Q95003 (GPX3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase
EC=1.11.1.9

Gene names

ORF Names:

C11E4.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 224	206	Glutathione peroxidase		PRO_0000013090
Sites
	Active site	73	1	By similarity
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q95003 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: F02D055246EDE2F1	FASTA	224	25,556
	10 20 30 40 50 60 MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ GEYTDLSQYR 70 80 90 100 110 120 GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP CNQFYLQEPA ENHELMNGLT 130 140 150 160 170 180 YVRPGNGWTP HQELHIYGKI DVNGDNHHPL YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD 190 200 210 220 ITWNFEKFLI DRNGQPRFRF HPTAWSHGDV VTPFIEQLLA EPAN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81015 Genomic DNA. Translation: CAB02655.1.
PIR	T19190.
RefSeq	NP_509616.1. NM_077215.3.
UniGene	Cel.33165.
3D structure databases
ProteinModelPortal	Q95003.
SMR	Q95003. Positions 39-223.
ModBase	Search...
Protein-protein interaction databases
STRING	Q95003.
Protein family/group databases
PeroxiBase	3748. CelGPx03.
Proteomic databases
PRIDE	Q95003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C11E4.2; C11E4.2; C11E4.2.
GeneID	182513.
KEGG	cel:C11E4.2.
NMPDR	fig|6239.3.peg.24262.
UCSC	C11E4.2. c. elegans.
Organism-specific databases
CTD	182513.
WormBase	C11E4.2; CE08102; WBGene00007517.
Phylogenomic databases
eggNOG	meNOG14317.
GeneTree	EMGT00050000001082.
HOGENOM	HBG648990.
InParanoid	Q95003.
OMA	VNVATYY.
PhylomeDB	Q95003.
Gene expression databases
ArrayExpress	Q95003.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	917856.

Entry information

Entry name

GPX3_CAEEL

Accession

Primary (citable) accession number: Q95003

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project