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Protein

Cholinesterase 1

Gene

CHE1

Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei244Charge relay systemBy similarity1
Active sitei357Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase 1 (EC:3.1.1.8)
Gene namesi
Name:CHE1
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000070289‹1 – ›357Cholinesterase 1Add BLAST›357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi166 ↔ 179By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ95000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TPISEDCLYL NVWQPSPAPT GATVLVWIYG GGFFSGTSSL DVYDGRYLAR
60 70 80 90 100
MEDVVVVSMN YRLGALGFLY TGSEAAPGNA GLLDQHLALQ WVQQNIQSFG
110 120 130 140 150
GDPGKVTIFG ESAGAASVNF HMLSPMSRDL FQRAMMHSAS ALAPWAVTPS
160 170 180 190 200
EQARQRSKAL AIDIGCSADE EDMDVLVACL REVSAQTILD HEWNVVDLSD
210 220 230 240 250
AHFLADIPFP PVKDGRFITE DPAEMYAAGN FKDIDILVGF VKDEGNFWLV
260 270 280 290 300
YGVPGFDKDT DSIIDRETFV GDIVFCHPRL NDITVERTAF EYTDWLHMDQ
310 320 330 340 350
DTMYRDALDS VFGDPFFVCP TMAVGKAHVN HGRTAYVYEF AQVASNLAWP

HWMGAMH
Length:357
Mass (Da):39,462
Last modified:February 1, 1997 - v1
Checksum:iA2CBDE841704DCDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei3571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74378 Genomic DNA. Translation: AAB18262.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74378 Genomic DNA. Translation: AAB18262.1.

3D structure databases

ProteinModelPortaliQ95000.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHLE1_BRALA
AccessioniPrimary (citable) accession number: Q95000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 5, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.