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Q95008

- PSA5_CAEEL

UniProt

Q95008 - PSA5_CAEEL

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Protein

Proteasome subunit alpha type-5

Gene

pas-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Short name:
Proteasome subunit alpha 5
Gene namesi
Name:pas-5
ORF Names:F25H2.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF25H2.9; CE09654; WBGene00003926; pas-5.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Proteasome subunit alpha type-5PRO_0000124120Add
BLAST

Proteomic databases

PaxDbiQ95008.
PRIDEiQ95008.

2D gel databases

World-2DPAGE0020:Q95008.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
pas-4Q950053EBI-320441,EBI-316796

Protein-protein interaction databases

BioGridi38356. 5 interactions.
DIPiDIP-24675N.
IntActiQ95008. 4 interactions.
MINTiMINT-212111.
STRINGi6239.F25H2.9.

Structurei

3D structure databases

ProteinModelPortaliQ95008.
SMRiQ95008. Positions 8-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074958.
HOGENOMiHOG000091085.
InParanoidiQ95008.
KOiK02729.
OMAiCAMSGLT.
PhylomeDBiQ95008.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95008-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA VKLGSTSIGI KTSEGVLLAA
60 70 80 90 100
EKRSTSKLMV NDAIEKISKV DQHIGVTFAG LIADSRTLVE RAQIEAQNFW
110 120 130 140 150
FTYNRKIRVE DVTQSVANLA LQFGDDDVKA SMSRPFGVAM LFAGVDQEGA
160 170 180 190 200
KLFHLDPSGT FIDCKAKSIG AASDGAEQNL KEQYHDALTI KEGLKMALAI
210 220 230 240
LKQVMEEKLN SANVEVVVIK PTVDAKGRPI GEFTRVSNEE LDQVITSL
Length:248
Mass (Da):27,207
Last modified:February 1, 1997 - v1
Checksum:iEFE50A1EB8546470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02097.1.
PIRiT21350.
RefSeqiNP_492765.1. NM_060364.6.
UniGeneiCel.18396.

Genome annotation databases

EnsemblMetazoaiF25H2.9.1; F25H2.9.1; WBGene00003926.
F25H2.9.2; F25H2.9.2; WBGene00003926.
GeneIDi172942.
KEGGicel:CELE_F25H2.9.
UCSCiF25H2.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02097.1 .
PIRi T21350.
RefSeqi NP_492765.1. NM_060364.6.
UniGenei Cel.18396.

3D structure databases

ProteinModelPortali Q95008.
SMRi Q95008. Positions 8-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38356. 5 interactions.
DIPi DIP-24675N.
IntActi Q95008. 4 interactions.
MINTi MINT-212111.
STRINGi 6239.F25H2.9.

2D gel databases

World-2DPAGE 0020:Q95008.

Proteomic databases

PaxDbi Q95008.
PRIDEi Q95008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F25H2.9.1 ; F25H2.9.1 ; WBGene00003926 .
F25H2.9.2 ; F25H2.9.2 ; WBGene00003926 .
GeneIDi 172942.
KEGGi cel:CELE_F25H2.9.
UCSCi F25H2.9. c. elegans.

Organism-specific databases

CTDi 172942.
WormBasei F25H2.9 ; CE09654 ; WBGene00003926 ; pas-5.

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00550000074958.
HOGENOMi HOG000091085.
InParanoidi Q95008.
KOi K02729.
OMAi CAMSGLT.
PhylomeDBi Q95008.

Enzyme and pathway databases

Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

NextBioi 877617.
PROi Q95008.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSA5_CAEEL
AccessioniPrimary (citable) accession number: Q95008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3