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Q95031

- CP6B6_HELAM

UniProt

Q95031 - CP6B6_HELAM

Protein

Cytochrome P450 6B6

Gene

CYP6B6

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6B6 (EC:1.14.14.1)
    Alternative name(s):
    CYPVIB6
    Gene namesi
    Name:CYP6B6
    OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
    Taxonomic identifieri29058 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 6B6PRO_0000051898Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ95031.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95031-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWIFYFPAVI SVLIVSLYFY FTRTFNYWKK RNVRGPEPTV FFGNLKDSAL    50
    PRKNMGVVME ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV 100
    FSDRGVEFSK EGLGSNLFHA DGETWRALRN RFTPIFTSGK PKNMFYLMHE 150
    GADNFIDHVS AECEKNQEFE VHSLLQTYTM STIAACAFGI SYDSIGDKVK 200
    ALDIVDKIIS EPSYAIELDM MYPGLLSKLN LSIFPTAVKN FFKSLVDNIV 250
    AQRNGKPSGR NDFMDLILEL RQLGEVTSNK YGSSASSLEI TDEVICAQAF 300
    VFYIAGYETS ATTMAYMIYQ LALSPDIQNK LIAEVDEVLK ANDGKVTYDT 350
    VKEMKYMNKA FDETLRMYSI VEPLQRKATR DYKIPGTDVV IEKDTIVLIS 400
    PRGIHYDPKY YDNPKQFNPD RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF 450
    GRLQSLLCIT KILSKFRIEP SKNTDRNLQV EPHRGLIGPK GGIRVNVVPR 500
    KLVS 504
    Length:504
    Mass (Da):57,602
    Last modified:February 1, 1997 - v1
    Checksum:i28C7B95798518DB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64800 mRNA. Translation: AAB06441.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64800 mRNA. Translation: AAB06441.1 .

    3D structure databases

    ProteinModelPortali Q95031.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
      Ranasinghe C., Hobbs A.A.
      Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP6B6_HELAM
    AccessioniPrimary (citable) accession number: Q95031
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3