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Q95116

- TSP2_BOVIN

UniProt

Q95116 - TSP2_BOVIN

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Protein

Thrombospondin-2

Gene

THBS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties By similarity.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. negative regulation of angiogenesis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-2
Alternative name(s):
Corticotropin-induced secreted protein
Short name:
CISP
Gene namesi
Name:THBS2
Synonyms:TSP-2, TSP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: InterPro
  2. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 11701152Thrombospondin-2PRO_0000035845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 – 266InterchainCurated
Disulfide bondi270 – 270InterchainCurated
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi391 ↔ 423By similarity
Disulfide bondi395 ↔ 428By similarity
Disulfide bondi406 ↔ 413By similarity
Disulfide bondi447 ↔ 484By similarity
Disulfide bondi451 ↔ 489By similarity
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi462 ↔ 474By similarity
Disulfide bondi504 ↔ 541By similarity
Disulfide bondi508 ↔ 546By similarity
Disulfide bondi519 ↔ 531By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 572By similarity
Disulfide bondi575 ↔ 586By similarity
Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi592 ↔ 608By similarity
Disulfide bondi599 ↔ 617By similarity
Disulfide bondi620 ↔ 644By similarity
Disulfide bondi650 ↔ 663By similarity
Disulfide bondi657 ↔ 676By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi705 ↔ 713By similarity
Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi718 ↔ 738By similarity
Disulfide bondi754 ↔ 774By similarity
Disulfide bondi777 ↔ 797By similarity
Disulfide bondi813 ↔ 833By similarity
Disulfide bondi836 ↔ 856By similarity
Disulfide bondi874 ↔ 894By similarity
Disulfide bondi910 ↔ 930By similarity
Glycosylationi936 – 9361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi946 ↔ 1167By similarity
Glycosylationi1067 – 10671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ95116.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95116.
SMRiQ95116. Positions 549-1169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 215197Laminin G-likeAdd
BLAST
Domaini318 – 37558VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini379 – 42951TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini435 – 49056TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini492 – 54756TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini547 – 58741EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini646 – 69045EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Repeati691 – 72636TSP type-3 1Add
BLAST
Repeati727 – 76236TSP type-3 2Add
BLAST
Repeati763 – 78523TSP type-3 3Add
BLAST
Repeati786 – 82136TSP type-3 4Add
BLAST
Repeati822 – 84423TSP type-3 5Add
BLAST
Repeati845 – 88238TSP type-3 6Add
BLAST
Repeati883 – 91836TSP type-3 7Add
BLAST
Repeati919 – 95436TSP type-3 8Add
BLAST
Domaini958 – 1170213TSP C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 232214Heparin-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi926 – 9283Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
InParanoidiQ95116.
KOiK04659.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWPLLLLAL WAWPSAQAGD QDEDTAFDLF SISNINRKTI GAKQFRGPDP
60 70 80 90 100
SVPAYRFVRF DYIPPVSAEH LGRITEAMRR KEGFFLTASM KQDRRSRGTL
110 120 130 140 150
LALEGPGATH RQFEIVSNGP ADTLDLTYWV DGTQHVISLE DVGLADSQWK
160 170 180 190 200
NVTVQVTGET YSLYVGCDLM DSFALDEPFY EHLQTERSRM YVTKGAARES
210 220 230 240 250
HFRGLLQNVY LVFENSVEDL LSKKGCQQSQ GAETNAISEN TETLHLSPMV
260 270 280 290 300
TMEHVGPSAE KSPEVCEHSC EELGSMIREL SGLHVIVNQL HENLRKVSND
310 320 330 340 350
NQFLWELIGG PPKTRNVSAC WQDGRFFAEN ETWVVDSCTK CTCKKFKTVC
360 370 380 390 400
HQISCPPATC ADPWFVEGEC CPSCVHDGEE GWSPWAEWTE CSATCGSGTQ
410 420 430 440 450
QRGRSCDVTS NTCLGPSIQT RACSLGRCDH RIRQDGGWSH WSPWSSCSVT
460 470 480 490 500
CGVGNVTRIR LCNSPVPQMG GRSCKGSGRE TKACQGPPCP VDGRWSPWSP
510 520 530 540 550
WSACTVTCAG GIRERTRVCN SPEPQHGGKD CVGGAKEQQM CNRKSCPIDG
560 570 580 590 600
CLSNPCFPGA ECSSFPDGSW SCGSCPGGFL GNGTHCEDLD ECAVVTDVCF
610 620 630 640 650
ATSKAHRCVN TNPGYHCLPC PPRYKGNQPF GVGLEAARTE KQVCEPENPC
660 670 680 690 700
KDKTHSCHRH AECIYLGHFS DPMYKCECQT GYAGDGLICG EDSDLDGWPN
710 720 730 740 750
KNLVCATNAT YHCVKDNCPL LPNSGQEDFD KDGIGDACDD DDDNDGVSDE
760 770 780 790 800
KDNCQLLFNP RQFDYDKDEV GDRCDNCPYV HNPAQIDTDN NGEGDACSVD
810 820 830 840 850
IDGDDVFNER DNCPYVYNTD QRDTDGDGVG DHCDNCPLVH NPDQTDVDND
860 870 880 890 900
LVGDQCDNNE DIDEDGHQNN QDNCPHIPNA NQADHDRDGQ GDACDSDDDN
910 920 930 940 950
DGIPDDRDNC RLVANPDQED SDGDRRGDAC KDDFDNDSIP DIDDVCPENN
960 970 980 990 1000
AISETDFRNF QMVHLDPKGT TQIDPNWVIR HQGKELVQTA NSDPGIAVGF
1010 1020 1030 1040 1050
DEFGSVDFSG TFYVNTDRDD DYAGFVFGYQ SSSRFYVVMW KQVTQTYWED
1060 1070 1080 1090 1100
QPTRAYGYSG VSLKVVNSTT GTGEHLRNAL WHTGNTEGQV RTLWHDPKNI
1110 1120 1130 1140 1150
GWKDYTAYRW HLTHRPKTGY IRVLVHEGKQ VMADSGPIYD QTYAGGRLGL
1160 1170
FVFSQEMVYF SDLKYECRDV
Length:1,170
Mass (Da):129,863
Last modified:July 15, 1999 - v2
Checksum:i9CF1FBF55B89A051
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti535 – 5351A → V in CAA60952. 1 PublicationCurated
Sequence conflicti748 – 7481S → T in CAA60952. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96540 mRNA. Translation: CAA65385.1.
X87620 mRNA. Translation: CAA60952.1.
RefSeqiNP_789861.1. NM_176872.1.
UniGeneiBt.5522.

