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Q94CL8

- P2C48_ARATH

UniProt

Q94CL8 - P2C48_ARATH

Protein

Probable protein phosphatase 2C 48

Gene

PP2C6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Manganese 1By similarity
    Metal bindingi89 – 891Manganese 2By similarity
    Metal bindingi90 – 901Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi290 – 2901Manganese 2By similarity
    Metal bindingi349 – 3491Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G55050-MONOMER.
    ARA:GQT-2379-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 48 (EC:3.1.3.16)
    Short name:
    AtPP2C48
    Alternative name(s):
    Protein phosphatase 2C 6
    Gene namesi
    Name:PP2C6
    Ordered Locus Names:At3g55050
    ORF Names:T15C9.50
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G55050.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Probable protein phosphatase 2C 48PRO_0000367972Add
    BLAST

    Proteomic databases

    PRIDEiQ94CL8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ94CL8.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G55050.2-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ94CL8.
    SMRiQ94CL8. Positions 84-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 330247PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000238703.
    InParanoidiQ94CL8.
    OMAiFRRIVSP.
    PhylomeDBiQ94CL8.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q94CL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSTTFRRIV SPCWRPFGIG EDSSPGSDDT NGRLDGLLWY KDSGNHITGE    50
    FSMAVVQANN LLEDHSQLES GPISLHESGP EATFVGVYDG HGGPEAARFV 100
    NDRLFYNIKR YTSEQRGMSP DVITRGFVAT EEEFLGLVQE QWKTKPQIAS 150
    VGACCLVGIV CNGLLYVANA GDSRVVLGKV ANPFKELKAV QLSTEHNASI 200
    ESVREELRLL HPDDPNIVVL KHKVWRVKGI IQVSRSIGDA YLKRAEFNQE 250
    PLLPKFRVPE RFEKPIMRAE PTITVHKIHP EDQFLIFASD GLWEHLSNQE 300
    AVDIVNSCPR NGVARKLVKA ALQEAAKKRE MRYSDLEKIE RGIRRHFHDD 350
    ITVIVVFLHA TNFATRTPIS VKGGGLLSAH NPVL 384
    Length:384
    Mass (Da):42,851
    Last modified:December 1, 2001 - v1
    Checksum:i26015C8E6737AE3A
    GO

    Sequence cautioni

    The sequence CAB82700.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302053 Genomic DNA. Translation: CAC44619.1.
    AL132970 Genomic DNA. Translation: CAB82700.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE79332.1.
    CP002686 Genomic DNA. Translation: AEE79333.1.
    BT014892 mRNA. Translation: AAT44968.1.
    BT021925 mRNA. Translation: AAX49374.1.
    AK229292 mRNA. Translation: BAF01155.1.
    PIRiT47644.
    RefSeqiNP_191065.2. NM_115363.3.
    NP_974438.1. NM_202709.1.
    UniGeneiAt.28200.

    Genome annotation databases

    EnsemblPlantsiAT3G55050.1; AT3G55050.1; AT3G55050.
    AT3G55050.2; AT3G55050.2; AT3G55050.
    GeneIDi824671.
    KEGGiath:AT3G55050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302053 Genomic DNA. Translation: CAC44619.1 .
    AL132970 Genomic DNA. Translation: CAB82700.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE79332.1 .
    CP002686 Genomic DNA. Translation: AEE79333.1 .
    BT014892 mRNA. Translation: AAT44968.1 .
    BT021925 mRNA. Translation: AAX49374.1 .
    AK229292 mRNA. Translation: BAF01155.1 .
    PIRi T47644.
    RefSeqi NP_191065.2. NM_115363.3.
    NP_974438.1. NM_202709.1.
    UniGenei At.28200.

    3D structure databases

    ProteinModelPortali Q94CL8.
    SMRi Q94CL8. Positions 84-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G55050.2-P.

    Proteomic databases

    PRIDEi Q94CL8.

    Protocols and materials databases

    DNASUi 824671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G55050.1 ; AT3G55050.1 ; AT3G55050 .
    AT3G55050.2 ; AT3G55050.2 ; AT3G55050 .
    GeneIDi 824671.
    KEGGi ath:AT3G55050.

    Organism-specific databases

    TAIRi AT3G55050.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000238703.
    InParanoidi Q94CL8.
    OMAi FRRIVSP.
    PhylomeDBi Q94CL8.

    Enzyme and pathway databases

    BioCyci ARA:AT3G55050-MONOMER.
    ARA:GQT-2379-MONOMER.

    Gene expression databases

    Genevestigatori Q94CL8.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PP2C6, a new member of the PP2C family in Arabidopsis thaliana."
      Bargues M., Terol J., Paricio N., Perez-Alonso M.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C48_ARATH
    AccessioniPrimary (citable) accession number: Q94CL8
    Secondary accession number(s): Q9M2W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3