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Protein

25.3 kDa vesicle transport protein

Gene

SEC22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

V-SNARE involved in vesicle trafficking from the ER to the Golgi complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-204005 COPII (Coat Protein 2) Mediated Vesicle Transport
R-ATH-5694530 Cargo concentration in the ER
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
25.3 kDa vesicle transport protein
Short name:
AtSEC22
Gene namesi
Name:SEC22
Ordered Locus Names:At1g11890
ORF Names:F12F1.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G11890
TAIRilocus:2008960 AT1G11890

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini214 – 218VesicularSequence analysis5

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067471 – 21825.3 kDa vesicle transport proteinAdd BLAST218

Proteomic databases

PaxDbiQ94AU2
PRIDEiQ94AU2

Expressioni

Gene expression databases

ExpressionAtlasiQ94AU2 baseline and differential
GenevisibleiQ94AU2 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi22977, 10 interactors
STRINGi3702.AT1G11890.1

Structurei

3D structure databases

ProteinModelPortaliQ94AU2
SMRiQ94AU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 120LonginPROSITE-ProRule annotationAdd BLAST115
Domaini135 – 195v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
HOGENOMiHOG000044957
InParanoidiQ94AU2
KOiK08517
OMAiMLCASVD
OrthoDBiEOG09360M0G
PhylomeDBiQ94AU2

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q94AU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMTLIARV TDGLPLAEGL DDGRDLPDSD MYKQQVKALF KNLSRGQNDA
60 70 80 90 100
SRMSVETGPY VFHYIIEGRV CYLTMCDRSY PKKLAFQYLE DLKNEFERVN
110 120 130 140 150
GPNIETAARP YAFIKFDTFI QKTKKLYQDT RTQRNIAKLN DELYEVHQIM
160 170 180 190 200
TRNVQEVLGV GEKLDQVSEM SSRLTSESRI YADKAKDLNR QALIRKWAPV
210
AIVFGVVFLL FWVKNKLW
Length:218
Mass (Da):25,332
Last modified:December 1, 2001 - v1
Checksum:i3DD6401E8EC4F93D
GO

Sequence cautioni

The sequence AAC17634 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002131 Genomic DNA Translation: AAC17634.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28809.1
AY045795 mRNA Translation: AAK76469.1
AY079413 mRNA Translation: AAL85144.1
AY086749 mRNA Translation: AAM63800.1
PIRiC86253
RefSeqiNP_172653.1, NM_101060.4
UniGeneiAt.10645

Genome annotation databases

EnsemblPlantsiAT1G11890.1; AT1G11890.1; AT1G11890
GeneIDi837737
GrameneiAT1G11890.1; AT1G11890.1; AT1G11890
KEGGiath:AT1G11890

Similar proteinsi

Entry informationi

Entry nameiSEC22_ARATH
AccessioniPrimary (citable) accession number: Q94AU2
Secondary accession number(s): O65393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health