Q94JN2 (PROF_ANACO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Profilin Alternative name(s): Minor food allergen Ana c 1 Allergen=Ana c 1
Organism	Ananas comosus (Pineapple) (Ananas ananas)
Taxonomic identifier	4615 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Bromeliaceae › Ananas

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. This is a food allergen. Ref.1
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin		PRO_0000199612

Sequences

	Sequence		Length	Mass (Da)
	Q94JN2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D3C05FC6B70ABD98	FASTA	131	14,229
	10 20 30 40 50 60 MSWQAYVDDH LMCEIDGQHL SSAAILGHDS TVWAQSPNFP QFKPEEISAI LNDFENPGSL 70 80 90 100 110 120 APTGLYLGGT KYMVIQGEPG VVIRGKKGTG GITVKKTNLA LIIGVYDEPM TPGQCNMVVE 130 RLGDYLLEQG F

References

[1]	"IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple." Reindl J., Rihs H.P., Scheurer S., Wangorsch A., Haustein D., Vieths S. Int. Arch. Allergy Immunol. 128:105-114(2002) [PubMed: 12065910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF377949 mRNA. Translation: AAK54835.1.
3D structure databases
ProteinModelPortal	Q94JN2.
SMR	Q94JN2. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	3075. Ana c 1.0101. 33. Ana c 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002097. Profilin. IPR005455. Profilin_plant. [Graphical view]
PANTHER	PTHR11604. Profilin_plant. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF_ANACO

Accession

Primary (citable) accession number: Q94JN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	December 1, 2001
Last modified:	January 11, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program