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Protein

Serine/threonine-protein phosphatase

Gene

tax-6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

  • calcium ion binding Source: WormBase
  • phosphoprotein phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • dauer larval development Source: WormBase
  • determination of adult lifespan Source: WormBase
  • hyperosmotic response Source: WormBase
  • olfactory behavior Source: WormBase
  • olfactory learning Source: WormBase
  • positive regulation of growth rate Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • regulation of gene expression Source: WormBase
  • response to alkaline pH Source: UniProtKB
  • thermosensory behavior Source: WormBase
  • thermotaxis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:tax-6Imported
ORF Names:C02F4.2Imported, CELE_C02F4.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC02F4.2a; CE07853; WBGene00006527; tax-6.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • cytoplasm Source: WormBase
  • dendrite Source: WormBase
  • neuronal cell body Source: WormBase
  • nonmotile primary cilium Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ95002.
PaxDbiQ95002.
PRIDEiQ95002.

Expressioni

Gene expression databases

ExpressionAtlasiQ95002. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-25135N.
IntActiQ95002. 1 interaction.
MINTiMINT-3383953.
STRINGi6239.C02F4.2c.

Structurei

3D structure databases

ProteinModelPortaliQ95002.
SMRiQ95002. Positions 36-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 1776SER_THR_PHOSPHATASEInterPro annotation

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0375. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063087.
HOGENOMiHOG000172699.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTSAGQNS AAKPDTTNTT TTASNNNRER ERDLKQFTER FVKTVQFPVS
60 70 80 90 100
ERLTVDQVYD RRTGKPRHEV LRDHFIKEGR IEEEAAIRVI QECSSLFRNE
110 120 130 140 150
KTMLEIEAPV TVCGDIHGQF YDLMKLFEVG GSPATTKYLF LGDYVDRGYF
160 170 180 190 200
SIECVLYLWA LKICYPTTLF LLRGNHECRH LTEYFTFKQE CKIKYSERVY
210 220 230 240 250
DVCMESFDAL PLAALMNQQF LCVHGGLSPE IHTLEDIRRI DRFKEPPAFG
260 270 280 290 300
PMCDLLWSDP LEDFGNERNS EQFSHNSVRG CSYFYSYAAC CDFLQHNNLL
310 320 330 340 350
SIIRAHEAQD AGYRMYRKSQ ATGFPSLITI FSAPNYLDVY NNKAAILKYE
360 370 380 390 400
NNVMNIRQFN CSPHPYWLPN FMDVFTWSLP FVGEKVTEML VHILNICSDD
410 420 430 440 450
ELMAECDDTF EGGVGSARKE VIRHKIRAIG KMARAFSVLR EESESVLALK
460 470 480 490 500
GLTPTGALPM GTLQGGSRGV REVAAESGCD SGHLIQSFEE ARRLDKINER
510 520 530
MPPTMATPPA QSPSQSPIPS RQTTPQPPQN GPSNS
Length:535
Mass (Da):60,666
Last modified:February 1, 1997 - v1
Checksum:iFC0363809D04103E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02719.1.
PIRiT18864.
RefSeqiNP_001021292.1. NM_001026121.1.
UniGeneiCel.13613.

Genome annotation databases

EnsemblMetazoaiC02F4.2a; C02F4.2a; WBGene00006527.
GeneIDi177943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02719.1.
PIRiT18864.
RefSeqiNP_001021292.1. NM_001026121.1.
UniGeneiCel.13613.

3D structure databases

ProteinModelPortaliQ95002.
SMRiQ95002. Positions 36-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25135N.
IntActiQ95002. 1 interaction.
MINTiMINT-3383953.
STRINGi6239.C02F4.2c.

Proteomic databases

EPDiQ95002.
PaxDbiQ95002.
PRIDEiQ95002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02F4.2a; C02F4.2a; WBGene00006527.
GeneIDi177943.

Organism-specific databases

CTDi177943.
WormBaseiC02F4.2a; CE07853; WBGene00006527; tax-6.

Phylogenomic databases

eggNOGiKOG0375. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063087.
HOGENOMiHOG000172699.

Enzyme and pathway databases

ReactomeiR-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Miscellaneous databases

NextBioi899062.

Gene expression databases

ExpressionAtlasiQ95002. baseline.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ95002_CAEEL
AccessioniPrimary (citable) accession number: Q95002
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.