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Q95104 (PDYN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin

Cleaved into the following 9 chains:

  1. Alpha-neoendorphin
  2. Beta-neoendorphin
  3. Big dynorphin
    Short name=Big Dyn
  4. Dynorphin A(1-17)
    Short name=Dyn-A17
    Short name=Dynorphin A
  5. Dynorphin A(1-13)
  6. Dynorphin A(1-8)
  7. Leu-enkephalin
  8. Rimorphin
    Alternative name(s):
    Dynorphin B
    Short name=Dyn-B
    Dynorphin B(1-13)
  9. Leumorphin
    Alternative name(s):
    Dynorphin B-29
Gene names
Name:PDYN
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.

Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.

Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity.

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEndorphin
Neuropeptide
Neurotransmitter
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 172152
PRO_0000008162
Peptide175 – 18410Alpha-neoendorphin By similarity
PRO_0000306335
Peptide175 – 1839Beta-neoendorphin
PRO_0000008163
Peptide175 – 1795Leu-enkephalin By similarity
PRO_0000306336
Propeptide186 – 20823
PRO_0000008164
Peptide211 – 24232Big dynorphin By similarity
PRO_0000306337
Peptide211 – 22717Dynorphin A(1-17)
PRO_0000008165
Peptide211 – 22313Dynorphin A(1-13) By similarity
PRO_0000306338
Peptide211 – 2188Dynorphin A(1-8) By similarity
PRO_0000306339
Peptide211 – 2155Leu-enkephalin By similarity
PRO_0000306340
Peptide230 – 25829Leumorphin By similarity
PRO_0000008166
Peptide230 – 24213Rimorphin By similarity
PRO_0000008167
Peptide230 – 2345Leu-enkephalin
PRO_0000008168

Sequences

Sequence LengthMass (Da)Tools
Q95104 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AA51C34022F18046

FASTA25828,790
        10         20         30         40         50         60 
MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ AALQPAQEWE 

        70         80         90        100        110        120 
RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR PYLKELEKNR FLLSTPAEKN 

       130        140        150        160        170        180 
ALSSSLVEKL RGLSGRLGED AESELMGDAQ LNDGALEAEA RDSNEEEPKE QVKRYGGFLR 

       190        200        210        220        230        240 
KYPKRSSEVT GKEAGEGEGG EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV 

       250 
VTRSQEDPSA YYEELFDV 

« Hide

References

[1]"cDNA sequence and expression of bovine prodynorphin."
Jiang H., Weesner G.D., Malven P.V.
Gene 186:279-283(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58500 mRNA. Translation: AAC48706.1.
PIRJC6318.
RefSeqNP_776564.1. NM_174139.2.
UniGeneBt.124.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281385.
KEGGbta:281385.

Organism-specific databases

CTD5173.

Phylogenomic databases

eggNOGNOG46156.
HOGENOMHOG000013003.
HOVERGENHBG000063.
InParanoidQ95104.
KOK15840.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805385.

Entry information

Entry namePDYN_BOVIN
AccessionPrimary (citable) accession number: Q95104
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 22, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families