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Q95104

- PDYN_BOVIN

UniProt

Q95104 - PDYN_BOVIN

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Protein
Proenkephalin-B
Gene
PDYN
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Propeptidei21 – 172152
PRO_0000008162Add
BLAST
Peptidei175 – 18410Alpha-neoendorphin By similarity
PRO_0000306335
Peptidei175 – 1839Beta-neoendorphin
PRO_0000008163
Peptidei175 – 1795Leu-enkephalin By similarity
PRO_0000306336
Propeptidei186 – 20823
PRO_0000008164Add
BLAST
Peptidei211 – 24232Big dynorphin By similarity
PRO_0000306337Add
BLAST
Peptidei211 – 22717Dynorphin A(1-17)
PRO_0000008165Add
BLAST
Peptidei211 – 22313Dynorphin A(1-13) By similarity
PRO_0000306338Add
BLAST
Peptidei211 – 2188Dynorphin A(1-8) By similarity
PRO_0000306339
Peptidei211 – 2155Leu-enkephalin By similarity
PRO_0000306340
Peptidei230 – 25829Leumorphin By similarity
PRO_0000008166Add
BLAST
Peptidei230 – 24213Rimorphin By similarity
PRO_0000008167Add
BLAST
Peptidei230 – 2345Leu-enkephalin
PRO_0000008168

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiQ95104.
KOiK15840.

Family and domain databases

InterProi