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Q94EJ2

- HDA8_ARATH

UniProt

Q94EJ2 - HDA8_ARATH

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Protein

Histone deacetylase 8

Gene

HDA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciARA:AT1G08460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Gene namesi
Name:HDA8
Ordered Locus Names:At1g08460
ORF Names:T27G7.14, T27G7_7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G08460.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Histone deacetylase 8PRO_0000280087Add
BLAST

Proteomic databases

PaxDbiQ94EJ2.
PRIDEiQ94EJ2.

Expressioni

Gene expression databases

GenevestigatoriQ94EJ2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G08460.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ94EJ2.
SMRiQ94EJ2. Positions 39-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 336332Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225183.
InParanoidiQ94EJ2.
OMAiFISTHQM.
PhylomeDBiQ94EJ2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q94EJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTNRVDVFW HEGMLRHDAV EGVFDTGYDP GFLDVLEKHP ENADRVRNML
60 70 80 90 100
SILRRGPIAP HVNWFTGLPA IVSELLMFHT SEYIEKLVEA DKSGERCEIA
110 120 130 140 150
AGTFMSPGSW EAALLAAGTT LSAMQHILDC HGKIAYALVR PPGHHSQPTQ
160 170 180 190 200
ADGYCFLNNA ALAVKLALNS GSCSRVAVID IDVHYGNGTA EGFYTSDKVL
210 220 230 240 250
TVSLHMNHGS WGSSHPQKGS IDELGEDVGL GYNLNVPLPN GTGDRGYEYA
260 270 280 290 300
MNELVVPAVR RFGPDMVVLV VGQDSSAFDP NGRQSLTMNG YRRIGQIMRG
310 320 330 340 350
VAEEHSHGRL LMVQEGGYHV TYAAYCLHAM LEGVLKIPEP HLSDPIAYYP
360 370
EEEANAVAAV ESIKTYHTEF VPFLRGT
Length:377
Mass (Da):41,263
Last modified:December 1, 2001 - v1
Checksum:i538E741343EC8CF3
GO

Sequence cautioni

The sequence AAL16299.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF22892.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510167 mRNA. Translation: AAM49769.1.
AC006932 Genomic DNA. Translation: AAF22892.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28294.1.
AF410272 mRNA. Translation: AAK95258.1.
AF428369 mRNA. Translation: AAL16299.1. Different initiation.
AY097371 mRNA. Translation: AAM19887.1.
PIRiG86217.
RefSeqiNP_563817.1. NM_100719.3.
UniGeneiAt.26246.

Genome annotation databases

EnsemblPlantsiAT1G08460.1; AT1G08460.1; AT1G08460.
GeneIDi837366.
KEGGiath:AT1G08460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510167 mRNA. Translation: AAM49769.1 .
AC006932 Genomic DNA. Translation: AAF22892.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28294.1 .
AF410272 mRNA. Translation: AAK95258.1 .
AF428369 mRNA. Translation: AAL16299.1 . Different initiation.
AY097371 mRNA. Translation: AAM19887.1 .
PIRi G86217.
RefSeqi NP_563817.1. NM_100719.3.
UniGenei At.26246.

3D structure databases

ProteinModelPortali Q94EJ2.
SMRi Q94EJ2. Positions 39-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G08460.1-P.

Proteomic databases

PaxDbi Q94EJ2.
PRIDEi Q94EJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G08460.1 ; AT1G08460.1 ; AT1G08460 .
GeneIDi 837366.
KEGGi ath:AT1G08460.

Organism-specific databases

TAIRi AT1G08460.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225183.
InParanoidi Q94EJ2.
OMAi FISTHQM.
PhylomeDBi Q94EJ2.

Enzyme and pathway databases

BioCyci ARA:AT1G08460-MONOMER.

Gene expression databases

Genevestigatori Q94EJ2.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiHDA8_ARATH
AccessioniPrimary (citable) accession number: Q94EJ2
Secondary accession number(s): Q944J5, Q9SJE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3