ID   CP6B5_PAPGL             Reviewed;         476 AA.
AC   Q95036;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Cytochrome P450 6B5;
DE            EC=1.14.14.1;
DE   AltName: Full=CYP6B5v1;
DE   AltName: Full=CYPVIB5;
DE   Flags: Fragment;
GN   Name=CYP6B5;
OS   Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio; Pterourus.
OX   NCBI_TaxID=45779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8901557; DOI=10.1073/pnas.93.22.12200;
RA   Hung C.F., Holzmacher R., Connolly E., Berenbaum M.R., Schuler M.A.;
RT   "Conserved promoter elements in the CYP6B gene family suggest common
RT   ancestry for cytochrome P450 monooxygenases mediating furanocoumarin
RT   detoxification.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:12200-12205(1996).
CC   -!- FUNCTION: Enables the insect to feed on furanocoumarin-producing plants
CC       and evolved as an adaptation for detoxification of xanthotoxin and
CC       other furanocoumarins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- INDUCTION: By furnocoumarin.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; U65490; AAB06743.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95036; -.
DR   SMR; Q95036; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd11056; CYP6-like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR   PANTHER; PTHR24292:SF103; CYTOCHROME P450 6A14-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN           1..>476
FT                   /note="Cytochrome P450 6B5"
FT                   /id="PRO_0000051897"
FT   BINDING         443
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   NON_TER         476
SQ   SEQUENCE   476 AA;  55102 MW;  7E6F7E733645229D CRC64;
     MLTIFIVTAT LFAILYLYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR KHLIMIYKDI
     YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN DRGVEFSEEG LGLNIFHADG
     DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG DKFIKMVEKI CDKEPEQQII PLVRKFTMAS
     ITTCAFGMEL DEEMIETLDK LDSLIFTTSY GNEIDMMYPG ILKKLNSSLF SKMIAPFFDN
     LTKTIIEQRG GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF
     YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS EMTYLTQVFH
     ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF GIHYDPKYYP DPEKFDPERF
     SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ WQVQVCIIKL LSKFRFEPST KTMSEF
//