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Q95117

- SFRP3_BOVIN

UniProt

Q95117 - SFRP3_BOVIN

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Protein

Secreted frizzled-related protein 3

Gene

FRZB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

GO - Molecular functioni

  1. PDZ domain binding Source: RefGenome
  2. Wnt-activated receptor activity Source: RefGenome
  3. Wnt-protein binding Source: AgBase

GO - Biological processi

  1. brain development Source: RefGenome
  2. cochlea morphogenesis Source: RefGenome
  3. convergent extension involved in organogenesis Source: Ensembl
  4. epithelium development Source: RefGenome
  5. gonad development Source: RefGenome
  6. mammary gland involution Source: RefGenome
  7. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  8. negative regulation of cartilage development Source: RefGenome
  9. negative regulation of cell development Source: Ensembl
  10. negative regulation of cell growth Source: Ensembl
  11. negative regulation of cell proliferation Source: Ensembl
  12. negative regulation of hepatocyte differentiation Source: RefGenome
  13. negative regulation of Wnt signaling pathway Source: AgBase
  14. neural crest cell differentiation Source: Ensembl
  15. positive regulation of apoptotic process Source: Ensembl
  16. positive regulation of fat cell differentiation Source: Ensembl
  17. somite development Source: Ensembl
  18. vasculature development Source: RefGenome
  19. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 3
Short name:
sFRP-3
Alternative name(s):
Frizzled-related protein 1
FrzB-1
Gene namesi
Name:FRZB
Synonyms:FRZB1, SFRP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 325293Secreted frizzled-related protein 3PRO_0000032545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 96By similarity
Disulfide bondi43 ↔ 89By similarity
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi80 ↔ 119By similarity
Disulfide bondi108 ↔ 147By similarity
Disulfide bondi112 ↔ 136By similarity
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with MYOC.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95117.
SMRiQ95117. Positions 33-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 150118FZPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 298121NTRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi301 – 31818Ser-richAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG304384.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231879.
HOVERGENiHBG070536.
InParanoidiQ95117.
OMAiEEYLIMG.
OrthoDBiEOG79PJPC.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026556. SFRP3.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF76. PTHR11309:SF76. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95117-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCGSRGGML LLPAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM
60 70 80 90 100
TKMPNHLHHS TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF
110 120 130 140 150
QHEPIKPCKS VCERARQGCE PILIKYRHSW PESLACEELP VYDRGVCISP
160 170 180 190 200
EAIVTADGAD FPMDSSNGNC RGASSERCKC KPVRATQKTY FRNNYNYVIR
210 220 230 240 250
AKVKEIKTKC HDVTAVVEVK EILKASLVNI PRETVNLYTS SGCLCPPLNV
260 270 280 290 300
NEEYLIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLNT
310 320
SDSSHSDSTQ SQKPGRNSNS RQARN
Length:325
Mass (Da):36,234
Last modified:February 1, 1997 - v1
Checksum:i39E337A9C6E98BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24164 mRNA. Translation: AAC48662.1.
BC112842 mRNA. Translation: AAI12843.1.
RefSeqiNP_776484.1. NM_174059.2.
XP_005202312.1. XM_005202255.1.
XP_005202313.1. XM_005202256.1.
UniGeneiBt.121.

Genome annotation databases

EnsembliENSBTAT00000014572; ENSBTAP00000014572; ENSBTAG00000010977.
GeneIDi281170.
KEGGibta:281170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24164 mRNA. Translation: AAC48662.1 .
BC112842 mRNA. Translation: AAI12843.1 .
RefSeqi NP_776484.1. NM_174059.2.
XP_005202312.1. XM_005202255.1.
XP_005202313.1. XM_005202256.1.
UniGenei Bt.121.

3D structure databases

ProteinModelPortali Q95117.
SMRi Q95117. Positions 33-157.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I93.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000014572 ; ENSBTAP00000014572 ; ENSBTAG00000010977 .
GeneIDi 281170.
KEGGi bta:281170.

Organism-specific databases

CTDi 2487.

Phylogenomic databases

eggNOGi NOG304384.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000231879.
HOVERGENi HBG070536.
InParanoidi Q95117.
OMAi EEYLIMG.
OrthoDBi EOG79PJPC.

Miscellaneous databases

NextBioi 20805230.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026556. SFRP3.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF76. PTHR11309:SF76. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis."
    Hoang B., Moos M. Jr., Vukicevic S., Luyten F.P.
    J. Biol. Chem. 271:26131-26137(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Kidney.
  3. "The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling."
    Lin K., Wang S., Julius M.A., Kitajewski J., Moos M. Jr., Luyten F.P.
    Proc. Natl. Acad. Sci. U.S.A. 94:11196-11200(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION OF THE FZ DOMAIN WITH WNT PROTEINS.

Entry informationi

Entry nameiSFRP3_BOVIN
AccessioniPrimary (citable) accession number: Q95117
Secondary accession number(s): Q2KHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3