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Q94AV5 (WIP3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WPP domain-interacting protein 3
Gene names
Name:WIP3
Ordered Locus Names:At3g13360
ORF Names:MDC11.15
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. Ref.4

Subunit structure

Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3 By similarity. Interacts with RANGAP1, WPP1/MAF1, and WPP2/MAF2. Ref.4

Subcellular location

Nucleus envelope. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side Ref.4.

Tissue specificity

Expressed in seedlings, roots, stems, leaves, and flowers. Ref.4

Developmental stage

First observed in roots and cotyledons of young developing seedlings. Later confined to root tips and cauline leaves tips. In flowers, detected in the stamens and at the senescence region of developing siliques. Ref.4

Sequence caution

The sequence BAB02805.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459WPP domain-interacting protein 3
PRO_0000347198

Regions

Transmembrane427 – 44721Helical; Potential
Coiled coil331 – 37545 Potential
Motif60 – 612Nuclear localization signal 1 By similarity
Motif63 – 642Nuclear localization signal 2 By similarity
Motif86 – 872Nuclear localization signal 3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q94AV5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6FAD2C63953AAC07

FASTA45950,274
        10         20         30         40         50         60 
MNESVPDSVE DNGNSVPANG LLVLPDNDHE EGGVGSPQRS NSVESPGGSV HSTRKGFGLK 

        70         80         90        100        110        120 
KWRRIKRDGP VRDEAAPVDD GSKLLKRGLA GLVNPPSKHV EFSSVEARQS SEGSVGSVNM 

       130        140        150        160        170        180 
VHHPGVANGF SPDIGCMFAV GQAFEKSEEH SGNTIGGKNV VGGKVVSGSQ EKLWSDTIKR 

       190        200        210        220        230        240 
ASEERGDIEK EKPCSSLDSD LRSSDFVFST GSVSVGNHGE KDERLTMNYI GGFSNEGQVK 

       250        260        270        280        290        300 
EEVQTYSRSE NGNKEDDGES KKNNNHWADK DALADSIRSF AVLQEVLWKE VQSFQELGKE 

       310        320        330        340        350        360 
SVLLHSNTDE LSSDQPSHQN CKEDNSTSSG SKALILKEKV KLLEHKLEEA RAALEAKEAR 

       370        380        390        400        410        420 
IQELENSKIE SELECIFQRK IETEIEHLML TRSLSSLQVL QETKKLHSLK EDPVSNRGNI 

       430        440        450 
LGKTCKLGFY ILTQLILLVS ILRFLVLQFS PASRLVIPT 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins."
Xu X.M., Meulia T., Meier I.
Curr. Biol. 17:1157-1163(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INTERACTION WITH RANGAP1; WPP1 AND WPP2.
[5]"Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB024034 Genomic DNA. Translation: BAB02805.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75338.1.
AY045697 mRNA. Translation: AAK74055.1.
AY149963 mRNA. Translation: AAN31117.1.
RefSeqNP_566455.1. NM_112181.4.
UniGeneAt.20916.

3D structure databases

ProteinModelPortalQ94AV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid5870. 1 interaction.
IntActQ94AV5. 4 interactions.
STRING3702.AT3G13360.1-P.

Proteomic databases

PaxDbQ94AV5.
PRIDEQ94AV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G13360.1; AT3G13360.1; AT3G13360.
GeneID820536.
KEGGath:AT3G13360.

Organism-specific databases

TAIRAT3G13360.

Phylogenomic databases

eggNOGNOG281074.
HOGENOMHOG000093093.
InParanoidQ9LTT2.
OMAFEKSEEH.
PhylomeDBQ94AV5.

Gene expression databases

GenevestigatorQ94AV5.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameWIP3_ARATH
AccessionPrimary (citable) accession number: Q94AV5
Secondary accession number(s): Q9LTT2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names