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Protein

ABC transporter D family member 1

Gene

ABCC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the transport of fatty acids and their derivatives (acyl CoAs) across the peroxisomal membrane. Provides acetate to the glyoxylate cycle in developing seedlings. Involved in pollen tube elongation, ovule fertilization, and seeds germination after imbibition (controls the switch between the opposing developmental programs of dormancy and germination), probably by promoting beta-oxidation of storage lipids during gluconeogenesis. Required for biosynthesis of jasmonic acid and conversion of indole butyric acid to indole acetic acid. Confers sensitivity to monofluoroacetic acid (FAc), a toxic acetate analog, and to 2,4-dichlorophenoxybutyric acid (2,4-DB) and indole-3-butyric acid (IBA), two precursors of auxin after beta-oxidation.11 Publications

Catalytic activityi

ATP + H2O + fatty acyl CoA(Cis) = ADP + phosphate + fatty acyl CoA(Trans).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi481 – 488ATPPROSITE-ProRule annotation8
Nucleotide bindingi1130 – 1137ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • lipid catabolic process Source: CACAO

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G39850-MONOMER.
BRENDAi3.6.3.47. 399.
ReactomeiR-ATH-1369062. ABC transporters in lipid homeostasis.
R-ATH-2046105. Linoleic acid (LA) metabolism.
R-ATH-2046106. alpha-linolenic acid (ALA) metabolism.
R-ATH-390247. Beta-oxidation of very long chain fatty acids.

Protein family/group databases

TCDBi3.A.1.203.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter D family member 1 (EC:3.6.3.47)
Short name:
ABC transporter ABCD.1
Short name:
AtABCD1
Alternative name(s):
Peroxisomal ABC transporter 1
Short name:
AtPXA1
Protein ACETATE NON-UTILIZING 2
Protein COMATOSE
Protein PEROXISOME DEFECTIVE 3
Short name:
Ped3p
Gene namesi
Name:ABCC1
Synonyms:ACN2, CTS, PED3, PMP2, PXA1
Ordered Locus Names:At4g39850
ORF Names:T5J17.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G39850.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei247 – 267HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei342 – 362HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei900 – 920HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Glyoxysome, Membrane, Peroxisome

Pathology & Biotechi

Disruption phenotypei

Impaired germination after imbibition, rescued by sucrose treatment. Resistance to FAc, IBA and 2,4-DB. Compromised ability to convert acetate into soluble carbohydrate. Defective in lipid mobilization and accumulate acyl CoAs. Poor initiation of lateral root formation and smaller rosettes with fewer leaves than in wild-type. Crinkled and waxy leaves.10 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi810S → N in ped3-4; Normal germination, but impaired seedling, roots and leaves growth. 1 Publication1
Mutagenesisi1035R → W in ped3-2; Normal germination, but impaired seedling, roots and leaves growth. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003791351 – 1337ABC transporter D family member 1Add BLAST1337

Proteomic databases

PaxDbiQ94FB9.

PTM databases

iPTMnetiQ94FB9.

Expressioni

Developmental stagei

Levels increase transiently after germination, before and during radicle emergence, especially in darkness (at protein level).2 Publications

Gene expression databases

ExpressionAtlasiQ94FB9. baseline and differential.
GenevisibleiQ94FB9. AT.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi15424. 7 interactors.
IntActiQ94FB9. 2 interactors.
MINTiMINT-8381987.
STRINGi3702.AT4G39850.3.

