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Q94AB5

- U7E12_ARATH

UniProt

Q94AB5 - U7E12_ARATH

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Protein
UDP-glycosyltransferase 76E12
Gene
UGT76E12, At3g46660, F12A12.180
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Possesses quercetin 3-O-glucosyltransferase and 7-O-glucosyltransferase activities in vitro.1 Publication

Catalytic activityi

UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.
UDP-glucose + a flavonol = UDP + a flavonol 7-O-D-glucoside.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei280 – 2801UDP-glucose By similarity

GO - Molecular functioni

  1. flavonol 3-O-glucosyltransferase activity Source: UniProtKB-EC
  2. quercetin 3-O-glucosyltransferase activity Source: TAIR
  3. quercetin 7-O-glucosyltransferase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glycosyltransferase 76E12 (EC:2.4.1.-, EC:2.4.1.91)
    Gene namesi
    Name:UGT76E12
    Ordered Locus Names:At3g46660
    ORF Names:F12A12.180
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G46660.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458UDP-glycosyltransferase 76E12
    PRO_0000409095Add
    BLAST

    Proteomic databases

    PRIDEiQ94AB5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ94AB5.
    GenevestigatoriQ94AB5.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G46660.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ94AB5.
    SMRiQ94AB5. Positions 15-452.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni339 – 3413UDP-glucose binding By similarity
    Regioni356 – 3649UDP-glucose binding By similarity
    Regioni378 – 3814UDP-glucose binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG326467.
    HOGENOMiHOG000237564.
    InParanoidiQ94AB5.
    OMAiINEIMEV.
    PhylomeDBiQ94AB5.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q94AB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVLGMEEKP ARRSVVLVPF PAQGHISPMM QLAKTLHLKG FSITVVQTKF    50
    NYFSPSDDFT HDFQFVTIPE SLPESDFKNL GPIQFLFKLN KECKVSFKDC 100
    LGQLVLQQSN EISCVIYDEF MYFAEAAAKE CKLPNIIFST TSATAFACRS 150
    VFDKLYANNV QAPLKETKGQ QEELVPEFYP LRYKDFPVSR FASLESIMEV 200
    YRNTVDKRTA SSVIINTASC LESSSLSFLQ QQQLQIPVYP IGPLHMVASA 250
    PTSLLEENKS CIEWLNKQKV NSVIYISMGS IALMEINEIM EVASGLAASN 300
    QHFLWVIRPG SIPGSEWIES MPEEFSKMVL DRGYIVKWAP QKEVLSHPAV 350
    GGFWSHCGWN STLESIGQGV PMICRPFSGD QKVNARYLEC VWKIGIQVEG 400
    ELDRGVVERA VKRLMVDEEG EEMRKRAFSL KEQLRASVKS GGSSHNSLEE 450
    FVHFIRTL 458
    Length:458
    Mass (Da):51,662
    Last modified:December 1, 2001 - v1
    Checksum:i064AC578C026B098
    GO

    Sequence cautioni

    The sequence CAB62336.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133314 Genomic DNA. Translation: CAB62336.1. Different initiation.
    CP002686 Genomic DNA. Translation: AEE78190.1.
    AY048297 mRNA. Translation: AAK82559.1.
    AY120731 mRNA. Translation: AAM53289.1.
    BT000356 mRNA. Translation: AAN15675.1.
    BT002638 mRNA. Translation: AAO11554.1.
    PIRiT45603.
    RefSeqiNP_566885.1. NM_114533.2.
    UniGeneiAt.600.

    Genome annotation databases

    EnsemblPlantsiAT3G46660.1; AT3G46660.1; AT3G46660.
    GeneIDi823819.
    KEGGiath:AT3G46660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133314 Genomic DNA. Translation: CAB62336.1 . Different initiation.
    CP002686 Genomic DNA. Translation: AEE78190.1 .
    AY048297 mRNA. Translation: AAK82559.1 .
    AY120731 mRNA. Translation: AAM53289.1 .
    BT000356 mRNA. Translation: AAN15675.1 .
    BT002638 mRNA. Translation: AAO11554.1 .
    PIRi T45603.
    RefSeqi NP_566885.1. NM_114533.2.
    UniGenei At.600.

    3D structure databases

    ProteinModelPortali Q94AB5.
    SMRi Q94AB5. Positions 15-452.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G46660.1-P.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi Q94AB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G46660.1 ; AT3G46660.1 ; AT3G46660 .
    GeneIDi 823819.
    KEGGi ath:AT3G46660.

    Organism-specific databases

    TAIRi AT3G46660.

    Phylogenomic databases

    eggNOGi NOG326467.
    HOGENOMi HOG000237564.
    InParanoidi Q94AB5.
    OMAi INEIMEV.
    PhylomeDBi Q94AB5.

    Gene expression databases

    ArrayExpressi Q94AB5.
    Genevestigatori Q94AB5.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana."
      Li Y., Baldauf S., Lim E.K., Bowles D.J.
      J. Biol. Chem. 276:4338-4343(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    5. "Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides."
      Lim E.K., Ashford D.A., Hou B., Jackson R.G., Bowles D.J.
      Biotechnol. Bioeng. 87:623-631(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiU7E12_ARATH
    AccessioniPrimary (citable) accession number: Q94AB5
    Secondary accession number(s): Q9SNB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: December 1, 2001
    Last modified: May 14, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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