Q94999 (GSTT2_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase 2
EC=2.5.1.18

Alternative name(s):
Aggst1-2
GST class-theta

Gene names

Name:	GstD2
Synonyms:	GST1-2
ORF Names:	AGAP004165

Organism

Anopheles gambiae (African malaria mosquito) [Reference proteome]

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Ref.1
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Theta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Glutathione S-transferase 2		PRO_0000185960
Regions
	Domain	1 – 81	81	GST N-terminal
	Domain	88 – 209	122	GST C-terminal
	Region	51 – 53	3	Glutathione binding By similarity
	Region	65 – 67	3	Glutathione binding By similarity
Sites
	Binding site	10	1	Glutathione By similarity
Experimental info
	Sequence conflict	62	1	I → V in CAA96104. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q94999 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 875B863BE805A8D3	FASTA	209	23,543
	10 20 30 40 50 60 MLDFYYLPGS APCRAVQMVA EAVHVKLNLK YLDLMAGAHR SPQFTKLNPQ RTIPTLVDGS 70 80 90 100 110 120 LILSESRAAL IYLCDQYGDE DNDWYPRDTI QRAIVNQRLF FDACVLYPRF ADFYHPQVFG 130 140 150 160 170 180 NAAPDGRKRL AFEKAVELLN IFLSEHEFVA GSKMTIADIS LFATLATACT LGFILRPYVH 190 200 VDRWYVTMVA SCPGAQANVS GAKEFLTYK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and localization of a glutathione S-transferase class I gene from Anopheles gambiae." Ranson H., Cornel A.J., Fournier D., Vaughan A., Collins F.H., Hemingway J. J. Biol. Chem. 272:5464-5468(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: Suakoko.
[2]	"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71480 Genomic DNA. Translation: CAA96104.1. AAAB01008880 Genomic DNA. Translation: EAA44715.1.
RefSeq	XP_313052.1. XM_313052.1.
3D structure databases
ProteinModelPortal	Q94999.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AGAP004165-RA; AGAP004165-PA; AGAP004165.
GeneID	1273989.
KEGG	aga:AgaP_AGAP004165.
VectorBase	AGAP004163. Anopheles gambiae.
Organism-specific databases
CTD	1273989.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125741.
InParanoid	Q94999.
OMA	RLFFDAC.
OrthoDB	EOG4CVDR4.
PhylomeDB	Q94999.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTT2_ANOGA

Accession

Primary (citable) accession number: Q94999
Secondary accession number(s): Q7PH22

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 16, 2006
Last modified:	April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)