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Protein

Probable cation-transporting ATPase 9

Gene

TPA9

Organism
Tetrahymena thermophila
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4514-aspartylphosphate intermediateBy similarity1
Metal bindingi827MagnesiumBy similarity1
Metal bindingi831MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 9 (EC:3.6.3.-)
Gene namesi
Name:TPA9
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 28HelicalSequence analysisAdd BLAST22
Topological domaini29 – 34ExtracellularSequence analysis6
Transmembranei35 – 53HelicalSequence analysisAdd BLAST19
Topological domaini54 – 167CytoplasmicSequence analysisAdd BLAST114
Transmembranei168 – 190HelicalSequence analysisAdd BLAST23
Topological domaini191 – 193ExtracellularSequence analysis3
Transmembranei194 – 212HelicalSequence analysisAdd BLAST19
Topological domaini213 – 363CytoplasmicSequence analysisAdd BLAST151
Transmembranei364 – 383HelicalSequence analysisAdd BLAST20
Topological domaini384 – 396ExtracellularSequence analysisAdd BLAST13
Transmembranei397 – 418HelicalSequence analysisAdd BLAST22
Topological domaini419 – 887CytoplasmicSequence analysisAdd BLAST469
Transmembranei888 – 906HelicalSequence analysisAdd BLAST19
Topological domaini907 – 915ExtracellularSequence analysis9
Transmembranei916 – 931HelicalSequence analysisAdd BLAST16
Topological domaini932 – 948CytoplasmicSequence analysisAdd BLAST17
Transmembranei949 – 972HelicalSequence analysisAdd BLAST24
Topological domaini973 – 994ExtracellularSequence analysisAdd BLAST22
Transmembranei995 – 1018HelicalSequence analysisAdd BLAST24
Topological domaini1019 – 1030CytoplasmicSequence analysisAdd BLAST12
Transmembranei1031 – 1050HelicalSequence analysisAdd BLAST20
Topological domaini1051 – 1101ExtracellularSequence analysisAdd BLAST51
Transmembranei1102 – 1124HelicalSequence analysisAdd BLAST23
Topological domaini1125 – 1133CytoplasmicSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463551 – 1133Probable cation-transporting ATPase 9Add BLAST1133

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5911.EAS00952.

Structurei

3D structure databases

ProteinModelPortaliQ95050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSSIEAEM ENPIDVDKTD VEGELKIKQV TLLRENIVKK IVFFLVAIFC
60 70 80 90 100
SDRPSVLKKV FYEEVSKQEE ATHVYVLASD LTDYIEEASL KENPEEGGEK
110 120 130 140 150
SIYFVNRLQK YIYHKKQNKF RAIEYFIQGK SYSEIANNKP LATGRVDQLL
160 170 180 190 200
AYYGKSEIEI NVPSFLTLMW REFKKPINFL LYFGIIVWGI EQMYVSTAIT
210 220 230 240 250
VVFTTTINSL ICIYIRGVMQ KLKDACLNNT SVIVQRHNGQ GYQEITVASN
260 270 280 290 300
MIAPGDIVLF KREVTLPFDC VILEGSCQVT EANITGENVA IGKCQIPTDH
310 320 330 340 350
HNDIFKYESS KSHTLFQGTQ LMKIEDDILK VIVVRTGFGS YKGQIIRALL
360 370 380 390 400
YPKPFNKKFQ QQAVKLTILM ATLLLIGFLS TLSRLLDIEL PPLFIAFRFL
410 420 430 440 450
DILIYSAPPG MPMLIAITNF VGLKRLKNNQ ILGQDPNSAS QAGRIQTLCF
460 470 480 490 500
DKTGTLTEDK VDLIGYQLKG QNQTFDKIQC QDPNNISIEH KLFSICHEVT
510 520 530 540 550
KINNKLLGDL MDVKMAEFST LDIDYDHEAK QHYSKSGNKR FYCIQVNQFH
560 570 580 590 600
SEYQSMSVVC KEVDMITKEF KHYFFIKGSP EKIQSLSHVQ SSEKAQLSTL
610 620 630 640 650
INEGYRILGF GYKEIPQSEI DAFLDLSREQ QEANVQSLGF LIYKNNLKPD
660 670 680 690 700
TQEVIKEFKE ACYNIKVISG DNPITTLKIS QELEIVNRKN PTVIINFEET
710 720 730 740 750
ENVKSHLIIT EIQPDNSTQV IDFSSAQNEQ DYINKQMSYC CDAFLNNKSF
760 770 780 790 800
CFSGKAHYYF QLKAKTDHIS FKPEWVKMQD KSVQKIISFY QMLIINTNVF
810 820 830 840 850
ARTQPEQKQT IVRLLKESDQ IVCMVGDGAN DCSAIREADV GISFAEADGQ
860 870 880 890 900
FSSSYVSLST SLSCVKRVLL EGRVNLSNSV EIFKGYLQVA LLRYLGFLTL
910 920 930 940 950
AYFYSSYSSG QMDWQALASG YFLVYLILGC NTPLKKLEKS VFDDNLFSIY
960 970 980 990 1000
NVTSVLFGFT LHILSIVGCV ESLHASPIYK EVNSLDAENN FQFETQHNTV
1010 1020 1030 1040 1050
LNFNILINFF YVIISNHIGK PMKDRYYKNT IAIYYDLGLI YTCKCMILQV
1060 1070 1080 1090 1100
LLILEHTHHG LIFLILLLDQ EFSSSLTVQV YFSLPMNLFL PEEFSLNFTQ
1110 1120 1130
EVKKEKELLI CNSSSTILEV DYNLRLNYFQ QNF
Length:1,133
Mass (Da):129,669
Last modified:February 1, 1997 - v1
Checksum:i6875FFBD651BAD27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41063 mRNA. Translation: AAB08071.1.
PIRiT30302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41063 mRNA. Translation: AAB08071.1.
PIRiT30302.

3D structure databases

ProteinModelPortaliQ95050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5911.EAS00952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATX9_TETTH
AccessioniPrimary (citable) accession number: Q95050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.