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Q95000

- CHLE1_BRALA

UniProt

Q95000 - CHLE1_BRALA

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Protein

Cholinesterase 1

Gene

CHE1

Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei244 – 2441Charge relay systemBy similarity
Active sitei357 – 3571Charge relay systemBy similarity

GO - Molecular functioni

  1. cholinesterase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase 1 (EC:3.1.1.8)
Gene namesi
Name:CHE1
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›357›357Cholinesterase 1PRO_0000070289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi166 ↔ 179By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ95000.
SMRiQ95000. Positions 2-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q95000 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TPISEDCLYL NVWQPSPAPT GATVLVWIYG GGFFSGTSSL DVYDGRYLAR
60 70 80 90 100
MEDVVVVSMN YRLGALGFLY TGSEAAPGNA GLLDQHLALQ WVQQNIQSFG
110 120 130 140 150
GDPGKVTIFG ESAGAASVNF HMLSPMSRDL FQRAMMHSAS ALAPWAVTPS
160 170 180 190 200
EQARQRSKAL AIDIGCSADE EDMDVLVACL REVSAQTILD HEWNVVDLSD
210 220 230 240 250
AHFLADIPFP PVKDGRFITE DPAEMYAAGN FKDIDILVGF VKDEGNFWLV
260 270 280 290 300
YGVPGFDKDT DSIIDRETFV GDIVFCHPRL NDITVERTAF EYTDWLHMDQ
310 320 330 340 350
DTMYRDALDS VFGDPFFVCP TMAVGKAHVN HGRTAYVYEF AQVASNLAWP

HWMGAMH
Length:357
Mass (Da):39,462
Last modified:February 1, 1997 - v1
Checksum:iA2CBDE841704DCDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei357 – 3571

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74378 Genomic DNA. Translation: AAB18262.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74378 Genomic DNA. Translation: AAB18262.1 .

3D structure databases

ProteinModelPortali Q95000.
SMRi Q95000. Positions 2-357.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008839.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHLE1_BRALA
AccessioniPrimary (citable) accession number: Q95000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3