Q94NW9 (ATP8_FELLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase protein 8

Alternative name(s):
A6L
F-ATPase subunit 8

Gene names

Name:	MT-ATP8
Synonyms:	ATP8, ATPASE8, MTATP8

Encoded on

Mitochondrion

Organism

Felis libyca (African steppe cat) (Libyan wildcat)

Taxonomic identifier

61377 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel By similarity.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the ATPase protein 8 family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 67	67	ATP synthase protein 8		PRO_0000247811
Regions
	Transmembrane	8 – 24	17	Helical; Potential
Amino acid modifications
	Modified residue	54	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q94NW9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 955499A55C2EFCD0	FASTA	67	7,923
	10 20 30 40 50 60 MPQLDTSTWS ITIMSMIMTL FIVFQLKISK YLYPSNPEPK SMTTLKQLNP WEKKWTKIYS PLSLPQQ

References

[1]	"Genetic identification of wild and domestic cats (Felis silvestris) and their hybrids using Bayesian clustering methods." Randi E., Pierpaoli M., Beaumont M., Ragni B., Sforzi A. Mol. Biol. Evol. 18:1679-1693(2001) [PubMed: 11504848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ409135 Genomic DNA. Translation: CAC41049.1. AJ409140 Genomic DNA. Translation: CAC41064.1. AJ409142 Genomic DNA. Translation: CAC41070.1. AJ409144 Genomic DNA. Translation: CAC41076.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG017400.
Family and domain databases
InterPro	IPR001421. ATPase_F0-cplx_su8_mt_metazoan. [Graphical view]
Pfam	PF00895. ATP-synt_8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP8_FELLI

Accession

Primary (citable) accession number: Q94NW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	December 1, 2001
Last modified:	January 11, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program