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Protein

Voltage-dependent anion-selective channel

Gene

porin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei72Involved in hexokinase bindingBy similarity1

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: FlyBase

GO - Biological processi

  • ion transport Source: FlyBase
  • mitochondrion organization Source: FlyBase
  • photoreceptor cell maintenance Source: FlyBase
  • phototransduction Source: FlyBase
  • regulation of cilium assembly Source: InterPro
  • sperm individualization Source: FlyBase
  • sperm mitochondrion organization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-5205685. Pink/Parkin Mediated Mitophagy.

Protein family/group databases

TCDBi1.B.8.1.6. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel
Alternative name(s):
DmVDAC
Porin
Gene namesi
Name:porin
Synonyms:POR-1, VDAC
ORF Names:CG6647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004363. porin.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • mitochondrial outer membrane Source: FlyBase
  • mitochondrion Source: FlyBase
  • Nebenkern Source: FlyBase
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000505202 – 282Voltage-dependent anion-selective channelAdd BLAST281

Proteomic databases

PaxDbiQ94920.
PRIDEiQ94920.

Expressioni

Developmental stagei

Expressed throughout development, highest levels are in embryos and pupae.1 Publication

Gene expression databases

BgeeiFBgn0004363.
ExpressionAtlasiQ94920. baseline.
GenevisibleiQ94920. DM.

Interactioni

Subunit structurei

Interacts with hexokinases.By similarity

Protein-protein interaction databases

BioGridi60572. 70 interactors.
DIPiDIP-17501N.
IntActiQ94920. 5 interactors.
MINTiMINT-926159.
STRINGi7227.FBpp0079772.

Structurei

3D structure databases

ProteinModelPortaliQ94920.
SMRiQ94920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
InParanoidiQ94920.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ94920.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSYSDLG KQARDIFSKG YNFGLWKLDL KTKTSSGIEF NTAGHSNQES
60 70 80 90 100
GKVFGSLETK YKVKDYGLTL TEKWNTDNTL FTEVAVQDQL LEGLKLSLEG
110 120 130 140 150
NFAPQSGNKN GKFKVAYGHE NVKADSDVNI DLKGPLINAS AVLGYQGWLA
160 170 180 190 200
GYQTAFDTQQ SKLTTNNFAL GYTTKDFVLH TAVNDGQEFS GSIFQRTSDK
210 220 230 240 250
LDVGVQLSWA SGTSNTKFAI GAKYQLDDDA SVRAKVNNAS QVGLGYQQKL
260 270 280
RDGVTLTLST LVDGKNFNAG GHKIGVGLEL EA
Length:282
Mass (Da):30,550
Last modified:January 23, 2007 - v3
Checksum:i173E165C3A2D297D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231S → R in CAA63143 (PubMed:8797793).Curated1
Sequence conflicti231S → R in CAA64988 (PubMed:9688565).Curated1
Sequence conflicti252D → T in CAA63143 (PubMed:8797793).Curated1
Sequence conflicti252D → T in CAA64988 (PubMed:9688565).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70314 mRNA. Translation: AAC02635.1.
X92408 mRNA. Translation: CAA63143.1.
X95692 mRNA. Translation: CAA64988.1.
AJ000880 Genomic DNA. Translation: CAA04370.1.
AE014134 Genomic DNA. Translation: AAF53022.1.
AE014134 Genomic DNA. Translation: AAN10766.1.
AE014134 Genomic DNA. Translation: ABC65894.1.
AY070509 mRNA. Translation: AAL47980.1.
BT024247 mRNA. Translation: ABC86309.1.
RefSeqiNP_001033899.1. NM_001038810.2.
NP_001245961.1. NM_001259032.1.
NP_001260365.1. NM_001273436.1.
NP_476813.1. NM_057465.4.
NP_599110.1. NM_134283.2.
UniGeneiDm.33362.

Genome annotation databases

EnsemblMetazoaiFBtr0080182; FBpp0079771; FBgn0004363.
FBtr0080183; FBpp0079772; FBgn0004363.
FBtr0100584; FBpp0100039; FBgn0004363.
FBtr0305260; FBpp0293784; FBgn0004363.
FBtr0332029; FBpp0304343; FBgn0004363.
GeneIDi34500.
KEGGidme:Dmel_CG6647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70314 mRNA. Translation: AAC02635.1.
X92408 mRNA. Translation: CAA63143.1.
X95692 mRNA. Translation: CAA64988.1.
AJ000880 Genomic DNA. Translation: CAA04370.1.
AE014134 Genomic DNA. Translation: AAF53022.1.
AE014134 Genomic DNA. Translation: AAN10766.1.
AE014134 Genomic DNA. Translation: ABC65894.1.
AY070509 mRNA. Translation: AAL47980.1.
BT024247 mRNA. Translation: ABC86309.1.
RefSeqiNP_001033899.1. NM_001038810.2.
NP_001245961.1. NM_001259032.1.
NP_001260365.1. NM_001273436.1.
NP_476813.1. NM_057465.4.
NP_599110.1. NM_134283.2.
UniGeneiDm.33362.

3D structure databases

ProteinModelPortaliQ94920.
SMRiQ94920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60572. 70 interactors.
DIPiDIP-17501N.
IntActiQ94920. 5 interactors.
MINTiMINT-926159.
STRINGi7227.FBpp0079772.

Protein family/group databases

TCDBi1.B.8.1.6. the mitochondrial and plastid porin (mpp) family.

Proteomic databases

PaxDbiQ94920.
PRIDEiQ94920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080182; FBpp0079771; FBgn0004363.
FBtr0080183; FBpp0079772; FBgn0004363.
FBtr0100584; FBpp0100039; FBgn0004363.
FBtr0305260; FBpp0293784; FBgn0004363.
FBtr0332029; FBpp0304343; FBgn0004363.
GeneIDi34500.
KEGGidme:Dmel_CG6647.

Organism-specific databases

CTDi34500.
FlyBaseiFBgn0004363. porin.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
InParanoidiQ94920.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ94920.

Enzyme and pathway databases

ReactomeiR-DME-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

GenomeRNAii34500.
PROiQ94920.

Gene expression databases

BgeeiFBgn0004363.
ExpressionAtlasiQ94920. baseline.
GenevisibleiQ94920. DM.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC_DROME
AccessioniPrimary (citable) accession number: Q94920
Secondary accession number(s): Q29QZ3, Q94997, Q9VKP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.