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Q95000 (CHLE1_BRALA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholinesterase 1

EC=3.1.1.8
Gene names
Name:CHE1
OrganismBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifier7740 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length357 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An acylcholine + H2O = choline + a carboxylate.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
   Molecular functionHydrolase
Serine esterase
   PTMDisulfide bond
Gene Ontology (GO)
   Molecular_functioncholinesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›357›357Cholinesterase 1
PRO_0000070289

Sites

Active site1121Acyl-ester intermediate By similarity
Active site2441Charge relay system By similarity
Active site3571Charge relay system By similarity

Amino acid modifications

Disulfide bond166 ↔ 179 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue3571

Sequences

Sequence LengthMass (Da)Tools
Q95000 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A2CBDE841704DCDF

FASTA35739,462
        10         20         30         40         50         60 
TPISEDCLYL NVWQPSPAPT GATVLVWIYG GGFFSGTSSL DVYDGRYLAR MEDVVVVSMN 

        70         80         90        100        110        120 
YRLGALGFLY TGSEAAPGNA GLLDQHLALQ WVQQNIQSFG GDPGKVTIFG ESAGAASVNF 

       130        140        150        160        170        180 
HMLSPMSRDL FQRAMMHSAS ALAPWAVTPS EQARQRSKAL AIDIGCSADE EDMDVLVACL 

       190        200        210        220        230        240 
REVSAQTILD HEWNVVDLSD AHFLADIPFP PVKDGRFITE DPAEMYAAGN FKDIDILVGF 

       250        260        270        280        290        300 
VKDEGNFWLV YGVPGFDKDT DSIIDRETFV GDIVFCHPRL NDITVERTAF EYTDWLHMDQ 

       310        320        330        340        350 
DTMYRDALDS VFGDPFFVCP TMAVGKAHVN HGRTAYVYEF AQVASNLAWP HWMGAMH 

« Hide

References

[1]"Two cholinesterase activities and genes are present in amphioxus."
Sutherland D., McClellan J.S., Milner D., Soong W., Axon N., Sanders M., Hester A., Kao Y.H., Poczatek T., Routt S., Pezzementi L.
J. Exp. Zool. 277:213-229(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U74378 Genomic DNA. Translation: AAB18262.1.

3D structure databases

ProteinModelPortalQ95000.
SMRQ95000. Positions 2-357.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008839.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00878. CHOLNESTRASE.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHLE1_BRALA
AccessionPrimary (citable) accession number: Q95000
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families