Structurei

3D structure databases

ProteinModelPortaliQ94FB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 395ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini448 – 695ABC transporter 1PROSITE-ProRule annotationAdd BLAST248
Domaini751 – 1049ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST299
Domaini1091 – 1337ABC transporter 2PROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0060. Eukaryota.
KOG0064. Eukaryota.
COG4178. LUCA.
HOGENOMiHOG000030359.
PhylomeDBiQ94FB9.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF06472. ABC_membrane_2. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q94FB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLQLLQLT ERGRGLVASR RKSILLAAGI VAAGGTAVYL KSRVASRRPD
60 70 80 90 100
SSRLCNGQSD DDETLEKLTA TDQNAKITTK KKKGGGLKSL QVLTAILLSQ
110 120 130 140 150
MGKMGARDLL ALVATVVFRT ALSNRLAKVQ GFLFRAAFLR RAPLFLRLIS
160 170 180 190 200
ENIMLCFMLS TLHSTSKYIT GALSLRFRKI LTKIIHSHYF ENMVYYKISH
210 220 230 240 250
VDGRITHPEQ RIASDVPRFS SELSDLILDD LTAVTDGILY AWRLCSYASP
260 270 280 290 300
KYIFWILAYV LGAGTAIRNF SPSFGKLMSK EQQLEGEYRQ LHSRLRTHSE
310 320 330 340 350
SIAFYGGETR EESHIQQKFK NLVSHMSHVL HDHWWFGMIQ DFLLKYLGAT
360 370 380 390 400
VAVILIIEPF FSGHLRPDDS TLGRAEMLSN IRYHTSVIIS LFQALGTLSI
410 420 430 440 450
SSRRLNRLSG YADRIHELMA VSRELSGDDK SSFQRNRSRN YLSEANYVEF
460 470 480 490 500
SDVKVVTPTG NVLVEDLTLR VEQGSNLLIT GPNGSGKSSL FRVLGGLWPL
510 520 530 540 550
VSGHIVKPGV GSDLNKEIFY VPQRPYMAVG TLRDQLIYPL TSGQESELLT
560 570 580 590 600
EIGMVELLKN VDLEYLLDRY QPEKEVNWGD ELSLGEQQRL GMARLFYHKP
610 620 630 640 650
KFAILDECTS AVTTDMEERF AAKVRAMGTS CITISHRPAL VAFHDVVLSL
660 670 680 690 700
DGEGGWSVHY KRDDSALLTD AEIDSVKSSD TDRQNDAMVV QRAFAAARKE
710 720 730 740 750
SATNSKAQSY QTQLIARSPV VDKSVVLPRF PQPQTSQRAL PSRVAAMLNV
760 770 780 790 800
LIPTIFDKQG AQLLAVACLV VSRTLISDRI ASLNGTTVKY VLEQDKAAFV
810 820 830 840 850
RLIGLSVLQS GASSIIAPSL RHLTQRLALG WRIRLTQHLL RNYLRNNAFY
860 870 880 890 900
KVFHMSGNSI DADQRLTRDL EKLTADLSGL LTGMVKPSVD ILWFTWRMKL
910 920 930 940 950
LTGQRGVAIL YTYMLLGLGF LRRVAPDFGD LAGEEQQLEG KFRFMHERLN
960 970 980 990 1000
THAESIAFFG GGAREKAMVD KKFRALLDHS LMLLRKKWLY GILDDFVTKQ
1010 1020 1030 1040 1050
LPNNVTWGLS LLYALEHKGD RALVSTQGEL AHALRYLASV VSQSFMAFGD
1060 1070 1080 1090 1100
ILELHKKFLE LSGGINRIFE LDEFLDASQS GVTSENQTSR LDSQDLLSFS
1110 1120 1130 1140 1150
EVDIITPAQK LMASKLSCEI VSGKSLLVTG PNGSGKTSVF RVLRDIWPTV
1160 1170 1180 1190 1200
CGRLTKPSLD IKELGSGNGM FFVPQRPYTC LGTLRDQIIY PLSKEEAEKR
1210 1220 1230 1240 1250
AAKLYTSGES STEAGSILDS HLKTILENVR LVYLLERDVG GWDATTNWED
1260 1270 1280 1290 1300
ILSLGEQQRL GMARLFFHRP KFGVLDECTN ATSVDVEEQL YRVARDMGVT
1310 1320 1330
FITSSQRPAL IPFHSLELRL IDGEGNWELR SIEQTTE
Length:1,337
Mass (Da):149,576
Last modified:December 1, 2001 - v1
Checksum:i9AA08CF944FC8BFE
GO

Sequence cautioni

The sequence CAB38898 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80648 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64T → A in BAB84551 (PubMed:11828016).Curated1
Sequence conflicti64T → A in BAB84550 (PubMed:11828016).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378120 mRNA. Translation: AAK95343.1.
AJ311341 Genomic DNA. Translation: CAC85290.1.
AB070615 Genomic DNA. Translation: BAB84550.1.
AB070616 mRNA. Translation: BAB84551.1.
AL035708 Genomic DNA. Translation: CAB38898.1. Sequence problems.
AL161596 Genomic DNA. Translation: CAB80648.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE87126.1.
CP002687 Genomic DNA. Translation: ANM66328.1.
PIRiT06091.
RefSeqiNP_001328232.1. NM_001342558.1. [Q94FB9-1]
NP_568072.1. NM_120148.3. [Q94FB9-1]
UniGeneiAt.22795.

Genome annotation databases

EnsemblPlantsiAT4G39850.1; AT4G39850.1; AT4G39850. [Q94FB9-1]
AT4G39850.4; AT4G39850.4; AT4G39850. [Q94FB9-1]
GeneIDi830144.
GrameneiAT4G39850.1; AT4G39850.1; AT4G39850.
AT4G39850.4; AT4G39850.4; AT4G39850.
KEGGiath:AT4G39850.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAB1D_ARATH
AccessioniPrimary (citable) accession number: Q94FB9
Secondary accession number(s): Q8VWH7, Q9SMR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families