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Q95036

- CP6B5_PAPGL

UniProt

Q95036 - CP6B5_PAPGL

Protein

Cytochrome P450 6B5

Gene

CYP6B5

Organism
Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6B5 (EC:1.14.14.1)
    Alternative name(s):
    CYP6B5v1
    CYPVIB5
    Gene namesi
    Name:CYP6B5
    OrganismiPapilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
    Taxonomic identifieri45779 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›476›476Cytochrome P450 6B5PRO_0000051897Add
    BLAST

    Expressioni

    Inductioni

    By furnocoumarin.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95036.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q95036-1 [UniParc]FASTAAdd to Basket

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    MLTIFIVTAT LFAILYLYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR    50
    KHLIMIYKDI YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN 100
    DRGVEFSEEG LGLNIFHADG DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG 150
    DKFIKMVEKI CDKEPEQQII PLVRKFTMAS ITTCAFGMEL DEEMIETLDK 200
    LDSLIFTTSY GNEIDMMYPG ILKKLNSSLF SKMIAPFFDN LTKTIIEQRG 250
    GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF 300
    YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS 350
    EMTYLTQVFH ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF 400
    GIHYDPKYYP DPEKFDPERF SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ 450
    WQVQVCIIKL LSKFRFEPST KTMSEF 476
    Length:476
    Mass (Da):55,102
    Last modified:February 1, 1997 - v1
    Checksum:i7E6F7E733645229D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei476 – 4761

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65490 Genomic DNA. Translation: AAB06743.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65490 Genomic DNA. Translation: AAB06743.1 .

    3D structure databases

    ProteinModelPortali Q95036.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification."
      Hung C.F., Holzmacher R., Connolly E., Berenbaum M.R., Schuler M.A.
      Proc. Natl. Acad. Sci. U.S.A. 93:12200-12205(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCP6B5_PAPGL
    AccessioniPrimary (citable) accession number: Q95036
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3