Reviewed,
UniProtKB/Swiss-Prot Q94EJ2 (HDA8_ARATH)
Last modified
November 3, 2009.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Histone deacetylase 8 EC=3.5.1.98 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 377 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the histone deacetylase family. |
| Sequence caution | The sequence AAF22892.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Molecular function | Chromatin regulator Hydrolase Repressor |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcriptionInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| AF510167 mRNA. Translation: AAM49769.1. AC006932 Genomic DNA. Translation: AAF22892.1. Sequence problems. AF410272 mRNA. Translation: AAK95258.1. AF428369 mRNA. Translation: AAL16299.1. Different initiation. AY097371 mRNA. Translation: AAM19887.1. | |
| IPI | IPI00548930. |
| PIR | G86217. |
| RefSeq | NP_563817.1. |
| UniGene | At.26246 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1C3P based on UniProtKB O67135. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q94EJ2. |
Genome annotation databases | |
| GeneID | 837366. |
| GenomeReviews | Gene locus AT1G08460 in contig CT485782_GR. |
| KEGG | ath:AT1G08460. |
| NMPDR | fig|3702.1.peg.1054. |
Organism-specific databases | |
| TAIR | At1g08460. |
Phylogenomic databases | |
| OMA | GRRTTEN. |
Gene expression databases | |
| Genevestigator | Q94EJ2. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. [Graphical view] |
| Gene3D | G3DSA:3.40.800.20. His_deacetylse. 1 hit. |
| PANTHER | PTHR10625. His_deacetylse. 1 hit. |
| Pfam | PF00850. Hist_deacetyl. 1 hit. [Graphical view] |
| PRINTS | PR01270. HDASUPER. |
| ProtoNet | Search... |
Entry information
| Entry name | HDA8_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q94EJ2 Secondary accession number(s): Q944J5, Q9SJE6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


