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Protein

25.3 kDa vesicle transport protein

Gene

SEC22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

V-SNARE involved in vesicle trafficking from the ER to the Golgi complex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-ATH-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
25.3 kDa vesicle transport protein
Short name:
AtSEC22
Gene namesi
Name:SEC22
Ordered Locus Names:At1g11890
ORF Names:F12F1.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G11890.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 192192CytoplasmicSequence analysisAdd
BLAST
Transmembranei193 – 21321Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini214 – 2185VesicularSequence analysis

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: TAIR
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21821825.3 kDa vesicle transport proteinPRO_0000206747Add
BLAST

Proteomic databases

PaxDbiQ94AU2.
PRIDEiQ94AU2.

Expressioni

Gene expression databases

GenevisibleiQ94AU2. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi22977. 10 interactions.
STRINGi3702.AT1G11890.1.

Structurei

3D structure databases

ProteinModelPortaliQ94AU2.
SMRiQ94AU2. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 120115LonginPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 19561v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
HOGENOMiHOG000044957.
InParanoidiQ94AU2.
KOiK08517.
OMAiVLYFWVL.
PhylomeDBiQ94AU2.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94AU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMTLIARV TDGLPLAEGL DDGRDLPDSD MYKQQVKALF KNLSRGQNDA
60 70 80 90 100
SRMSVETGPY VFHYIIEGRV CYLTMCDRSY PKKLAFQYLE DLKNEFERVN
110 120 130 140 150
GPNIETAARP YAFIKFDTFI QKTKKLYQDT RTQRNIAKLN DELYEVHQIM
160 170 180 190 200
TRNVQEVLGV GEKLDQVSEM SSRLTSESRI YADKAKDLNR QALIRKWAPV
210
AIVFGVVFLL FWVKNKLW
Length:218
Mass (Da):25,332
Last modified:December 1, 2001 - v1
Checksum:i3DD6401E8EC4F93D
GO

Sequence cautioni

The sequence AAC17634.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002131 Genomic DNA. Translation: AAC17634.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28809.1.
AY045795 mRNA. Translation: AAK76469.1.
AY079413 mRNA. Translation: AAL85144.1.
AY086749 mRNA. Translation: AAM63800.1.
PIRiC86253.
RefSeqiNP_172653.1. NM_101060.3.
UniGeneiAt.10645.

Genome annotation databases

EnsemblPlantsiAT1G11890.1; AT1G11890.1; AT1G11890.
GeneIDi837737.
GrameneiAT1G11890.1; AT1G11890.1; AT1G11890.
KEGGiath:AT1G11890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002131 Genomic DNA. Translation: AAC17634.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28809.1.
AY045795 mRNA. Translation: AAK76469.1.
AY079413 mRNA. Translation: AAL85144.1.
AY086749 mRNA. Translation: AAM63800.1.
PIRiC86253.
RefSeqiNP_172653.1. NM_101060.3.
UniGeneiAt.10645.

3D structure databases

ProteinModelPortaliQ94AU2.
SMRiQ94AU2. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22977. 10 interactions.
STRINGi3702.AT1G11890.1.

Proteomic databases

PaxDbiQ94AU2.
PRIDEiQ94AU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G11890.1; AT1G11890.1; AT1G11890.
GeneIDi837737.
GrameneiAT1G11890.1; AT1G11890.1; AT1G11890.
KEGGiath:AT1G11890.

Organism-specific databases

TAIRiAT1G11890.

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
HOGENOMiHOG000044957.
InParanoidiQ94AU2.
KOiK08517.
OMAiVLYFWVL.
PhylomeDBiQ94AU2.

Enzyme and pathway databases

ReactomeiR-ATH-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-ATH-5694530. Cargo concentration in the ER.

Miscellaneous databases

PROiQ94AU2.

Gene expression databases

GenevisibleiQ94AU2. AT.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSEC22_ARATH
AccessioniPrimary (citable) accession number: Q94AU2
Secondary accession number(s): O65393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.