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Protein

Ethylene-responsive transcription factor 12

Gene

ERF12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi11 – 68AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processEthylene signaling pathway, Plant defense, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor 12
Short name:
AtERF12
Alternative name(s):
Ethylene-responsive element-binding factor 12
Short name:
EREBP-12
Gene namesi
Name:ERF12
Synonyms:ERF-12, ERF081
Ordered Locus Names:At1g28360
ORF Names:F3M18.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G28360
TAIRilocus:2032510 AT1G28360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125621 – 189Ethylene-responsive transcription factor 12Add BLAST189

Proteomic databases

PaxDbiQ94ID6

Expressioni

Gene expression databases

ExpressionAtlasiQ94ID6 baseline and differential
GenevisibleiQ94ID6 AT

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi24967, 13 interactors
IntActiQ94ID6, 21 interactors
STRINGi3702.AT1G28360.1

Structurei

3D structure databases

ProteinModelPortaliQ94ID6
SMRiQ94ID6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 185EAR-like (transcriptional repression)7

Domaini

Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZFN Eukaryota
ENOG41123N5 LUCA
HOGENOMiHOG000237624
InParanoidiQ94ID6
OMAiEAPLYFT
OrthoDBiEOG09360W5H
PhylomeDBiQ94ID6

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequencei

Sequence statusi: Complete.

Q94ID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTCAREV HYRGVRKRPW GRYAAEIRDP WKKTRVWLGT FDTPEEAALA
60 70 80 90 100
YDGAARFLRG IKAKTNFPSP LSLDLNHLPS APSAATAAAN NQPHQHQQLW
110 120 130 140 150
FAAPPPVPPS SDHHHQHHRI FLRTGVLNDK TSDYSSTEAP LYFTSSPNTA
160 170 180
TSSPGYQVVG FPMMNSSPSP VTVRRGLAID LNEPPPLWL
Length:189
Mass (Da):20,947
Last modified:December 1, 2001 - v1
Checksum:iFC58B8B7F656F0FF
GO

Sequence cautioni

The sequence AAF16760 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055883 Genomic DNA Translation: BAB62912.1
AC010155 Genomic DNA Translation: AAF16760.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30962.1
AY099798 mRNA Translation: AAM20649.1
BT002604 mRNA Translation: AAO00964.1
RefSeqiNP_174158.1, NM_102602.6
UniGeneiAt.40906

Genome annotation databases

EnsemblPlantsiAT1G28360.1; AT1G28360.1; AT1G28360
GeneIDi839732
GrameneiAT1G28360.1; AT1G28360.1; AT1G28360
KEGGiath:AT1G28360

Similar proteinsi

Entry informationi

Entry nameiERF81_ARATH
AccessioniPrimary (citable) accession number: Q94ID6
Secondary accession number(s): Q9SGN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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