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Reviewed, UniProtKB/Swiss-Prot Q94WR7 (COX1_BUTBU)

Last modified October 13, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I
Gene names
Name: MT-CO1
Synonyms: COI, COXI, MTCO1
Encoded onMitochondrion
OrganismButeo buteo (Common buzzard)
Taxonomic identifier30397 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Falconiformes › Accipitridae › Accipitrinae › Buteo

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Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Cytochrome c oxidase subunit 1
PRO_0000183297

Regions

Transmembrane18 – 3821 Potential
Transmembrane57 – 7721 Potential
Transmembrane103 – 12321 Potential
Transmembrane146 – 16621 Potential
Transmembrane184 – 20421 Potential
Transmembrane235 – 25521 Potential
Transmembrane269 – 28921 Potential
Transmembrane311 – 33121 Potential
Transmembrane339 – 35921 Potential
Transmembrane381 – 40121 Potential
Transmembrane415 – 43521 Potential
Transmembrane457 – 47721 Potential

Sites

Metal binding621Iron (heme A axial ligand) Probable
Metal binding2411Copper B Probable
Metal binding2451Copper B Probable
Metal binding2911Copper B Probable
Metal binding2921Copper B Probable
Metal binding3771Iron (heme A3 axial ligand) Probable
Metal binding3791Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q94WR7-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 316F597BAE8FFD88

FASTA51656,925
        10         20         30         40         50         60 
MTFINRWLFS TNHKDIGTLY LIFGAWAGMV GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 

        70         80         90        100        110        120 
AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTVE 

       130        140        150        160        170        180 
AGAGTGWTVY PPLAGNMAHA GASVDLAIFS LHLAGVSSIL GAINFITTAI NMKPPALSQY 

       190        200        210        220        230        240 
QTPLFVWSVL ITAVLLLLSL PVLAAGITML LTDRNLNTTF FDPAGGGDPI LYQHLFWFFG 

       250        260        270        280        290        300 
HPEVYILILP GFGIISHVVT YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV 

       310        320        330        340        350        360 
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDPPML WALGFIFLFT IGGLTGIVLA 

       370        380        390        400        410        420 
NSSLDIALHD AYYVVAHFHY VLSMGAVFAI LAGFTHWFPL LTGFTLHPTW AKAHFGVMFT 

       430        440        450        460        470        480 
GVNLTFFPQH FLGLAGMPRR YSDYPDAYTL WNTLSSIGSL ISMTAVIMLM FIIWEAFASK 

       490        500        510 
RKILQPELTT TNVEWIHGCP PPYHTFEEPA FVQVQE

« Hide

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References

[1]"The complete sequence of the mitochondrial genome of Buteo buteo (Aves, Accipitridae) indicates an early split in the phylogeny of raptors."
Haring E., Kruckenhauser L., Gamauf A., Riesing M.J., Pinsker W.
Mol. Biol. Evol. 18:1892-1904(2001) [PubMed: 11557795] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

AF380305 Genomic DNA. Translation: AAL11083.1.
RefSeqNP_387487.1.

3D structure databases

HSSPHSSP built from PDB template 2OCC based on UniProtKB P00396.
SMRQ94WR7. Positions 3-515.
ModBaseSearch...

Genome annotation databases

GeneID803916.

Organism-specific databases

CTD803916.

Phylogenomic databases

HOVERGENQ94WR7.

Enzyme and pathway databases

BRENDA1.9.3.1. 300976.

Family and domain databases

InterProIPR000883. Cyt_c_oxidase_su1.
[Graphical view]
Gene3DG3DSA:1.20.210.10. COX1. 1 hit.
PANTHERPTHR10422. COX1. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCOX1_BUTBU
AccessionPrimary (citable) accession number: Q94WR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: October 13, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents