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Q95001 (CHLE2_BRALA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholinesterase 2

EC=3.1.1.8
Gene names
Name:CHE2
OrganismBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifier7740 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length337 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An acylcholine + H2O = choline + a carboxylate.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
   Molecular functionHydrolase
Serine esterase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Molecular_functioncholinesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›337›337Cholinesterase 2
PRO_0000070290

Sites

Active site991Acyl-ester intermediate By similarity
Active site2241Charge relay system By similarity

Amino acid modifications

Glycosylation2901N-linked (GlcNAc...) Potential
Disulfide bond153 ↔ 165 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue3371

Sequences

Sequence LengthMass (Da)Tools
Q95001 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: C9DE20A316C71258

FASTA33736,738
        10         20         30         40         50         60 
QPSPVPVGAT VMVWIYGGGF MSGTASLDVY DGRYIAATQG VIVASMNYRT GAMGFLSLGN 

        70         80         90        100        110        120 
SEAPGNAGLM DQNLALTWIK ENVASFGGDQ SKVSIFGESA GAASVSYHLL SPMSKNLFQR 

       130        140        150        160        170        180 
AIMESASALS PWALLPDAEA HRRGVELAKA VGCSTDSDIE ETIECMRGVP ALTISENEWV 

       190        200        210        220        230        240 
VWGLCQFPFA PVVDGNFIRE HPTVSLQTGN LKQTDVMVGF NNDEGVYFLL YGAPGFSKDT 

       250        260        270        280        290        300 
QSLITRDQYL EGIKMSVMGI NDISVDALSF QYIDWVNFDQ PSMYRDAIDN LSGDYNFICP 

       310        320        330 
ALSFGKAMAS FMGRKTYQYK FVHQASNFPW PKWTGVM 

« Hide

References

[1]"Two cholinesterase activities and genes are present in amphioxus."
Sutherland D., McClellan J.S., Milner D., Soong W., Axon N., Sanders M., Hester A., Kao Y.H., Poczatek T., Routt S., Pezzementi L.
J. Exp. Zool. 277:213-229(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U74379 Genomic DNA. Translation: AAB18263.1.

3D structure databases

ProteinModelPortalQ95001.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008839.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00878. CHOLNESTRASE.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHLE2_BRALA
AccessionPrimary (citable) accession number: Q95001
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families