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Protein

Neural Wiskott-Aldrich syndrome protein

Gene

WASL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization (By similarity). Regulates actin polymerization by stimulating the actin-nucleating activity of the actin-related protein 2/3 (Arp2/3) complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-203641 NOSTRIN mediated eNOS trafficking
R-BTA-373753 Nephrin family interactions
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-5663213 RHO GTPases Activate WASPs and WAVEs
R-BTA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Neural Wiskott-Aldrich syndrome protein
Short name:
N-WASP
Gene namesi
Name:WASL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001889992 – 505Neural Wiskott-Aldrich syndrome proteinAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei242Phosphoserine; by TNK2By similarity1
Modified residuei256Phosphotyrosine; by FAK1 and TNK2By similarity1
Modified residuei307Omega-N-methylarginineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ95107
PeptideAtlasiQ95107
PRIDEiQ95107

PTM databases

iPTMnetiQ95107

Expressioni

Gene expression databases

BgeeiENSBTAG00000004643

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11. Interacts with NOSTRIN. Binds to TNK2. Interacts with PTK2/FAK1. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with SNX33 (By similarity). Interacts with SNX9.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

Protein-protein interaction databases

CORUMiQ95107
ELMiQ95107
IntActiQ95107, 5 interactors
STRINGi9913.ENSBTAP00000006094

Structurei

3D structure databases

ProteinModelPortaliQ95107
SMRiQ95107
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 141WH1PROSITE-ProRule annotationAdd BLAST108
Domaini203 – 216CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini405 – 422WH2 1PROSITE-ProRule annotationAdd BLAST18
Domaini433 – 450WH2 2PROSITE-ProRule annotationAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 392Pro-richAdd BLAST116
Compositional biasi486 – 505Asp-richAdd BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3671 Eukaryota
ENOG4111J0D LUCA
GeneTreeiENSGT00730000110895
HOGENOMiHOG000143378
HOVERGENiHBG000222
InParanoidiQ95107
KOiK05747
OMAiKCQTLNT
OrthoDBiEOG091G0VCD
TreeFamiTF316736

Family and domain databases

CDDicd00132 CRIB, 1 hit
cd01205 EVH1_WASP-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.90.810.10, 2 hits
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR030214 N-WASP
IPR011993 PH-like_dom_sf
IPR011026 WASP_C
IPR033927 WASPfam_EVH1
IPR000697 WH1/EVH1_dom
IPR003124 WH2_dom
PANTHERiPTHR23202:SF39 PTHR23202:SF39, 1 hit
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00568 WH1, 1 hit
PF02205 WH2, 2 hits
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00461 WH1, 1 hit
SM00246 WH2, 2 hits
SUPFAMiSSF47912 SSF47912, 2 hits
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS50229 WH1, 1 hit
PS51082 WH2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA
60 70 80 90 100
ADRNCMWSKK CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY
110 120 130 140 150
NSPRGYFHTF AGDTCQVALN FANEEEAKKF RKAVTDLLGR RQRKSEKRRD
160 170 180 190 200
PPNGPNLPMA TVDIKNPEIT TNRFYGPQIN NISHTKEKKK GKAKKKRLTK
210 220 230 240 250
ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG ISEAQLKDRE
260 270 280 290 300
TSKVIYDFIE KTGGVEAVKN ELRRQAPPPP PPSRGGPPPP PPPPHSSGPP
310 320 330 340 350
PPPARGRGAP PPPPSRAPTA APPPPPPSRP GVGAPPPPPN RMYPPPLPAL
360 370 380 390 400
PSSAPSGPPP PPPPLSVSGS VAPPPPPPPP PPPGPPPPPG LPSDGDHQVP
410 420 430 440 450
TPAGSKAALL DQIREGAQLK KVEQNSRPVS CSGRDALLDQ IRQGIQLKSV
460 470 480 490 500
TDAPESTPPA PAPTSGIVGA LMEVMQKRSK AIHSSDEDED EDDDEDFEDD

DEWED
Length:505
Mass (Da):54,672
Last modified:February 1, 1997 - v1
Checksum:i54B83B48F1CDB3B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67066 mRNA Translation: BAA11082.1
PIRiS72273
RefSeqiNP_776644.1, NM_174219.2
UniGeneiBt.359

Genome annotation databases

EnsembliENSBTAT00000006094; ENSBTAP00000006094; ENSBTAG00000004643
GeneIDi281577
KEGGibta:281577

Similar proteinsi

Entry informationi

Entry nameiWASL_BOVIN
AccessioniPrimary (citable) accession number: Q95107
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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