Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q95116

- TSP2_BOVIN

UniProt

Q95116 - TSP2_BOVIN

Protein

Thrombospondin-2

Gene

THBS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. negative regulation of angiogenesis Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-2
    Alternative name(s):
    Corticotropin-induced secreted protein
    Short name:
    CISP
    Gene namesi
    Name:THBS2
    Synonyms:TSP-2, TSP2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: InterPro
    2. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 11701152Thrombospondin-2PRO_0000035845Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi266 – 266InterchainCurated
    Disulfide bondi270 – 270InterchainCurated
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi391 ↔ 423By similarity
    Disulfide bondi395 ↔ 428By similarity
    Disulfide bondi406 ↔ 413By similarity
    Disulfide bondi447 ↔ 484By similarity
    Disulfide bondi451 ↔ 489By similarity
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi462 ↔ 474By similarity
    Disulfide bondi504 ↔ 541By similarity
    Disulfide bondi508 ↔ 546By similarity
    Disulfide bondi519 ↔ 531By similarity
    Disulfide bondi551 ↔ 562By similarity
    Disulfide bondi556 ↔ 572By similarity
    Disulfide bondi575 ↔ 586By similarity
    Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi592 ↔ 608By similarity
    Disulfide bondi599 ↔ 617By similarity
    Disulfide bondi620 ↔ 644By similarity
    Disulfide bondi650 ↔ 663By similarity
    Disulfide bondi657 ↔ 676By similarity
    Disulfide bondi678 ↔ 689By similarity
    Disulfide bondi705 ↔ 713By similarity
    Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi718 ↔ 738By similarity
    Disulfide bondi754 ↔ 774By similarity
    Disulfide bondi777 ↔ 797By similarity
    Disulfide bondi813 ↔ 833By similarity
    Disulfide bondi836 ↔ 856By similarity
    Disulfide bondi874 ↔ 894By similarity
    Disulfide bondi910 ↔ 930By similarity
    Glycosylationi936 – 9361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi946 ↔ 1167By similarity
    Glycosylationi1067 – 10671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ95116.

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ95116.
    SMRiQ95116. Positions 549-1169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 215197Laminin G-likeAdd
    BLAST
    Domaini318 – 37558VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini379 – 42951TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini435 – 49056TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini492 – 54756TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini547 – 58741EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini646 – 69045EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati691 – 72636TSP type-3 1Add
    BLAST
    Repeati727 – 76236TSP type-3 2Add
    BLAST
    Repeati763 – 78523TSP type-3 3Add
    BLAST
    Repeati786 – 82136TSP type-3 4Add
    BLAST
    Repeati822 – 84423TSP type-3 5Add
    BLAST
    Repeati845 – 88238TSP type-3 6Add
    BLAST
    Repeati883 – 91836TSP type-3 7Add
    BLAST
    Repeati919 – 95436TSP type-3 8Add
    BLAST
    Domaini958 – 1170213TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 232214Heparin-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi926 – 9283Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 3 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000007542.
    HOVERGENiHBG018006.
    InParanoidiQ95116.
    KOiK04659.

