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Q95036

- CP6B5_PAPGL

UniProt

Q95036 - CP6B5_PAPGL

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Protein
Cytochrome P450 6B5
Gene
CYP6B5
Organism
Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B5 (EC:1.14.14.1)
Alternative name(s):
CYP6B5v1
CYPVIB5
Gene namesi
Name:CYP6B5
OrganismiPapilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Taxonomic identifieri45779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›476›476Cytochrome P450 6B5
PRO_0000051897Add
BLAST

Expressioni

Inductioni

By furnocoumarin.

Structurei

3D structure databases

ProteinModelPortaliQ95036.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95036-1 [UniParc]FASTAAdd to Basket

« Hide

MLTIFIVTAT LFAILYLYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR    50
KHLIMIYKDI YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN 100
DRGVEFSEEG LGLNIFHADG DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG 150
DKFIKMVEKI CDKEPEQQII PLVRKFTMAS ITTCAFGMEL DEEMIETLDK 200
LDSLIFTTSY GNEIDMMYPG ILKKLNSSLF SKMIAPFFDN LTKTIIEQRG 250
GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF 300
YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS 350
EMTYLTQVFH ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF 400
GIHYDPKYYP DPEKFDPERF SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ 450
WQVQVCIIKL LSKFRFEPST KTMSEF 476
Length:476
Mass (Da):55,102
Last modified:February 1, 1997 - v1
Checksum:i7E6F7E733645229D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei476 – 4761

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65490 Genomic DNA. Translation: AAB06743.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65490 Genomic DNA. Translation: AAB06743.1 .

3D structure databases

ProteinModelPortali Q95036.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification."
    Hung C.F., Holzmacher R., Connolly E., Berenbaum M.R., Schuler M.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:12200-12205(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP6B5_PAPGL
AccessioniPrimary (citable) accession number: Q95036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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