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Protein

Proenkephalin-B

Gene

PDYN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 172152PRO_0000008162Add
BLAST
Peptidei175 – 18410Alpha-neoendorphinBy similarityPRO_0000306335
Peptidei175 – 1839Beta-neoendorphinPRO_0000008163
Peptidei175 – 1795Leu-enkephalinBy similarityPRO_0000306336
Propeptidei186 – 20823PRO_0000008164Add
BLAST
Peptidei211 – 24232Big dynorphinBy similarityPRO_0000306337Add
BLAST
Peptidei211 – 22717Dynorphin A(1-17)PRO_0000008165Add
BLAST
Peptidei211 – 22313Dynorphin A(1-13)By similarityPRO_0000306338Add
BLAST
Peptidei211 – 2188Dynorphin A(1-8)By similarityPRO_0000306339
Peptidei211 – 2155Leu-enkephalinBy similarityPRO_0000306340
Peptidei230 – 25829LeumorphinBy similarityPRO_0000008166Add
BLAST
Peptidei230 – 24213RimorphinBy similarityPRO_0000008167Add
BLAST
Peptidei230 – 2345Leu-enkephalinPRO_0000008168

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiQ95104.
KOiK15840.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ
60 70 80 90 100
AALQPAQEWE RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR
110 120 130 140 150
PYLKELEKNR FLLSTPAEKN ALSSSLVEKL RGLSGRLGED AESELMGDAQ
160 170 180 190 200
LNDGALEAEA RDSNEEEPKE QVKRYGGFLR KYPKRSSEVT GKEAGEGEGG
210 220 230 240 250
EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV VTRSQEDPSA

YYEELFDV
Length:258
Mass (Da):28,790
Last modified:February 1, 1997 - v1
Checksum:iAA51C34022F18046
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58500 mRNA. Translation: AAC48706.1.
PIRiJC6318.
RefSeqiNP_776564.1. NM_174139.2.
UniGeneiBt.124.

Genome annotation databases

GeneIDi281385.
KEGGibta:281385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58500 mRNA. Translation: AAC48706.1.
PIRiJC6318.
RefSeqiNP_776564.1. NM_174139.2.
UniGeneiBt.124.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281385.
KEGGibta:281385.

Organism-specific databases

CTDi5173.

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiQ95104.
KOiK15840.

Miscellaneous databases

NextBioi20805385.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequence and expression of bovine prodynorphin."
    Jiang H., Weesner G.D., Malven P.V.
    Gene 186:279-283(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPDYN_BOVIN
AccessioniPrimary (citable) accession number: Q95104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.