Q95104 (PDYN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proenkephalin-B

Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin

Cleaved into the following 9 chains:

1. Alpha-neoendorphin
2. Beta-neoendorphin
3. Big dynorphin
   Short name=Big Dyn
4. Dynorphin A(1-17)
   Short name=Dyn-A17
   Short name=Dynorphin A
5. Dynorphin A(1-13)
6. Dynorphin A(1-8)
7. Leu-enkephalin
8. Rimorphin
   Alternative name(s):
   Dynorphin B
   Short name=Dyn-B
   Dynorphin B(1-13)
9. Leumorphin
   Alternative name(s):
   Dynorphin B-29

Gene names

Name:

PDYN

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity. Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity.
Subcellular location	Secreted.
Post-translational modification	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence similarities	Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Endorphin Neuropeptide Neurotransmitter Opioid peptide
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 172	152			PRO_0000008162
	Peptide	175 – 184	10	Alpha-neoendorphin By similarity		PRO_0000306335
	Peptide	175 – 183	9	Beta-neoendorphin		PRO_0000008163
	Peptide	175 – 179	5	Leu-enkephalin By similarity		PRO_0000306336
	Propeptide	186 – 208	23			PRO_0000008164
	Peptide	211 – 242	32	Big dynorphin By similarity		PRO_0000306337
	Peptide	211 – 227	17	Dynorphin A(1-17)		PRO_0000008165
	Peptide	211 – 223	13	Dynorphin A(1-13) By similarity		PRO_0000306338
	Peptide	211 – 218	8	Dynorphin A(1-8) By similarity		PRO_0000306339
	Peptide	211 – 215	5	Leu-enkephalin By similarity		PRO_0000306340
	Peptide	230 – 258	29	Leumorphin By similarity		PRO_0000008166
	Peptide	230 – 242	13	Rimorphin By similarity		PRO_0000008167
	Peptide	230 – 234	5	Leu-enkephalin		PRO_0000008168

Sequences

	Sequence		Length	Mass (Da)
	Q95104 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: AA51C34022F18046	FASTA	258	28,790
	10 20 30 40 50 60 MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ AALQPAQEWE 70 80 90 100 110 120 RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR PYLKELEKNR FLLSTPAEKN 130 140 150 160 170 180 ALSSSLVEKL RGLSGRLGED AESELMGDAQ LNDGALEAEA RDSNEEEPKE QVKRYGGFLR 190 200 210 220 230 240 KYPKRSSEVT GKEAGEGEGG EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV 250 VTRSQEDPSA YYEELFDV

References

[1]	"cDNA sequence and expression of bovine prodynorphin." Jiang H., Weesner G.D., Malven P.V. Gene 186:279-283(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U58500 mRNA. Translation: AAC48706.1.
IPI	IPI00687344.
PIR	JC6318.
RefSeq	NP_776564.1. NM_174139.2.
UniGene	Bt.124.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	281385.
KEGG	bta:281385.
Organism-specific databases
CTD	5173.
Phylogenomic databases
eggNOG	NOG46156.
HOGENOM	HOG000013003.
HOVERGEN	HBG000063.
InParanoid	Q95104.
KO	K15840.
OrthoDB	EOG4QFWFK.
Family and domain databases
InterPro	IPR006024. Opioid_neupept. IPR000750. Proenkphlin_B. [Graphical view]
PANTHER	PTHR11438. PTHR11438. 1 hit. PTHR11438:SF4. PTHR11438:SF4. 1 hit.
Pfam	PF01160. Opiods_neuropep. 1 hit. [Graphical view]
PRINTS	PR01028. OPIOIDPRCRSR. PR01030. PENKBPRCRSR.
PROSITE	PS01252. OPIOIDS_PRECURSOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805385.

Entry information

Entry name

PDYN_BOVIN

Accession

Primary (citable) accession number: Q95104

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program