Glutathione peroxidase precursor - Caenorhabditis elegans

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Reviewed, UniProtKB/Swiss-Prot Q95003 (GPX3_CAEEL)

Last modified January 19, 2010. Version 66. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Glutathione peroxidase
EC=1.11.1.9

Gene names

ORF Names:

C11E4.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.
Subcellular location	Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

18

Potential

Chain

206

Glutathione peroxidase

PRO_0000013090

Sites

Active site

1

By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q95003-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F02D055246EDE2F1
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224

25,556

        10         20         30         40         50         60 
MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ GEYTDLSQYR 

        70         80         90        100        110        120 
GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP CNQFYLQEPA ENHELMNGLT 

       130        140        150        160        170        180 
YVRPGNGWTP HQELHIYGKI DVNGDNHHPL YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD 

       190        200        210        220 
ITWNFEKFLI DRNGQPRFRF HPTAWSHGDV VTPFIEQLLA EPAN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81015 Genomic DNA. Translation: CAB02655.1.
PIR	T19190.
RefSeq	NP_509616.1.
UniGene	Cel.33165
3D structure databases
SMR	Q95003. Positions 39-223.
ModBase	Search...
Protein-protein interaction databases
STRING	Q95003.
Protein family/group databases
PeroxiBase	3748. CelGPx03.
Genome annotation databases
Ensembl	C11E4.2; C11E4.2; C11E4.2; Caenorhabditis elegans. [Genome view]
GeneID	182513.
KEGG	cel:C11E4.2.
NMPDR	fig\|6239.3.peg.24262.
UCSC	C11E4.2. c. elegans.
Organism-specific databases
CTD	182513.
WormBase	WBGene00007517. C11E4.2.
WormPep	C11E4.2. CE08102. [WorfDB]
Phylogenomic databases
eggNOG	meNOG14317.
HOGENOM	HBG648990.
InParanoid	Q95003.
OMA	RWHHRTT.
PhylomeDB	Q95003.
Enzyme and pathway databases
BRENDA	1.11.1.9. 672.
Gene expression databases
ArrayExpress	Q95003.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	917856.

Entry information

Entry name

GPX3_CAEEL

Accession

Primary (citable) accession number: Q95003

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	January 19, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents