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Q94AT1

- P2C76_ARATH

UniProt

Q94AT1 - P2C76_ARATH

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Protein

Probable protein phosphatase 2C 76

Gene

At5g53140

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi137 – 1371Manganese 1By similarity
Metal bindingi137 – 1371Manganese 2By similarity
Metal bindingi138 – 1381Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi299 – 2991Manganese 2By similarity
Metal bindingi338 – 3381Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G53140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 76 (EC:3.1.3.16)
Short name:
AtPP2C76
Gene namesi
Ordered Locus Names:At5g53140
ORF Names:MFH8.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G53140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Probable protein phosphatase 2C 76PRO_0000367996Add
BLAST

Proteomic databases

PaxDbiQ94AT1.
PRIDEiQ94AT1.

Expressioni

Gene expression databases

GenevestigatoriQ94AT1.

Interactioni

Protein-protein interaction databases

BioGridi20640. 4 interactions.
IntActiQ94AT1. 1 interaction.
MINTiMINT-8390589.
STRINGi3702.AT5G53140.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ94AT1.
SMRiQ94AT1. Positions 100-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 340241PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ94AT1.
KOiK17506.
OMAiETYKQTD.
PhylomeDBiQ94AT1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94AT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCSSFIRSF IVQAGCRIGV LAQGRHQFIH IKKTLSVGFG FRTSVIGFRT
60 70 80 90 100
TSGIGFRTSA KMMVDTSAGE KRISLVDMPP EKVDDGGYIG GGWKNDDGSL
110 120 130 140 150
SCGYCSFRGK RSTMEDFYDI KASTIEGQAV CMFGIFDGHG GSRAAEYLKE
160 170 180 190 200
HLFNNLMKHP QFLTDTKLAL NETYKQTDVA FLESEKDTYR DDGSTASAAV
210 220 230 240 250
LVGNHLYVAN VGDSRTIVSK AGKAIALSDD HKPNRSDERK RIESAGGVIM
260 270 280 290 300
WAGTWRVGGV LAMSRAFGNR MLKQFVVAEP EIQDLEIDHE AELLVLASDG
310 320 330 340 350
LWDVVPNEDA VALAQSEEEP EAAARKLTDT AFSRGSADNI TCIVVKFRHD
360 370 380 390 400
KTESPKIETN AMAESEPELN PTTELEPESN PSTALETESI PKAELESEPD
410 420
AIPDPKPETE PETKGEKAGE
Length:420
Mass (Da):45,786
Last modified:December 1, 2001 - v1
Checksum:iC312D84D35159052
GO

Sequence cautioni

The sequence BAB08417.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671F → L in AAM91486. (PubMed:14593172)Curated
Sequence conflicti267 – 2671F → L in AAL57666. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025622 Genomic DNA. Translation: BAB08417.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED96312.1.
AY045819 mRNA. Translation: AAK76493.1.
AY065026 mRNA. Translation: AAL57666.1.
AY091360 mRNA. Translation: AAM14299.1.
AY133656 mRNA. Translation: AAM91486.1.
RefSeqiNP_568786.1. NM_124693.3.
UniGeneiAt.47617.

Genome annotation databases

EnsemblPlantsiAT5G53140.1; AT5G53140.1; AT5G53140.
GeneIDi835395.
KEGGiath:AT5G53140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025622 Genomic DNA. Translation: BAB08417.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED96312.1 .
AY045819 mRNA. Translation: AAK76493.1 .
AY065026 mRNA. Translation: AAL57666.1 .
AY091360 mRNA. Translation: AAM14299.1 .
AY133656 mRNA. Translation: AAM91486.1 .
RefSeqi NP_568786.1. NM_124693.3.
UniGenei At.47617.

3D structure databases

ProteinModelPortali Q94AT1.
SMRi Q94AT1. Positions 100-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 20640. 4 interactions.
IntActi Q94AT1. 1 interaction.
MINTi MINT-8390589.
STRINGi 3702.AT5G53140.1-P.

Proteomic databases

PaxDbi Q94AT1.
PRIDEi Q94AT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G53140.1 ; AT5G53140.1 ; AT5G53140 .
GeneIDi 835395.
KEGGi ath:AT5G53140.

Organism-specific databases

TAIRi AT5G53140.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q94AT1.
KOi K17506.
OMAi ETYKQTD.
PhylomeDBi Q94AT1.

Enzyme and pathway databases

BioCyci ARA:AT5G53140-MONOMER.

Gene expression databases

Genevestigatori Q94AT1.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. XI."
    Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C76_ARATH
AccessioniPrimary (citable) accession number: Q94AT1
Secondary accession number(s): Q8VZD9, Q9FGM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3