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Q95031

- CP6B6_HELAM

UniProt

Q95031 - CP6B6_HELAM

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Protein

Cytochrome P450 6B6

Gene

CYP6B6

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B6 (EC:1.14.14.1)
Alternative name(s):
CYPVIB6
Gene namesi
Name:CYP6B6
OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifieri29058 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 6B6PRO_0000051898Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ95031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95031-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWIFYFPAVI SVLIVSLYFY FTRTFNYWKK RNVRGPEPTV FFGNLKDSAL
60 70 80 90 100
PRKNMGVVME ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV
110 120 130 140 150
FSDRGVEFSK EGLGSNLFHA DGETWRALRN RFTPIFTSGK PKNMFYLMHE
160 170 180 190 200
GADNFIDHVS AECEKNQEFE VHSLLQTYTM STIAACAFGI SYDSIGDKVK
210 220 230 240 250
ALDIVDKIIS EPSYAIELDM MYPGLLSKLN LSIFPTAVKN FFKSLVDNIV
260 270 280 290 300
AQRNGKPSGR NDFMDLILEL RQLGEVTSNK YGSSASSLEI TDEVICAQAF
310 320 330 340 350
VFYIAGYETS ATTMAYMIYQ LALSPDIQNK LIAEVDEVLK ANDGKVTYDT
360 370 380 390 400
VKEMKYMNKA FDETLRMYSI VEPLQRKATR DYKIPGTDVV IEKDTIVLIS
410 420 430 440 450
PRGIHYDPKY YDNPKQFNPD RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF
460 470 480 490 500
GRLQSLLCIT KILSKFRIEP SKNTDRNLQV EPHRGLIGPK GGIRVNVVPR

KLVS
Length:504
Mass (Da):57,602
Last modified:February 1, 1997 - v1
Checksum:i28C7B95798518DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64800 mRNA. Translation: AAB06441.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64800 mRNA. Translation: AAB06441.1 .

3D structure databases

ProteinModelPortali Q95031.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
    Ranasinghe C., Hobbs A.A.
    Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP6B6_HELAM
AccessioniPrimary (citable) accession number: Q95031
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3