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Protein

Cytochrome P450 6B5

Gene

CYP6B5

Organism
Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B5 (EC:1.14.14.1)
Alternative name(s):
CYP6B5v1
CYPVIB5
Gene namesi
Name:CYP6B5
OrganismiPapilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Taxonomic identifieri45779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›476›476Cytochrome P450 6B5PRO_0000051897Add
BLAST

Expressioni

Inductioni

By furnocoumarin.

Structurei

3D structure databases

ProteinModelPortaliQ95036.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTIFIVTAT LFAILYLYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR
60 70 80 90 100
KHLIMIYKDI YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN
110 120 130 140 150
DRGVEFSEEG LGLNIFHADG DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG
160 170 180 190 200
DKFIKMVEKI CDKEPEQQII PLVRKFTMAS ITTCAFGMEL DEEMIETLDK
210 220 230 240 250
LDSLIFTTSY GNEIDMMYPG ILKKLNSSLF SKMIAPFFDN LTKTIIEQRG
260 270 280 290 300
GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF
310 320 330 340 350
YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS
360 370 380 390 400
EMTYLTQVFH ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF
410 420 430 440 450
GIHYDPKYYP DPEKFDPERF SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ
460 470
WQVQVCIIKL LSKFRFEPST KTMSEF
Length:476
Mass (Da):55,102
Last modified:February 1, 1997 - v1
Checksum:i7E6F7E733645229D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei476 – 4761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65490 Genomic DNA. Translation: AAB06743.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65490 Genomic DNA. Translation: AAB06743.1.

3D structure databases

ProteinModelPortaliQ95036.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification."
    Hung C.F., Holzmacher R., Connolly E., Berenbaum M.R., Schuler M.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:12200-12205(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP6B5_PAPGL
AccessioniPrimary (citable) accession number: Q95036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.