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Protein

Histone deacetylase 8

Gene

HDA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145Proton donor/acceptorBy similarity1
Metal bindingi182ZincBy similarity1
Metal bindingi184Zinc; via pros nitrogenBy similarity1
Metal bindingi274ZincBy similarity1
Sitei318Polarizes the scissile carbonyl of the substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Gene namesi
Name:HDA8
Ordered Locus Names:At1g08460
ORF Names:T27G7.14, T27G7_7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT1G08460
TAIRilocus:2201826 AT1G08460

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800871 – 377Histone deacetylase 8Add BLAST377

Proteomic databases

PaxDbiQ94EJ2

Expressioni

Gene expression databases

ExpressionAtlasiQ94EJ2 baseline and differential
GenevisibleiQ94EJ2 AT

Interactioni

Protein-protein interaction databases

BioGridi22607, 1 interactor
STRINGi3702.AT1G08460.1

Structurei

3D structure databases

ProteinModelPortaliQ94EJ2
SMRiQ94EJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 336Histone deacetylaseAdd BLAST332

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225183
InParanoidiQ94EJ2
OMAiFCLFSNA
OrthoDBiEOG09360B88
PhylomeDBiQ94EJ2

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q94EJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTNRVDVFW HEGMLRHDAV EGVFDTGYDP GFLDVLEKHP ENADRVRNML
60 70 80 90 100
SILRRGPIAP HVNWFTGLPA IVSELLMFHT SEYIEKLVEA DKSGERCEIA
110 120 130 140 150
AGTFMSPGSW EAALLAAGTT LSAMQHILDC HGKIAYALVR PPGHHSQPTQ
160 170 180 190 200
ADGYCFLNNA ALAVKLALNS GSCSRVAVID IDVHYGNGTA EGFYTSDKVL
210 220 230 240 250
TVSLHMNHGS WGSSHPQKGS IDELGEDVGL GYNLNVPLPN GTGDRGYEYA
260 270 280 290 300
MNELVVPAVR RFGPDMVVLV VGQDSSAFDP NGRQSLTMNG YRRIGQIMRG
310 320 330 340 350
VAEEHSHGRL LMVQEGGYHV TYAAYCLHAM LEGVLKIPEP HLSDPIAYYP
360 370
EEEANAVAAV ESIKTYHTEF VPFLRGT
Length:377
Mass (Da):41,263
Last modified:December 1, 2001 - v1
Checksum:i538E741343EC8CF3
GO

Sequence cautioni

The sequence AAF22892 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL16299 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510167 mRNA Translation: AAM49769.1
AC006932 Genomic DNA Translation: AAF22892.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28294.1
AF410272 mRNA Translation: AAK95258.1
AF428369 mRNA Translation: AAL16299.1 Different initiation.
AY097371 mRNA Translation: AAM19887.1
PIRiG86217
RefSeqiNP_563817.1, NM_100719.4
UniGeneiAt.26246

Genome annotation databases

EnsemblPlantsiAT1G08460.1; AT1G08460.1; AT1G08460
GeneIDi837366
GrameneiAT1G08460.1; AT1G08460.1; AT1G08460
KEGGiath:AT1G08460

Similar proteinsi

Entry informationi

Entry nameiHDA8_ARATH
AccessioniPrimary (citable) accession number: Q94EJ2
Secondary accession number(s): Q944J5, Q9SJE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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