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Protein

Chaperonin HSP60, mitochondrial

Gene

HSP60

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

Miscellaneous

Exists in at least five isoforms that are not related by a simple post-translational modification and may represent the products of different genes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin HSP60, mitochondrial
Short name:
Protein Cpn60
Alternative name(s):
Heat shock protein 60
groEL protein
Gene namesi
Name:HSP60
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00000050399 – 562Chaperonin HSP60, mitochondrialBy similarityAdd BLAST554

Proteomic databases

PRIDEiQ95046.

Expressioni

Inductioni

By heat shock. There are multiple isoforms that, with increasing temperature, shift in relative abundance from the more basic to the more acidic.

Structurei

3D structure databases

ProteinModelPortaliQ95046.
SMRiQ95046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSAARFAG KEIRFGTEAR QSMQKGVQRA VSAVATTLGP KGRNVIIEQS
60 70 80 90 100
YGAPKITKDG VTVAKAIEFK DPFENMGAQL VRQVCNKTND LAGDGTTTSA
110 120 130 140 150
VLVASVFSES LRCIATGTNP IDMKRGMDRA VGVILQSVAE QSRKVTSTEN
160 170 180 190 200
IVQVATISAN GDEELGRLIG QAMEKVGKDG VITTQDGKTM TTELEVVEGM
210 220 230 240 250
SIDRGYISPY FVTDAKAQKA ELEDAFVLVS AKKVSSIHTI LPALNHVVRT
260 270 280 290 300
GRPLLIIADD VESEALTTMI FNKLQGKLKI ACVKAPGFGD NKTAMMQDIA
310 320 330 340 350
IFAGARLVGE EGSGLELDAE NFDPAILGTV KKATITKDDT VLLNGGGESS
360 370 380 390 400
MVKERVELLR GLIDGETSDY NREKLQERLA KLSGGVAVIK VGGGSEVEVN
410 420 430 440 450
EKKDRITDAL CSTRAAVQEG IVPGGGVALL RASKALDSLL GDSSLTADQR
460 470 480 490 500
TGVQIIRNAV RLPAHTIVLN AGKEGAVVVE KVLENNDVTV GYDAQRDRYV
510 520 530 540 550
NMFEAGIIDP ARVVRVAITD AVSVASLMMT AEAAIVDLPK EETPAAGGMG
560
GMGGMGGMGD MY
Length:562
Mass (Da):59,411
Last modified:February 1, 1997 - v1
Checksum:iF90C705E555C0898
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti142S → N in strain: PBOL. 1
Natural varianti249R → G in strain: PBOL. 1
Natural varianti457R → P in strain: PBOL. 1
Natural varianti521A → P in strain: PBOL. 1
Natural varianti531A → T in strain: PBOL. 1
Natural varianti534A → S in strain: PBOL. 1
Natural varianti538L → F in strain: PBOL. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67473 Genomic DNA. Translation: CAA47819.1.
L08791 mRNA. Translation: AAA30203.1.
PIRiS61295.

Similar proteinsi

Entry informationi

Entry nameiCH60_TRYCR
AccessioniPrimary (citable) accession number: Q95046
Secondary accession number(s): Q27795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 31, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families