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Q95008 (PSA5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-5

Short name=Proteasome subunit alpha 5
EC=3.4.25.1
Gene names
Name:pas-5
ORF Names:F25H2.9
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

pas-4Q950053EBI-320441,EBI-316796

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Proteasome subunit alpha type-5
PRO_0000124120

Sequences

Sequence LengthMass (Da)Tools
Q95008 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EFE50A1EB8546470

FASTA24827,207
        10         20         30         40         50         60 
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA VKLGSTSIGI KTSEGVLLAA EKRSTSKLMV 

        70         80         90        100        110        120 
NDAIEKISKV DQHIGVTFAG LIADSRTLVE RAQIEAQNFW FTYNRKIRVE DVTQSVANLA 

       130        140        150        160        170        180 
LQFGDDDVKA SMSRPFGVAM LFAGVDQEGA KLFHLDPSGT FIDCKAKSIG AASDGAEQNL 

       190        200        210        220        230        240 
KEQYHDALTI KEGLKMALAI LKQVMEEKLN SANVEVVVIK PTVDAKGRPI GEFTRVSNEE 


LDQVITSL 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z79754 Genomic DNA. Translation: CAB02097.1.
PIRT21350.
RefSeqNP_492765.1. NM_060364.6.
UniGeneCel.18396.

3D structure databases

ProteinModelPortalQ95008.
SMRQ95008. Positions 8-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid38356. 5 interactions.
DIPDIP-24675N.
IntActQ95008. 4 interactions.
MINTMINT-212111.
STRING6239.F25H2.9.

2D gel databases

World-2DPAGE0020:Q95008.

Proteomic databases

PaxDbQ95008.
PRIDEQ95008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF25H2.9.1; F25H2.9.1; WBGene00003926.
F25H2.9.2; F25H2.9.2; WBGene00003926.
GeneID172942.
KEGGcel:CELE_F25H2.9.
UCSCF25H2.9. c. elegans.

Organism-specific databases

CTD172942.
WormBaseF25H2.9; CE09654; WBGene00003926; pas-5.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00550000074958.
HOGENOMHOG000091085.
InParanoidQ95008.
KOK02729.
OMACAMSGLT.
PhylomeDBQ95008.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio877617.
PROQ95008.

Entry information

Entry namePSA5_CAEEL
AccessionPrimary (citable) accession number: Q95008
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase