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Q95001

- CHLE2_BRALA

UniProt

Q95001 - CHLE2_BRALA

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Protein

Cholinesterase 2

Gene

CHE2

Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei224 – 2241Charge relay systemBy similarity

GO - Molecular functioni

  1. cholinesterase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase 2 (EC:3.1.1.8)
Gene namesi
Name:CHE2
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›337›337Cholinesterase 2PRO_0000070290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi153 ↔ 165By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ95001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QPSPVPVGAT VMVWIYGGGF MSGTASLDVY DGRYIAATQG VIVASMNYRT
60 70 80 90 100
GAMGFLSLGN SEAPGNAGLM DQNLALTWIK ENVASFGGDQ SKVSIFGESA
110 120 130 140 150
GAASVSYHLL SPMSKNLFQR AIMESASALS PWALLPDAEA HRRGVELAKA
160 170 180 190 200
VGCSTDSDIE ETIECMRGVP ALTISENEWV VWGLCQFPFA PVVDGNFIRE
210 220 230 240 250
HPTVSLQTGN LKQTDVMVGF NNDEGVYFLL YGAPGFSKDT QSLITRDQYL
260 270 280 290 300
EGIKMSVMGI NDISVDALSF QYIDWVNFDQ PSMYRDAIDN LSGDYNFICP
310 320 330
ALSFGKAMAS FMGRKTYQYK FVHQASNFPW PKWTGVM
Length:337
Mass (Da):36,738
Last modified:February 1, 1997 - v1
Checksum:iC9DE20A316C71258
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei337 – 3371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74379 Genomic DNA. Translation: AAB18263.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74379 Genomic DNA. Translation: AAB18263.1 .

3D structure databases

ProteinModelPortali Q95001.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008839.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHLE2_BRALA
AccessioniPrimary (citable) accession number: Q95001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3