Genome annotation databases

GeneIDi338092.
KEGGibta:338092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96540 mRNA. Translation: CAA65385.1 .
X87620 mRNA. Translation: CAA60952.1 .
RefSeqi NP_789861.1. NM_176872.1.
UniGenei Bt.5522.

3D structure databases

ProteinModelPortali Q95116.
SMRi Q95116. Positions 549-1169.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q95116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 338092.
KEGGi bta:338092.

Organism-specific databases

CTDi 7058.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000007542.
HOVERGENi HBG018006.
InParanoidi Q95116.
KOi K04659.

Miscellaneous databases

NextBioi 20812537.

Family and domain databases

Gene3Di 2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR001791. Laminin_G.
IPR015455. Thrombospondin-2.
IPR000884. Thrombospondin_1_rpt.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_C.
[Graphical view ]
PANTHERi PTHR10199:SF10. PTHR10199:SF10. 1 hit.
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Danik M., Chinn A., Lafeuillade M., Keramidas M., Aguesse-Germon S., Penhoat A., Chen H., Mosher D., Chambaz E.M., Feige J.J.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells."
    Lafeuillade B., Pellerin S., Keramidas M., Danik M., Chambaz E.M., Feige J.J.
    J. Cell. Physiol. 167:164-172(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-522.
  3. "Cloning and sequencing of bovine thrombospondin stimulatory effect of TGF-beta."
    Zafar R.S., Moll Y.D., Womack J.F., Walz D.A.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-831.
    Tissue: Aortic endothelium.

Entry informationi

Entry nameiTSP2_BOVIN
AccessioniPrimary (citable) accession number: Q95116
Secondary accession number(s): Q28180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3