Reviewed, UniProtKB/Swiss-Prot Q949M2 (FABG4_BRANA)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase 4
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase 4

Gene names

Name:

bkr4

Organism

Brassica napus (Rape)

Taxonomic identifier

3708 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Brassica

Protein attributes

Sequence length	254 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Subcellular location	Plastid › chloroplast By similarity. Plastid By similarity. Note: And non-photosynthetic plastids By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Chloroplast Plastid
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 254	›254	3-oxoacyl-[acyl-carrier-protein] reductase 4		PRO_0000054660
Regions
	Nucleotide binding	19 – 43	25	NADP By similarity
Sites
	Active site	161	1	Proton acceptor By similarity
	Binding site	148	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q949M2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F903A899E3FAB2C6	FASTA	254	26,648
	10 20 30 40 50 60 TTTEEEEAVP KVESPVVVVT GASRGIGKAI ALSLGKAGCK VLVNYARSAK EAEEVSKQIE 70 80 90 100 110 120 EYGGQAITFG GDVSKEADVD AMMKTAVDKW GTIDVVVNNA GDTLLIRMKK SQWDEVMDLN 130 140 150 160 170 180 LTGVFLCSQA ATKIMMKKRK GRIINIASVV GLIGNIGQAN YAAAKAGVIG FSKTAAREGA 190 200 210 220 230 240 SRNINVNVVC PGFIASDMTA KLGEDMEKKI LGTIPLGRYG QPEDVAGLVE FLALSPAASY 250 ITGQTFTIDG GIAI

References

[1]	McDonald F.S., White A.J., Elborough K.M., Slabas A.R. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Jet neuf. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ243086 mRNA. Translation: CAC41365.1.
3D structure databases
HSSP	HSSP built from PDB template 1EDO based on UniProtKB Q93X62.
SMR	Q949M2. Positions 14-254.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.100. 393.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG4_BRANA

Accession

Primary (citable) accession number: Q949M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)