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Protein

Ethylene-responsive transcription factor 12

Gene

ERF12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi11 – 6858AP2/ERFPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Ethylene signaling pathway, Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor 12
Short name:
AtERF12
Alternative name(s):
Ethylene-responsive element-binding factor 12
Short name:
EREBP-12
Gene namesi
Name:ERF12
Synonyms:ERF-12, ERF081
Ordered Locus Names:At1g28360
ORF Names:F3M18.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G28360.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Ethylene-responsive transcription factor 12PRO_0000112562Add
BLAST

Proteomic databases

PaxDbiQ94ID6.
PRIDEiQ94ID6.

Expressioni

Gene expression databases

GenevisibleiQ94ID6. AT.

Interactioni

Protein-protein interaction databases

BioGridi24967. 13 interactions.
IntActiQ94ID6. 11 interactions.
STRINGi3702.AT1G28360.1.

Structurei

3D structure databases

ProteinModelPortaliQ94ID6.
SMRiQ94ID6. Positions 11-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi179 – 1857EAR-like (transcriptional repression)

Domaini

Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 AP2/ERF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZFN. Eukaryota.
ENOG41123N5. LUCA.
HOGENOMiHOG000237624.
InParanoidiQ94ID6.
OMAiMASTTCA.
PhylomeDBiQ94ID6.

Family and domain databases

Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94ID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTCAREV HYRGVRKRPW GRYAAEIRDP WKKTRVWLGT FDTPEEAALA
60 70 80 90 100
YDGAARFLRG IKAKTNFPSP LSLDLNHLPS APSAATAAAN NQPHQHQQLW
110 120 130 140 150
FAAPPPVPPS SDHHHQHHRI FLRTGVLNDK TSDYSSTEAP LYFTSSPNTA
160 170 180
TSSPGYQVVG FPMMNSSPSP VTVRRGLAID LNEPPPLWL
Length:189
Mass (Da):20,947
Last modified:December 1, 2001 - v1
Checksum:iFC58B8B7F656F0FF
GO

Sequence cautioni

The sequence AAF16760.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055883 Genomic DNA. Translation: BAB62912.1.
AC010155 Genomic DNA. Translation: AAF16760.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30962.1.
AY099798 mRNA. Translation: AAM20649.1.
BT002604 mRNA. Translation: AAO00964.1.
RefSeqiNP_174158.1. NM_102602.5.
UniGeneiAt.40906.

Genome annotation databases

EnsemblPlantsiAT1G28360.1; AT1G28360.1; AT1G28360.
GeneIDi839732.
GrameneiAT1G28360.1; AT1G28360.1; AT1G28360.
KEGGiath:AT1G28360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055883 Genomic DNA. Translation: BAB62912.1.
AC010155 Genomic DNA. Translation: AAF16760.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30962.1.
AY099798 mRNA. Translation: AAM20649.1.
BT002604 mRNA. Translation: AAO00964.1.
RefSeqiNP_174158.1. NM_102602.5.
UniGeneiAt.40906.

3D structure databases

ProteinModelPortaliQ94ID6.
SMRiQ94ID6. Positions 11-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24967. 13 interactions.
IntActiQ94ID6. 11 interactions.
STRINGi3702.AT1G28360.1.

Proteomic databases

PaxDbiQ94ID6.
PRIDEiQ94ID6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G28360.1; AT1G28360.1; AT1G28360.
GeneIDi839732.
GrameneiAT1G28360.1; AT1G28360.1; AT1G28360.
KEGGiath:AT1G28360.

Organism-specific databases

TAIRiAT1G28360.

Phylogenomic databases

eggNOGiENOG410IZFN. Eukaryota.
ENOG41123N5. LUCA.
HOGENOMiHOG000237624.
InParanoidiQ94ID6.
OMAiMASTTCA.
PhylomeDBiQ94ID6.

Miscellaneous databases

PROiQ94ID6.

Gene expression databases

GenevisibleiQ94ID6. AT.

Family and domain databases

Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Repression domains of class II ERF transcriptional repressors share an essential motif for active repression."
    Ohta M., Matsui K., Hiratsu K., Shinshi H., Ohme-Takagi M.
    Plant Cell 13:1959-1968(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DOMAIN.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide analysis of the ERF gene family in Arabidopsis and rice."
    Nakano T., Suzuki K., Fujimura T., Shinshi H.
    Plant Physiol. 140:411-432(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiERF81_ARATH
AccessioniPrimary (citable) accession number: Q94ID6
Secondary accession number(s): Q9SGN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: February 17, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.