Q95031 (CP6B6_HELAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 6B6
EC=1.14.14.1

Alternative name(s):
CYPVIB6

Gene names

Name:

CYP6B6

Organism

Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)

Taxonomic identifier

29058 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Amphiesmenoptera › Lepidoptera › Glossata › Neolepidoptera › Heteroneura › Ditrysia › Obtectomera › Noctuoidea › Noctuidae › Heliothinae › Helicoverpa

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Cytochrome P450 6B6		PRO_0000051898
Sites
	Metal binding	445	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q95031 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 28C7B95798518DB0	FASTA	504	57,602
	10 20 30 40 50 60 MWIFYFPAVI SVLIVSLYFY FTRTFNYWKK RNVRGPEPTV FFGNLKDSAL PRKNMGVVME 70 80 90 100 110 120 ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV FSDRGVEFSK EGLGSNLFHA 130 140 150 160 170 180 DGETWRALRN RFTPIFTSGK PKNMFYLMHE GADNFIDHVS AECEKNQEFE VHSLLQTYTM 190 200 210 220 230 240 STIAACAFGI SYDSIGDKVK ALDIVDKIIS EPSYAIELDM MYPGLLSKLN LSIFPTAVKN 250 260 270 280 290 300 FFKSLVDNIV AQRNGKPSGR NDFMDLILEL RQLGEVTSNK YGSSASSLEI TDEVICAQAF 310 320 330 340 350 360 VFYIAGYETS ATTMAYMIYQ LALSPDIQNK LIAEVDEVLK ANDGKVTYDT VKEMKYMNKA 370 380 390 400 410 420 FDETLRMYSI VEPLQRKATR DYKIPGTDVV IEKDTIVLIS PRGIHYDPKY YDNPKQFNPD 430 440 450 460 470 480 RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF GRLQSLLCIT KILSKFRIEP SKNTDRNLQV 490 500 EPHRGLIGPK GGIRVNVVPR KLVS

References

[1]

"Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance." Ranasinghe C., Hobbs A.A. Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64800 mRNA. Translation: AAB06441.1.
3D structure databases
ProteinModelPortal	Q95031.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP6B6_HELAM

Accession

Primary (citable) accession number: Q95031

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)