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Protein

Probable cation-transporting ATPase 9

Gene

TPA9

Organism
Tetrahymena thermophila
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei451 – 45114-aspartylphosphate intermediateBy similarity
Metal bindingi827 – 8271MagnesiumBy similarity
Metal bindingi831 – 8311MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 9 (EC:3.6.3.-)
Gene namesi
Name:TPA9
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2822HelicalSequence analysisAdd
BLAST
Topological domaini29 – 346ExtracellularSequence analysis
Transmembranei35 – 5319HelicalSequence analysisAdd
BLAST
Topological domaini54 – 167114CytoplasmicSequence analysisAdd
BLAST
Transmembranei168 – 19023HelicalSequence analysisAdd
BLAST
Topological domaini191 – 1933ExtracellularSequence analysis
Transmembranei194 – 21219HelicalSequence analysisAdd
BLAST
Topological domaini213 – 363151CytoplasmicSequence analysisAdd
BLAST
Transmembranei364 – 38320HelicalSequence analysisAdd
BLAST
Topological domaini384 – 39613ExtracellularSequence analysisAdd
BLAST
Transmembranei397 – 41822HelicalSequence analysisAdd
BLAST
Topological domaini419 – 887469CytoplasmicSequence analysisAdd
BLAST
Transmembranei888 – 90619HelicalSequence analysisAdd
BLAST
Topological domaini907 – 9159ExtracellularSequence analysis
Transmembranei916 – 93116HelicalSequence analysisAdd
BLAST
Topological domaini932 – 94817CytoplasmicSequence analysisAdd
BLAST
Transmembranei949 – 97224HelicalSequence analysisAdd
BLAST
Topological domaini973 – 99422ExtracellularSequence analysisAdd
BLAST
Transmembranei995 – 101824HelicalSequence analysisAdd
BLAST
Topological domaini1019 – 103012CytoplasmicSequence analysisAdd
BLAST
Transmembranei1031 – 105020HelicalSequence analysisAdd
BLAST
Topological domaini1051 – 110151ExtracellularSequence analysisAdd
BLAST
Transmembranei1102 – 112423HelicalSequence analysisAdd
BLAST
Topological domaini1125 – 11339CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11331133Probable cation-transporting ATPase 9PRO_0000046355Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5911.EAS00952.

Structurei

3D structure databases

ProteinModelPortaliQ95050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSSIEAEM ENPIDVDKTD VEGELKIKQV TLLRENIVKK IVFFLVAIFC
60 70 80 90 100
SDRPSVLKKV FYEEVSKQEE ATHVYVLASD LTDYIEEASL KENPEEGGEK
110 120 130 140 150
SIYFVNRLQK YIYHKKQNKF RAIEYFIQGK SYSEIANNKP LATGRVDQLL
160 170 180 190 200
AYYGKSEIEI NVPSFLTLMW REFKKPINFL LYFGIIVWGI EQMYVSTAIT
210 220 230 240 250
VVFTTTINSL ICIYIRGVMQ KLKDACLNNT SVIVQRHNGQ GYQEITVASN
260 270 280 290 300
MIAPGDIVLF KREVTLPFDC VILEGSCQVT EANITGENVA IGKCQIPTDH
310 320 330 340 350
HNDIFKYESS KSHTLFQGTQ LMKIEDDILK VIVVRTGFGS YKGQIIRALL
360 370 380 390 400
YPKPFNKKFQ QQAVKLTILM ATLLLIGFLS TLSRLLDIEL PPLFIAFRFL
410 420 430 440 450
DILIYSAPPG MPMLIAITNF VGLKRLKNNQ ILGQDPNSAS QAGRIQTLCF
460 470 480 490 500
DKTGTLTEDK VDLIGYQLKG QNQTFDKIQC QDPNNISIEH KLFSICHEVT
510 520 530 540 550
KINNKLLGDL MDVKMAEFST LDIDYDHEAK QHYSKSGNKR FYCIQVNQFH
560 570 580 590 600
SEYQSMSVVC KEVDMITKEF KHYFFIKGSP EKIQSLSHVQ SSEKAQLSTL
610 620 630 640 650
INEGYRILGF GYKEIPQSEI DAFLDLSREQ QEANVQSLGF LIYKNNLKPD
660 670 680 690 700
TQEVIKEFKE ACYNIKVISG DNPITTLKIS QELEIVNRKN PTVIINFEET
710 720 730 740 750
ENVKSHLIIT EIQPDNSTQV IDFSSAQNEQ DYINKQMSYC CDAFLNNKSF
760 770 780 790 800
CFSGKAHYYF QLKAKTDHIS FKPEWVKMQD KSVQKIISFY QMLIINTNVF
810 820 830 840 850
ARTQPEQKQT IVRLLKESDQ IVCMVGDGAN DCSAIREADV GISFAEADGQ
860 870 880 890 900
FSSSYVSLST SLSCVKRVLL EGRVNLSNSV EIFKGYLQVA LLRYLGFLTL
910 920 930 940 950
AYFYSSYSSG QMDWQALASG YFLVYLILGC NTPLKKLEKS VFDDNLFSIY
960 970 980 990 1000
NVTSVLFGFT LHILSIVGCV ESLHASPIYK EVNSLDAENN FQFETQHNTV
1010 1020 1030 1040 1050
LNFNILINFF YVIISNHIGK PMKDRYYKNT IAIYYDLGLI YTCKCMILQV
1060 1070 1080 1090 1100
LLILEHTHHG LIFLILLLDQ EFSSSLTVQV YFSLPMNLFL PEEFSLNFTQ
1110 1120 1130
EVKKEKELLI CNSSSTILEV DYNLRLNYFQ QNF
Length:1,133
Mass (Da):129,669
Last modified:February 1, 1997 - v1
Checksum:i6875FFBD651BAD27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41063 mRNA. Translation: AAB08071.1.
PIRiT30302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41063 mRNA. Translation: AAB08071.1.
PIRiT30302.

3D structure databases

ProteinModelPortaliQ95050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5911.EAS00952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CU428.

Entry informationi

Entry nameiATX9_TETTH
AccessioniPrimary (citable) accession number: Q95050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.