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Protein

Protein PHOSPHATE STARVATION RESPONSE 1

Gene

PHR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568).12 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi253 – 278H-T-H motifPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cellular response to high light intensity Source: TAIR
  • cellular response to phosphate starvation Source: TAIR
  • circadian rhythm Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • sulfate ion homeostasis Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PHOSPHATE STARVATION RESPONSE 11 Publication
Short name:
AtPHR11 Publication
Gene namesi
Name:PHR11 Publication
Ordered Locus Names:At4g28610Imported
ORF Names:T5F17.60Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G28610
TAIRilocus:2139865 AT4G28610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Strongly reduced shoot growth, and slightly increased root growth. Reduced expression of phosphate starvation-induced (PSI) genes, decreased cellular inorganic phosphate (Pi) content and shoot-to-root ratio, and impaired anthocyanin accumulation (PubMed:17927693).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004367131 – 409Protein PHOSPHATE STARVATION RESPONSE 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei399PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated by SIZ1. Sumoylation controls phosphate deficiency responses.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ94CL7

PTM databases

iPTMnetiQ94CL7

Expressioni

Inductioni

Only moderately up-regulated by Pi starvation.1 Publication

Gene expression databases

ExpressionAtlasiQ94CL7 baseline and differential

Interactioni

Subunit structurei

Homodimers and heterodimers (PubMed:20838596, PubMed:11511543). Interacts with SPX1 in a Pi-dependent manner (PubMed:25271326). Does not interact with PHL2 or PHL3 (PubMed:26586833).3 Publications

Protein-protein interaction databases

STRINGi3702.AT4G28610.1

Structurei

3D structure databases

ProteinModelPortaliQ94CL7
SMRiQ94CL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 282HTH myb-typePROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili314 – 334Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi327 – 332LHEQLECurated6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 71Poly-SerSequence analysis5

Sequence similaritiesi

Belongs to the MYB-CC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEM5 Eukaryota
ENOG410YG61 LUCA
HOGENOMiHOG000064669
OMAiEETRKCE
OrthoDBiEOG09360EUY
PhylomeDBiQ94CL7

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR025756 Myb_CC_LHEQLE
IPR017930 Myb_dom
IPR006447 Myb_dom_plants
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF14379 Myb_CC_LHEQLE, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
TIGRFAMsiTIGR01557 myb_SHAQKYF, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit

Sequencei

Sequence statusi: Complete.

Q94CL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARPVHRSG SRDLTRTSSI PSTQKPSPVE DSFMRSDNNS QLMSRPLGQT
60 70 80 90 100
YHLLSSSNGG AVGHICSSSS SGFATNLHYS TMVSHEKQQH YTGSSSNNAV
110 120 130 140 150
QTPSNNDSAW CHDSLPGGFL DFHETNPAIQ NNCQIEDGGI AAAFDDIQKR
160 170 180 190 200
SDWHEWADHL ITDDDPLMST NWNDLLLETN SNSDSKDQKT LQIPQPQIVQ
210 220 230 240 250
QQPSPSVELR PVSTTSSNSN NGTGKARMRW TPELHEAFVE AVNSLGGSER
260 270 280 290 300
ATPKGVLKIM KVEGLTIYHV KSHLQKYRTA RYRPEPSETG SPERKLTPLE
310 320 330 340 350
HITSLDLKGG IGITEALRLQ MEVQKQLHEQ LEIQRNLQLR IEEQGKYLQM
360 370 380 390 400
MFEKQNSGLT KGTASTSDSA AKSEQEDKKT ADSKEVPEEE TRKCEELESP

QPKRPKIDN
Length:409
Mass (Da):45,546
Last modified:December 1, 2001 - v1
Checksum:i2C59836D75FE33C3
GO

Sequence cautioni

The sequence CAB81449 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310799 mRNA Translation: CAC59689.1
AL161573 Genomic DNA Translation: CAB81449.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85512.1
AY081290 mRNA Translation: AAL91179.1
BT002187 mRNA Translation: AAN72198.1
PIRiT10655
RefSeqiNP_194590.2, NM_119003.4
UniGeneiAt.4525

Genome annotation databases

EnsemblPlantsiAT4G28610.1; AT4G28610.1; AT4G28610
GeneIDi828979
GrameneiAT4G28610.1; AT4G28610.1; AT4G28610
KEGGiath:AT4G28610

Similar proteinsi

Entry informationi

Entry nameiPHR1_ARATH
AccessioniPrimary (citable) accession number: Q94CL7
Secondary accession number(s): Q9M0H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health