - Biological processi

    1. brain development Source: RefGenome
    2. cochlea morphogenesis Source: RefGenome
    3. convergent extension involved in organogenesis Source: Ensembl
    4. epithelium development Source: RefGenome
    5. gonad development Source: RefGenome
    6. mammary gland involution Source: RefGenome
    7. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    8. negative regulation of cartilage development Source: RefGenome
    9. negative regulation of cell development Source: Ensembl
    10. negative regulation of cell growth Source: Ensembl
    11. negative regulation of cell proliferation Source: Ensembl
    12. negative regulation of hepatocyte differentiation Source: RefGenome
    13. negative regulation of Wnt signaling pathway Source: AgBase
    14. neural crest cell differentiation Source: Ensembl
    15. positive regulation of apoptotic process Source: Ensembl
    16. positive regulation of fat cell differentiation Source: Ensembl
    17. somite development Source: Ensembl
    18. vasculature development Source: RefGenome
    19. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 3
    Short name:
    sFRP-3
    Alternative name(s):
    Frizzled-related protein 1
    FrzB-1
    Gene namesi
    Name:FRZB
    Synonyms:FRZB1, SFRP3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 325293Secreted frizzled-related protein 3PRO_0000032545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 96By similarity
    Disulfide bondi43 ↔ 89By similarity
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi80 ↔ 119By similarity
    Disulfide bondi108 ↔ 147By similarity
    Disulfide bondi112 ↔ 136By similarity
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with MYOC.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95117.
    SMRiQ95117. Positions 33-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 150118FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 298121NTRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi301 – 31818Ser-richAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG304384.
    GeneTreeiENSGT00750000117492.
    HOGENOMiHOG000231879.
    HOVERGENiHBG070536.
    InParanoidiQ95117.
    OMAiEEYLIMG.
    OrthoDBiEOG79PJPC.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026556. SFRP3.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF76. PTHR11309:SF76. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95117-1 [UniParc]FASTAAdd to Basket

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    MVCGSRGGML LLPAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM    50
    TKMPNHLHHS TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF 100
    QHEPIKPCKS VCERARQGCE PILIKYRHSW PESLACEELP VYDRGVCISP 150
    EAIVTADGAD FPMDSSNGNC RGASSERCKC KPVRATQKTY FRNNYNYVIR 200
    AKVKEIKTKC HDVTAVVEVK EILKASLVNI PRETVNLYTS SGCLCPPLNV 250
    NEEYLIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLNT 300
    SDSSHSDSTQ SQKPGRNSNS RQARN 325
    Length:325
    Mass (Da):36,234
    Last modified:February 1, 1997 - v1
    Checksum:i39E337A9C6E98BB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24164 mRNA. Translation: AAC48662.1.
    BC112842 mRNA. Translation: AAI12843.1.
    RefSeqiNP_776484.1. NM_174059.2.
    XP_005202312.1. XM_005202255.1.
    XP_005202313.1. XM_005202256.1.
    UniGeneiBt.121.

    Genome annotation databases

    EnsembliENSBTAT00000014572; ENSBTAP00000014572; ENSBTAG00000010977.
    GeneIDi281170.
    KEGGibta:281170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24164 mRNA. Translation: AAC48662.1 .
    BC112842 mRNA. Translation: AAI12843.1 .
    RefSeqi NP_776484.1. NM_174059.2.
    XP_005202312.1. XM_005202255.1.
    XP_005202313.1. XM_005202256.1.
    UniGenei Bt.121.

    3D structure databases

    ProteinModelPortali Q95117.
    SMRi Q95117. Positions 33-157.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000014572 ; ENSBTAP00000014572 ; ENSBTAG00000010977 .
    GeneIDi 281170.
    KEGGi bta:281170.

    Organism-specific databases

    CTDi 2487.

    Phylogenomic databases

    eggNOGi NOG304384.
    GeneTreei ENSGT00750000117492.
    HOGENOMi HOG000231879.
    HOVERGENi HBG070536.
    InParanoidi Q95117.
    OMAi EEYLIMG.
    OrthoDBi EOG79PJPC.

    Miscellaneous databases

    NextBioi 20805230.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026556. SFRP3.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF76. PTHR11309:SF76. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis."
      Hoang B., Moos M. Jr., Vukicevic S., Luyten F.P.
      J. Biol. Chem. 271:26131-26137(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cartilage.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Kidney.
    3. "The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling."
      Lin K., Wang S., Julius M.A., Kitajewski J., Moos M. Jr., Luyten F.P.
      Proc. Natl. Acad. Sci. U.S.A. 94:11196-11200(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION OF THE FZ DOMAIN WITH WNT PROTEINS.

    Entry informationi

    Entry nameiSFRP3_BOVIN
    AccessioniPrimary (citable) accession number: Q95117
    Secondary accession number(s): Q2KHY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3