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Q95003 (GPX3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione peroxidase

EC=1.11.1.9
Gene names
ORF Names:C11E4.2
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Secretedextracellular space By similarity.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionOxidoreductase
Peroxidase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 224206Glutathione peroxidase
PRO_0000013090

Sites

Active site731 By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q95003 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F02D055246EDE2F1

FASTA22425,556
        10         20         30         40         50         60 
MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ GEYTDLSQYR 

        70         80         90        100        110        120 
GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP CNQFYLQEPA ENHELMNGLT 

       130        140        150        160        170        180 
YVRPGNGWTP HQELHIYGKI DVNGDNHHPL YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD 

       190        200        210        220 
ITWNFEKFLI DRNGQPRFRF HPTAWSHGDV VTPFIEQLLA EPAN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z81015 Genomic DNA. Translation: CAB02655.1.
PIRT19190.
RefSeqNP_509616.1. NM_077215.3.
UniGeneCel.33165.

3D structure databases

ProteinModelPortalQ95003.
SMRQ95003. Positions 39-223.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ95003.

Protein family/group databases

PeroxiBase3748. CelGPx03.

Proteomic databases

PRIDEQ95003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC11E4.2; C11E4.2; C11E4.2.
GeneID182513.
KEGGcel:C11E4.2.
NMPDRfig|6239.3.peg.24262.
UCSCC11E4.2. c. elegans.

Organism-specific databases

CTD182513.
WormBaseC11E4.2; CE08102; WBGene00007517.

Phylogenomic databases

eggNOGmeNOG14317.
GeneTreeEMGT00050000001082.
HOGENOMHBG648990.
InParanoidQ95003.
OMAVNVATYY.
PhylomeDBQ95003.

Gene expression databases

ArrayExpressQ95003.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK00432.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio917856.

Entry information

Entry nameGPX3_CAEEL
AccessionPrimary (citable) accession number: Q95003
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families