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Protein

Profilin

Gene
N/A
Organism
Musa acuminata (Banana) (Musa cavendishii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Alternative name(s):
Minor fruit allergen Mus xp 1
Allergen: Mus xp 1
OrganismiMusa acuminata (Banana) (Musa cavendishii)
Taxonomic identifieri4641 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMusaceaeMusa

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. This is a food allergen.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei7632. Mus a 1.
7633. Mus a 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 131130ProfilinPRO_0000199655Add
BLAST

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

STRINGi4641.GSMUA_Achr3P17580_001.

Structurei

3D structure databases

ProteinModelPortaliQ94JN3.
SMRiQ94JN3. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94JN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LLCDIDGQCL TAAAIVGHDG SVWAQSDAFP QCKPEEIAAI
60 70 80 90 100
MKDFDEPGSL APTGLYLGGT KYMVIQGEPG AVIRGKKGSG GVTIKKTNLA
110 120 130
LIIGIYNEPM TPGQCNMVVE RLGDYLFDQG F
Length:131
Mass (Da):14,042
Last modified:December 1, 2001 - v1
Checksum:i583A49241651F3E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377948 mRNA. Translation: AAK54834.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377948 mRNA. Translation: AAK54834.1.

3D structure databases

ProteinModelPortaliQ94JN3.
SMRiQ94JN3. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4641.GSMUA_Achr3P17580_001.

Protein family/group databases

Allergomei7632. Mus a 1.
7633. Mus a 1.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple."
    Reindl J., Rihs H.P., Scheurer S., Wangorsch A., Haustein D., Vieths S.
    Int. Arch. Allergy Immunol. 128:105-114(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Entry informationi

Entry nameiPROF_MUSAC
AccessioniPrimary (citable) accession number: Q94JN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.