    Family and domain databases

    Gene3Di2.60.120.200. 3 hits.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR001791. Laminin_G.
    IPR015455. Thrombospondin-2.
    IPR000884. Thrombospondin_1_rpt.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PANTHERiPTHR10199:SF10. PTHR10199:SF10. 1 hit.
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF00090. TSP_1. 3 hits.
    PF02412. TSP_3. 7 hits.
    PF05735. TSP_C. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 3 hits.
    SM00209. TSP1. 3 hits.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82895. SSF82895. 3 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS50092. TSP1. 3 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95116-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWPLLLLAL WAWPSAQAGD QDEDTAFDLF SISNINRKTI GAKQFRGPDP     50
    SVPAYRFVRF DYIPPVSAEH LGRITEAMRR KEGFFLTASM KQDRRSRGTL 100
    LALEGPGATH RQFEIVSNGP ADTLDLTYWV DGTQHVISLE DVGLADSQWK 150
    NVTVQVTGET YSLYVGCDLM DSFALDEPFY EHLQTERSRM YVTKGAARES 200
    HFRGLLQNVY LVFENSVEDL LSKKGCQQSQ GAETNAISEN TETLHLSPMV 250
    TMEHVGPSAE KSPEVCEHSC EELGSMIREL SGLHVIVNQL HENLRKVSND 300
    NQFLWELIGG PPKTRNVSAC WQDGRFFAEN ETWVVDSCTK CTCKKFKTVC 350
    HQISCPPATC ADPWFVEGEC CPSCVHDGEE GWSPWAEWTE CSATCGSGTQ 400
    QRGRSCDVTS NTCLGPSIQT RACSLGRCDH RIRQDGGWSH WSPWSSCSVT 450
    CGVGNVTRIR LCNSPVPQMG GRSCKGSGRE TKACQGPPCP VDGRWSPWSP 500
    WSACTVTCAG GIRERTRVCN SPEPQHGGKD CVGGAKEQQM CNRKSCPIDG 550
    CLSNPCFPGA ECSSFPDGSW SCGSCPGGFL GNGTHCEDLD ECAVVTDVCF 600
    ATSKAHRCVN TNPGYHCLPC PPRYKGNQPF GVGLEAARTE KQVCEPENPC 650
    KDKTHSCHRH AECIYLGHFS DPMYKCECQT GYAGDGLICG EDSDLDGWPN 700
    KNLVCATNAT YHCVKDNCPL LPNSGQEDFD KDGIGDACDD DDDNDGVSDE 750
    KDNCQLLFNP RQFDYDKDEV GDRCDNCPYV HNPAQIDTDN NGEGDACSVD 800
    IDGDDVFNER DNCPYVYNTD QRDTDGDGVG DHCDNCPLVH NPDQTDVDND 850
    LVGDQCDNNE DIDEDGHQNN QDNCPHIPNA NQADHDRDGQ GDACDSDDDN 900
    DGIPDDRDNC RLVANPDQED SDGDRRGDAC KDDFDNDSIP DIDDVCPENN 950
    AISETDFRNF QMVHLDPKGT TQIDPNWVIR HQGKELVQTA NSDPGIAVGF 1000
    DEFGSVDFSG TFYVNTDRDD DYAGFVFGYQ SSSRFYVVMW KQVTQTYWED 1050
    QPTRAYGYSG VSLKVVNSTT GTGEHLRNAL WHTGNTEGQV RTLWHDPKNI 1100
    GWKDYTAYRW HLTHRPKTGY IRVLVHEGKQ VMADSGPIYD QTYAGGRLGL 1150
    FVFSQEMVYF SDLKYECRDV 1170
    Length:1,170
    Mass (Da):129,863
    Last modified:July 15, 1999 - v2
    Checksum:i9CF1FBF55B89A051
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti535 – 5351A → V in CAA60952. 1 PublicationCurated
    Sequence conflicti748 – 7481S → T in CAA60952. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96540 mRNA. Translation: CAA65385.1.
    X87620 mRNA. Translation: CAA60952.1.
    RefSeqiNP_789861.1. NM_176872.1.
    UniGeneiBt.5522.

    Genome annotation databases

    GeneIDi338092.
    KEGGibta:338092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96540 mRNA. Translation: CAA65385.1 .
    X87620 mRNA. Translation: CAA60952.1 .
    RefSeqi NP_789861.1. NM_176872.1.
    UniGenei Bt.5522.

    3D structure databases

    ProteinModelPortali Q95116.
    SMRi Q95116. Positions 549-1169.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q95116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 338092.
    KEGGi bta:338092.

    Organism-specific databases

    CTDi 7058.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000007542.
    HOVERGENi HBG018006.
    InParanoidi Q95116.
    KOi K04659.

    Miscellaneous databases

    NextBioi 20812537.

    Family and domain databases

    Gene3Di 2.60.120.200. 3 hits.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR001791. Laminin_G.
    IPR015455. Thrombospondin-2.
    IPR000884. Thrombospondin_1_rpt.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    PANTHERi PTHR10199:SF10. PTHR10199:SF10. 1 hit.
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF00090. TSP_1. 3 hits.
    PF02412. TSP_3. 7 hits.
    PF05735. TSP_C. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 3 hits.
    SM00209. TSP1. 3 hits.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    SSF82895. SSF82895. 3 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS50092. TSP1. 3 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Danik M., Chinn A., Lafeuillade M., Keramidas M., Aguesse-Germon S., Penhoat A., Chen H., Mosher D., Chambaz E.M., Feige J.J.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells."
      Lafeuillade B., Pellerin S., Keramidas M., Danik M., Chambaz E.M., Feige J.J.
      J. Cell. Physiol. 167:164-172(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-522.
    3. "Cloning and sequencing of bovine thrombospondin stimulatory effect of TGF-beta."
      Zafar R.S., Moll Y.D., Womack J.F., Walz D.A.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-831.
      Tissue: Aortic endothelium.

    Entry informationi

    Entry nameiTSP2_BOVIN
    AccessioniPrimary (citable) accession number: Q95116
    Secondary accession number(s): Q28180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3