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Q94AH8

- TPS6_ARATH

UniProt

Q94AH8 - TPS6_ARATH

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6

Gene

TPS6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates plant architecture, shape of epidermal pavement cells and branching of trichomes.1 Publication

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: TAIR
  2. trehalose-phosphatase activity Source: TAIR

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. trehalose biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciARA:GQT-2365-MONOMER.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 6
Short name:
AtTPS6
Gene namesi
Name:TPS6
Ordered Locus Names:At1g68020
ORF Names:T23K23.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G68020.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi152 – 1521R → S in cps-1; loss of pavement cell lobes and altered trichomes branching. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6PRO_0000324827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ94AH8.
PRIDEiQ94AH8.

Expressioni

Tissue specificityi

Expressed in seedlings, leaves, stems, flowers, siliques and roots.1 Publication

Gene expression databases

GenevestigatoriQ94AH8.

Interactioni

Subunit structurei

Binds to the phosphopeptide-binding site of GRF/14-3-3.

Protein-protein interaction databases

BioGridi28351. 1 interaction.
STRINGi3702.AT1G68020.2-P.

Structurei

3D structure databases

ProteinModelPortaliQ94AH8.
SMRiQ94AH8. Positions 153-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 557505GlycosyltransferaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 817Poly-Ser

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191476.
InParanoidiQ94AH8.
KOiK16055.
OMAiKETAIVW.
PhylomeDBiQ94AH8.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q94AH8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRSYSNLL ELASGDSPTF GRMNRQIPRI MAVAGIMSNI DNDSKDTDLS
60 70 80 90 100
PKDRIIIVAN ELPIRAQRRV DGNGSGSSSS STCCSKGWNF SWDENSLLLQ
110 120 130 140 150
LKDGLGDEAI EVIYVGCLKE EIPLNEQEEV YQILLESFKC VPTFLPLDLY
160 170 180 190 200
TRYYHGFCKQ QLWPLFHYML PLSPDLGGRF DRTLWQAYVS VNKIFADRIM
210 220 230 240 250
EVINPEDDFV WIHDYHLMVL PTFLRKRFNR VKLGFFLHSP FPSSEIYKTL
260 270 280 290 300
PIREELLRAL LNSDLIGFHT FDYARHFLSC CSRMLGLTYE SKRGYIGLEY
310 320 330 340 350
YGRTVSIKIL PVGIHMGQLQ SVLSLPETER KVGELIERYG RKGRTMLLGV
360 370 380 390 400
DDMDIFKGIT LKLLAMEQLL MQHPEWQGKV VLVQIANPAR GKGKDVKEMQ
410 420 430 440 450
AETYSTVKRI NETFGRPGYD PIVLIDAPLK FYERVAYYVV AECCLVTAVR
460 470 480 490 500
DGMNLIPYEY IVSRQGNEKL DKILKLEANN RNKKSMLVVS EFIGCSPSLS
510 520 530 540 550
GAIRVNPWNV DAVADAMDSA LEVAEPEKQL RHEKHYKYVS THDVGYWARS
560 570 580 590 600
FLQDLERSCG EHGRRRCWGI GFGLSFRVVA LDQSFRKLSM EHIVSAYKRT
610 620 630 640 650
KTRAILLDYD DTLMPQGSID KRPSSKSIDI LNTLCRDKGN LVFIVSAKSR
660 670 680 690 700
ETLSDWFSPC EKLGIAAEHG YFLRLRKAVE WENCVAAVDC SWKQIAEPVM
710 720 730 740 750
ELYTETTDGS TIEDKETALV WSYEDADPDF GSCQAKELLD HLESVLANEP
760 770 780 790 800
VTVKRGQNYV EVKPQGVSKG LIARRMLSMM QERGTLPEFV LCIGDDRSDE
810 820 830 840 850
DMFEVICSST EGPSIAPRAE IFACTVGQKP SKAKYYLDDT TEIVRLMHGL
860
ASVTDQITPV

Note: Derived from EST data. No experimental confirmation available.

Length:860
Mass (Da):97,703
Last modified:March 18, 2008 - v2
Checksum:iA155BEB4EDAFD3A9
GO
Isoform 2 (identifier: Q94AH8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-700: LRKAVEWENCVAAVDCSWKQIAEPVM → YSTKTFYFLALPLYLITQAPSNYYTG
     701-860: Missing.

Note: No experimental confirmation available.

Show »
Length:700
Mass (Da):80,069
Checksum:iDE323A4B10FCD3FE
GO

Sequence cautioni

The sequence AAG52003.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei675 – 70026LRKAV…AEPVM → YSTKTFYFLALPLYLITQAP SNYYTG in isoform 2. CuratedVSP_032376Add
BLAST
Alternative sequencei701 – 860160Missing in isoform 2. CuratedVSP_032377Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012563 Genomic DNA. Translation: AAG52003.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34737.1.
CP002684 Genomic DNA. Translation: AEE34738.1.
AY046028 mRNA. Translation: AAK76702.1.
PIRiC96703.
RefSeqiNP_564918.1. NM_105472.3. [Q94AH8-2]
NP_974105.1. NM_202376.2. [Q94AH8-1]
UniGeneiAt.19364.

Genome annotation databases

EnsemblPlantsiAT1G68020.2; AT1G68020.2; AT1G68020. [Q94AH8-1]
GeneIDi843130.
KEGGiath:AT1G68020.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012563 Genomic DNA. Translation: AAG52003.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE34737.1 .
CP002684 Genomic DNA. Translation: AEE34738.1 .
AY046028 mRNA. Translation: AAK76702.1 .
PIRi C96703.
RefSeqi NP_564918.1. NM_105472.3. [Q94AH8-2 ]
NP_974105.1. NM_202376.2. [Q94AH8-1 ]
UniGenei At.19364.

3D structure databases

ProteinModelPortali Q94AH8.
SMRi Q94AH8. Positions 153-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 28351. 1 interaction.
STRINGi 3702.AT1G68020.2-P.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbi Q94AH8.
PRIDEi Q94AH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G68020.2 ; AT1G68020.2 ; AT1G68020 . [Q94AH8-1 ]
GeneIDi 843130.
KEGGi ath:AT1G68020.

Organism-specific databases

TAIRi AT1G68020.

Phylogenomic databases

eggNOGi COG0380.
HOGENOMi HOG000191476.
InParanoidi Q94AH8.
KOi K16055.
OMAi KETAIVW.
PhylomeDBi Q94AH8.

Enzyme and pathway databases

BioCyci ARA:GQT-2365-MONOMER.

Gene expression databases

Genevestigatori Q94AH8.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM2).
    Strain: cv. Columbia.
  4. "An unexpected plethora of trehalose biosynthesis genes in Arabidopsis thaliana."
    Leyman B., Van Dijck P., Thevelein J.M.
    Trends Plant Sci. 6:510-513(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose."
    Harthill J.E., Meek S.E.M., Morrice N., Peggie M.W., Borch J., Wong B.H.C., Mackintosh C.
    Plant J. 47:211-223(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH GRF/14-3-3, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Trehalose-6-phosphate synthase/phosphatase regulates cell shape and plant architecture in Arabidopsis."
    Chary S.N., Hicks G.R., Choi Y.G., Carter D., Raikhel N.V.
    Plant Physiol. 146:97-107(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-152.

Entry informationi

Entry nameiTPS6_ARATH
AccessioniPrimary (citable) accession number: Q94AH8
Secondary accession number(s): Q9C9W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3