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Protein

Calcium-transporting ATPase

Gene

TVCA1

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:TVCA1Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 7918HelicalUniRule annotationAdd
BLAST
Transmembranei91 – 10919HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27319HelicalUniRule annotationAdd
BLAST
Transmembranei293 – 31725HelicalUniRule annotationAdd
BLAST
Transmembranei823 – 84523HelicalUniRule annotationAdd
BLAST
Transmembranei880 – 90223HelicalUniRule annotationAdd
BLAST
Transmembranei914 – 93421HelicalUniRule annotationAdd
BLAST
Transmembranei946 – 96520HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi5722.Q95060.

Structurei

3D structure databases

ProteinModelPortaliQ95060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7875Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYPAHAHTP EEVAKYFNSD LEKGLTDEQV LINREKYGVN SVPPPKRKSI
60 70 80 90 100
FSMILEQFQD PMVIILLISV VLGFIFAYFE EDPEERTTAF IEPWVIIFIL
110 120 130 140 150
VVNATIAVYQ DLNAQKSVEA LKEFTPSLAN VIRNGELREI PAVEVVCGDL
160 170 180 190 200
VDVSEGRAIS ADIRLCKFKS SMVAINESNL TGEPVPVQKS LEVVKEDAVV
210 220 230 240 250
NDRINVAYKG TPLERGGFIG IAYAVGKDTQ MGYIEETTQQ EEEVITPLQR
260 270 280 290 300
NLDNFSKYIS VGILFICVIT WFANISKFDE VGNGNRIKGG LMFFKIAISL
310 320 330 340 350
AVAAIPEGLP AVVTMTLSLG VNRMAKSNAI VTKLPAVETL GCTSVICSDK
360 370 380 390 400
TGTLTTNKMV VQVFATVIDG KSSVYQVQGK DYDPDGALAI QGQKVSNLYE
410 420 430 440 450
HKAAQMSAMV GTLANDGAII YSKEKGFGRK GEPTDAAIKV FAEKVGLPTK
460 470 480 490 500
EAEEARLKKG AVERMEDVSK YWYKEYPKVR THEFTRARKS MSCIVGKNTL
510 520 530 540 550
VMKGAFEVIL AKCDRYIEDM TGEVKPLTEA VRKEIDSCRQ EWAGKKAYRC
560 570 580 590 600
IGLAYKECTD DWNNWNIIDQ QELIKYESGC IWAGSVGILD PERPDVAQSI
610 620 630 640 650
KDCYNANIRV IMCTGDNPET ATAIARNIHM LGEHEDPTGK VFTGAAWEKM
660 670 680 690 700
NDAEKREAAK NAVVLARVEP KHKRELVGIL QEQNNVVAMT GDGVNDAPAL
710 720 730 740 750
SKADIGIAMG TGTTVAQGAA QMILSDDSFS TIVKAVREGR AIYNNTTSFI
760 770 780 790 800
RYLLTCNIGE VVCCFVSSLI GGPNLLRSTQ LLFVNLVTDG LPATALGVNP
810 820 830 840 850
AEPNVMDLPP RPKDENIITP MNLCRYIVGG VYLGLATIAA AYYHYILDPL
860 870 880 890 900
GPHLTYYEIT HYHGNPHIKE ILEDETAGTM AMTVLVIIEM FSALTAVSEH
910 920 930 940 950
VSFFQLPPHR NPKLILSICG SVLVHLLVIE LPITQKIFSV VHLNCTQWAI
960 970 980
IVLLAFPVVI IEEIFKFYIR KTQKHIHIVR E
Length:981
Mass (Da):108,287
Last modified:February 1, 1997 - v1
Checksum:i2E69BA33D3AA9B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65066 Genomic DNA. Translation: AAB17958.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65066 Genomic DNA. Translation: AAB17958.1.

3D structure databases

ProteinModelPortaliQ95060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.Q95060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ95060_TRIVA
AccessioniPrimary (citable) accession number: Q95060
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.