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Q95001

- CHLE2_BRALA

UniProt

Q95001 - CHLE2_BRALA

Protein

Cholinesterase 2

Gene

CHE2

Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An acylcholine + H2O = choline + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei224 – 2241Charge relay systemBy similarity

    GO - Molecular functioni

    1. cholinesterase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Protein family/group databases

    MEROPSiS09.980.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholinesterase 2 (EC:3.1.1.8)
    Gene namesi
    Name:CHE2
    OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
    Taxonomic identifieri7740 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›337›337Cholinesterase 2PRO_0000070290Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi153 ↔ 165By similarity
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ95001.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG008839.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q95001-1 [UniParc]FASTAAdd to Basket

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    QPSPVPVGAT VMVWIYGGGF MSGTASLDVY DGRYIAATQG VIVASMNYRT    50
    GAMGFLSLGN SEAPGNAGLM DQNLALTWIK ENVASFGGDQ SKVSIFGESA 100
    GAASVSYHLL SPMSKNLFQR AIMESASALS PWALLPDAEA HRRGVELAKA 150
    VGCSTDSDIE ETIECMRGVP ALTISENEWV VWGLCQFPFA PVVDGNFIRE 200
    HPTVSLQTGN LKQTDVMVGF NNDEGVYFLL YGAPGFSKDT QSLITRDQYL 250
    EGIKMSVMGI NDISVDALSF QYIDWVNFDQ PSMYRDAIDN LSGDYNFICP 300
    ALSFGKAMAS FMGRKTYQYK FVHQASNFPW PKWTGVM 337
    Length:337
    Mass (Da):36,738
    Last modified:February 1, 1997 - v1
    Checksum:iC9DE20A316C71258
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei337 – 3371

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74379 Genomic DNA. Translation: AAB18263.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74379 Genomic DNA. Translation: AAB18263.1 .

    3D structure databases

    ProteinModelPortali Q95001.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG008839.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCHLE2_BRALA
    AccessioniPrimary (citable) accession number: Q95001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3