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Q95031 (CP6B6_HELAM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 6B6

EC=1.14.14.1
Alternative name(s):
CYPVIB6
Gene names
Name:CYP6B6
OrganismHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifier29058 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 6B6
PRO_0000051898

Sites

Metal binding4451Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q95031 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 28C7B95798518DB0

FASTA50457,602
        10         20         30         40         50         60 
MWIFYFPAVI SVLIVSLYFY FTRTFNYWKK RNVRGPEPTV FFGNLKDSAL PRKNMGVVME 

        70         80         90        100        110        120 
ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV FSDRGVEFSK EGLGSNLFHA 

       130        140        150        160        170        180 
DGETWRALRN RFTPIFTSGK PKNMFYLMHE GADNFIDHVS AECEKNQEFE VHSLLQTYTM 

       190        200        210        220        230        240 
STIAACAFGI SYDSIGDKVK ALDIVDKIIS EPSYAIELDM MYPGLLSKLN LSIFPTAVKN 

       250        260        270        280        290        300 
FFKSLVDNIV AQRNGKPSGR NDFMDLILEL RQLGEVTSNK YGSSASSLEI TDEVICAQAF 

       310        320        330        340        350        360 
VFYIAGYETS ATTMAYMIYQ LALSPDIQNK LIAEVDEVLK ANDGKVTYDT VKEMKYMNKA 

       370        380        390        400        410        420 
FDETLRMYSI VEPLQRKATR DYKIPGTDVV IEKDTIVLIS PRGIHYDPKY YDNPKQFNPD 

       430        440        450        460        470        480 
RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF GRLQSLLCIT KILSKFRIEP SKNTDRNLQV 

       490        500 
EPHRGLIGPK GGIRVNVVPR KLVS 

« Hide

References

[1]"Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
Ranasinghe C., Hobbs A.A.
Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64800 mRNA. Translation: AAB06441.1.

3D structure databases

ProteinModelPortalQ95031.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP6B6_HELAM
AccessionPrimary (citable) accession number: Q95031
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: December 11, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families