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Q95104

- PDYN_BOVIN

UniProt

Q95104 - PDYN_BOVIN

Protein

Proenkephalin-B

Gene

PDYN

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.By similarity
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.By similarity
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-B
    Alternative name(s):
    Beta-neoendorphin-dynorphin
    Preprodynorphin
    Cleaved into the following 9 chains:
    Big dynorphin
    Short name:
    Big Dyn
    Dynorphin A(1-17)
    Short name:
    Dyn-A17
    Short name:
    Dynorphin A
    Alternative name(s):
    Dynorphin B
    Short name:
    Dyn-B
    Dynorphin B(1-13)
    Alternative name(s):
    Dynorphin B-29
    Gene namesi
    Name:PDYN
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 172152PRO_0000008162Add
    BLAST
    Peptidei175 – 18410Alpha-neoendorphinBy similarityPRO_0000306335
    Peptidei175 – 1839Beta-neoendorphinPRO_0000008163
    Peptidei175 – 1795Leu-enkephalinBy similarityPRO_0000306336
    Propeptidei186 – 20823PRO_0000008164Add
    BLAST
    Peptidei211 – 24232Big dynorphinBy similarityPRO_0000306337Add
    BLAST
    Peptidei211 – 22717Dynorphin A(1-17)PRO_0000008165Add
    BLAST
    Peptidei211 – 22313Dynorphin A(1-13)By similarityPRO_0000306338Add
    BLAST
    Peptidei211 – 2188Dynorphin A(1-8)By similarityPRO_0000306339
    Peptidei211 – 2155Leu-enkephalinBy similarityPRO_0000306340
    Peptidei230 – 25829LeumorphinBy similarityPRO_0000008166Add
    BLAST
    Peptidei230 – 24213RimorphinBy similarityPRO_0000008167Add
    BLAST
    Peptidei230 – 2345Leu-enkephalinPRO_0000008168

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46156.
    HOGENOMiHOG000013003.
    HOVERGENiHBG000063.
    InParanoidiQ95104.
    KOiK15840.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q95104-1 [UniParc]FASTAAdd to Basket

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    MVWQGLVLAA CLLALPSVTA DCLAQCSLCA VKTQDGPQPI NPLVCSLECQ    50
    AALQPAQEWE RCQGLLSFLT PFTVGLNGKE DLKSKTVLEE SSSEPAKHIR 100
    PYLKELEKNR FLLSTPAEKN ALSSSLVEKL RGLSGRLGED AESELMGDAQ 150
    LNDGALEAEA RDSNEEEPKE QVKRYGGFLR KYPKRSSEVT GKEAGEGEGG 200
    EVGHEDLYKR YGGFLRRIRP KLKWDNQKRY GGFLRRQFKV VTRSQEDPSA 250
    YYEELFDV 258
    Length:258
    Mass (Da):28,790
    Last modified:February 1, 1997 - v1
    Checksum:iAA51C34022F18046
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58500 mRNA. Translation: AAC48706.1.
    PIRiJC6318.
    RefSeqiNP_776564.1. NM_174139.2.
    UniGeneiBt.124.

    Genome annotation databases

    GeneIDi281385.
    KEGGibta:281385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58500 mRNA. Translation: AAC48706.1 .
    PIRi JC6318.
    RefSeqi NP_776564.1. NM_174139.2.
    UniGenei Bt.124.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281385.
    KEGGi bta:281385.

    Organism-specific databases

    CTDi 5173.

    Phylogenomic databases

    eggNOGi NOG46156.
    HOGENOMi HOG000013003.
    HOVERGENi HBG000063.
    InParanoidi Q95104.
    KOi K15840.

    Miscellaneous databases

    NextBioi 20805385.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence and expression of bovine prodynorphin."
      Jiang H., Weesner G.D., Malven P.V.
      Gene 186:279-283(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPDYN_BOVIN
    AccessioniPrimary (citable) accession number: Q95104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3