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Protein

Glutathione peroxidase 3

Gene

gpx-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-74259. Purine catabolism.

Protein family/group databases

PeroxiBasei3748. CelGPx03.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 3 (EC:1.11.1.9)
Gene namesi
Name:gpx-3
ORF Names:C11E4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC11E4.2; CE08102; WBGene00007517; gpx-3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 224206Glutathione peroxidase 3PRO_0000013090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ95003.
PaxDbiQ95003.
PRIDEiQ95003.

Interactioni

Protein-protein interaction databases

STRINGi6239.C11E4.2.

Structurei

3D structure databases

ProteinModelPortaliQ95003.
SMRiQ95003. Positions 39-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
InParanoidiQ95003.
KOiK00432.
OMAiRWYHRAT.
OrthoDBiEOG7KQ23C.
PhylomeDBiQ95003.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ
60 70 80 90 100
GEYTDLSQYR GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP
110 120 130 140 150
CNQFYLQEPA ENHELMNGLT YVRPGNGWTP HQELHIYGKI DVNGDNHHPL
160 170 180 190 200
YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD ITWNFEKFLI DRNGQPRFRF
210 220
HPTAWSHGDV VTPFIEQLLA EPAN
Length:224
Mass (Da):25,556
Last modified:February 1, 1997 - v1
Checksum:iF02D055246EDE2F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81015 Genomic DNA. Translation: CAB02655.1.
PIRiT19190.
RefSeqiNP_509616.1. NM_077215.4.
UniGeneiCel.33165.

Genome annotation databases

EnsemblMetazoaiC11E4.2; C11E4.2; WBGene00007517.
GeneIDi182513.
KEGGicel:CELE_C11E4.2.
UCSCiC11E4.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81015 Genomic DNA. Translation: CAB02655.1.
PIRiT19190.
RefSeqiNP_509616.1. NM_077215.4.
UniGeneiCel.33165.

3D structure databases

ProteinModelPortaliQ95003.
SMRiQ95003. Positions 39-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C11E4.2.

Protein family/group databases

PeroxiBasei3748. CelGPx03.

Proteomic databases

EPDiQ95003.
PaxDbiQ95003.
PRIDEiQ95003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC11E4.2; C11E4.2; WBGene00007517.
GeneIDi182513.
KEGGicel:CELE_C11E4.2.
UCSCiC11E4.2. c. elegans.

Organism-specific databases

CTDi182513.
WormBaseiC11E4.2; CE08102; WBGene00007517; gpx-3.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
InParanoidiQ95003.
KOiK00432.
OMAiRWYHRAT.
OrthoDBiEOG7KQ23C.
PhylomeDBiQ95003.

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-74259. Purine catabolism.

Miscellaneous databases

PROiQ95003.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGPX3_CAEEL
AccessioniPrimary (citable) accession number: Q95003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.