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Q95050 (ATX9_TETTH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cation-transporting ATPase 9
EC=3.6.3.-
Gene names
Name:TPA9
OrganismTetrahymena thermophila
Taxonomic identifier5911 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length1133 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11331133Probable cation-transporting ATPase 9
PRO_0000046355

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2822Helical; Potential
Topological domain29 – 346Extracellular Potential
Transmembrane35 – 5319Helical; Potential
Topological domain54 – 167114Cytoplasmic Potential
Transmembrane168 – 19023Helical; Potential
Topological domain191 – 1933Extracellular Potential
Transmembrane194 – 21219Helical; Potential
Topological domain213 – 363151Cytoplasmic Potential
Transmembrane364 – 38320Helical; Potential
Topological domain384 – 39613Extracellular Potential
Transmembrane397 – 41822Helical; Potential
Topological domain419 – 887469Cytoplasmic Potential
Transmembrane888 – 90619Helical; Potential
Topological domain907 – 9159Extracellular Potential
Transmembrane916 – 93116Helical; Potential
Topological domain932 – 94817Cytoplasmic Potential
Transmembrane949 – 97224Helical; Potential
Topological domain973 – 99422Extracellular Potential
Transmembrane995 – 101824Helical; Potential
Topological domain1019 – 103012Cytoplasmic Potential
Transmembrane1031 – 105020Helical; Potential
Topological domain1051 – 110151Extracellular Potential
Transmembrane1102 – 112423Helical; Potential
Topological domain1125 – 11339Cytoplasmic Potential

Sites

Active site45114-aspartylphosphate intermediate By similarity
Metal binding8271Magnesium By similarity
Metal binding8311Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95050 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 6875FFBD651BAD27

FASTA1,133129,669
        10         20         30         40         50         60 
MRVSSIEAEM ENPIDVDKTD VEGELKIKQV TLLRENIVKK IVFFLVAIFC SDRPSVLKKV 

        70         80         90        100        110        120 
FYEEVSKQEE ATHVYVLASD LTDYIEEASL KENPEEGGEK SIYFVNRLQK YIYHKKQNKF 

       130        140        150        160        170        180 
RAIEYFIQGK SYSEIANNKP LATGRVDQLL AYYGKSEIEI NVPSFLTLMW REFKKPINFL 

       190        200        210        220        230        240 
LYFGIIVWGI EQMYVSTAIT VVFTTTINSL ICIYIRGVMQ KLKDACLNNT SVIVQRHNGQ 

       250        260        270        280        290        300 
GYQEITVASN MIAPGDIVLF KREVTLPFDC VILEGSCQVT EANITGENVA IGKCQIPTDH 

       310        320        330        340        350        360 
HNDIFKYESS KSHTLFQGTQ LMKIEDDILK VIVVRTGFGS YKGQIIRALL YPKPFNKKFQ 

       370        380        390        400        410        420 
QQAVKLTILM ATLLLIGFLS TLSRLLDIEL PPLFIAFRFL DILIYSAPPG MPMLIAITNF 

       430        440        450        460        470        480 
VGLKRLKNNQ ILGQDPNSAS QAGRIQTLCF DKTGTLTEDK VDLIGYQLKG QNQTFDKIQC 

       490        500        510        520        530        540 
QDPNNISIEH KLFSICHEVT KINNKLLGDL MDVKMAEFST LDIDYDHEAK QHYSKSGNKR 

       550        560        570        580        590        600 
FYCIQVNQFH SEYQSMSVVC KEVDMITKEF KHYFFIKGSP EKIQSLSHVQ SSEKAQLSTL 

       610        620        630        640        650        660 
INEGYRILGF GYKEIPQSEI DAFLDLSREQ QEANVQSLGF LIYKNNLKPD TQEVIKEFKE 

       670        680        690        700        710        720 
ACYNIKVISG DNPITTLKIS QELEIVNRKN PTVIINFEET ENVKSHLIIT EIQPDNSTQV 

       730        740        750        760        770        780 
IDFSSAQNEQ DYINKQMSYC CDAFLNNKSF CFSGKAHYYF QLKAKTDHIS FKPEWVKMQD 

       790        800        810        820        830        840 
KSVQKIISFY QMLIINTNVF ARTQPEQKQT IVRLLKESDQ IVCMVGDGAN DCSAIREADV 

       850        860        870        880        890        900 
GISFAEADGQ FSSSYVSLST SLSCVKRVLL EGRVNLSNSV EIFKGYLQVA LLRYLGFLTL 

       910        920        930        940        950        960 
AYFYSSYSSG QMDWQALASG YFLVYLILGC NTPLKKLEKS VFDDNLFSIY NVTSVLFGFT 

       970        980        990       1000       1010       1020 
LHILSIVGCV ESLHASPIYK EVNSLDAENN FQFETQHNTV LNFNILINFF YVIISNHIGK 

      1030       1040       1050       1060       1070       1080 
PMKDRYYKNT IAIYYDLGLI YTCKCMILQV LLILEHTHHG LIFLILLLDQ EFSSSLTVQV 

      1090       1100       1110       1120       1130 
YFSLPMNLFL PEEFSLNFTQ EVKKEKELLI CNSSSTILEV DYNLRLNYFQ QNF

« Hide

References

[1]"P-type ATPases in Tetrahymena."
Wang S., Gao D., Penny J., Krishna S., Takeyasu K.
Ann. N. Y. Acad. Sci. 834:158-160(1997) [PubMed: 9405804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CU428.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U41063 mRNA. Translation: AAB08071.1.
PIRT30302.

3D structure databases

ProteinModelPortalQ95050.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006544. ATPase_P-typ_unknown-pump-sp.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATX9_TETTH
AccessionPrimary (citable) accession number: Q95050
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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