ID   PDYN_BOVIN              Reviewed;         258 AA.
AC   Q95104;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   24-JAN-2024, entry version 103.
DE   RecName: Full=Proenkephalin-B;
DE   AltName: Full=Beta-neoendorphin-dynorphin;
DE   AltName: Full=Preprodynorphin;
DE   Contains:
DE     RecName: Full=Alpha-neoendorphin;
DE   Contains:
DE     RecName: Full=Beta-neoendorphin;
DE   Contains:
DE     RecName: Full=Big dynorphin;
DE              Short=Big Dyn;
DE   Contains:
DE     RecName: Full=Dynorphin A(1-17);
DE              Short=Dyn-A17;
DE              Short=Dynorphin A;
DE   Contains:
DE     RecName: Full=Dynorphin A(1-13);
DE   Contains:
DE     RecName: Full=Dynorphin A(1-8);
DE   Contains:
DE     RecName: Full=Leu-enkephalin;
DE   Contains:
DE     RecName: Full=Rimorphin;
DE     AltName: Full=Dynorphin B;
DE              Short=Dyn-B;
DE     AltName: Full=Dynorphin B(1-13);
DE   Contains:
DE     RecName: Full=Leumorphin;
DE     AltName: Full=Dynorphin B-29;
DE   Flags: Precursor;
GN   Name=PDYN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9074507; DOI=10.1016/s0378-1119(96)00721-4;
RA   Jiang H., Weesner G.D., Malven P.V.;
RT   "cDNA sequence and expression of bovine prodynorphin.";
RL   Gene 186:279-283(1997).
CC   -!- FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate
CC       drugs. They play a role in a number of physiologic functions, including
CC       pain perception and responses to stress (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Dynorphin peptides differentially regulate the kappa opioid
CC       receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700
CC       times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Leumorphin has a typical opioid activity and may have anti-
CC       apoptotic effect. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC       involved in disulfide bonding and/or processing.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000305}.
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DR   EMBL; U58500; AAC48706.1; -; mRNA.
DR   PIR; JC6318; JC6318.
DR   RefSeq; NP_776564.1; NM_174139.2.
DR   AlphaFoldDB; Q95104; -.
DR   STRING; 9913.ENSBTAP00000068675; -.
DR   PaxDb; 9913-ENSBTAP00000055430; -.
DR   GeneID; 281385; -.
DR   KEGG; bta:281385; -.
DR   CTD; 5173; -.
DR   eggNOG; ENOG502RXT4; Eukaryota.
DR   InParanoid; Q95104; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0007600; P:sensory perception; IBA:GO_Central.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000750; Proenkphlin_B.
DR   PANTHER; PTHR11438; PROENKEPHALIN; 1.
DR   PANTHER; PTHR11438:SF4; PROENKEPHALIN-B; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01030; PENKBPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Endorphin;
KW   Neuropeptide; Neurotransmitter; Opioid peptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..172
FT                   /id="PRO_0000008162"
FT   PEPTIDE         175..184
FT                   /note="Alpha-neoendorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306335"
FT   PEPTIDE         175..183
FT                   /note="Beta-neoendorphin"
FT                   /id="PRO_0000008163"
FT   PEPTIDE         175..179
FT                   /note="Leu-enkephalin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306336"
FT   PROPEP          186..208
FT                   /id="PRO_0000008164"
FT   PEPTIDE         211..242
FT                   /note="Big dynorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306337"
FT   PEPTIDE         211..227
FT                   /note="Dynorphin A(1-17)"
FT                   /id="PRO_0000008165"
FT   PEPTIDE         211..223
FT                   /note="Dynorphin A(1-13)"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306338"
FT   PEPTIDE         211..218
FT                   /note="Dynorphin A(1-8)"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306339"
FT   PEPTIDE         211..215
FT                   /note="Leu-enkephalin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000306340"
FT   PEPTIDE         230..258
FT                   /note="Leumorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008166"
FT   PEPTIDE         230..242
FT                   /note="Rimorphin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008167"
FT   PEPTIDE         230..234
FT                   /note="Leu-enkephalin"
FT                   /id="PRO_0000008168"
SQ   SEQUENCE   258 AA;  28790 MW;  AA51C34022F18046 CRC64;
     MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ AALQPAQEWE
     RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR PYLKELEKNR FLLSTPAEKN
     ALSSSLVEKL RGLSGRLGED AESELMGDAQ LNDGALEAEA RDSNEEEPKE QVKRYGGFLR
     KYPKRSSEVT GKEAGEGEGG EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV
     VTRSQEDPSA YYEELFDV
//