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Protein

Voltage-dependent anion-selective channel

Gene

porin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei72 – 721Involved in hexokinase bindingBy similarity

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: FlyBase

GO - Biological processi

  • ion transport Source: FlyBase
  • mitochondrial transport Source: FlyBase
  • mitochondrion organization Source: FlyBase
  • phototransduction Source: FlyBase
  • regulation of anion transmembrane transport Source: GOC
  • regulation of cilium assembly Source: InterPro
  • sperm individualization Source: FlyBase
  • sperm mitochondrion organization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-5205685. Pink/Parkin Mediated Mitophagy.

Protein family/group databases

TCDBi1.B.8.1.6. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel
Alternative name(s):
DmVDAC
Porin
Gene namesi
Name:porin
Synonyms:POR-1, VDAC
ORF Names:CG6647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004363. porin.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • mitochondrial outer membrane Source: FlyBase
  • mitochondrion Source: FlyBase
  • Nebenkern Source: FlyBase
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 282281Voltage-dependent anion-selective channelPRO_0000050520Add
BLAST

Proteomic databases

PaxDbiQ94920.
PRIDEiQ94920.

Expressioni

Developmental stagei

Expressed throughout development, highest levels are in embryos and pupae.1 Publication

Gene expression databases

BgeeiQ94920.
ExpressionAtlasiQ94920. differential.
GenevisibleiQ94920. DM.

Interactioni

Subunit structurei

Interacts with hexokinases.By similarity

Protein-protein interaction databases

BioGridi60572. 70 interactions.
DIPiDIP-17501N.
IntActiQ94920. 5 interactions.
MINTiMINT-926159.
STRINGi7227.FBpp0079772.

Structurei

3D structure databases

ProteinModelPortaliQ94920.
SMRiQ94920. Positions 3-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
InParanoidiQ94920.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG7P8P8G.
PhylomeDBiQ94920.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSYSDLG KQARDIFSKG YNFGLWKLDL KTKTSSGIEF NTAGHSNQES
60 70 80 90 100
GKVFGSLETK YKVKDYGLTL TEKWNTDNTL FTEVAVQDQL LEGLKLSLEG
110 120 130 140 150
NFAPQSGNKN GKFKVAYGHE NVKADSDVNI DLKGPLINAS AVLGYQGWLA
160 170 180 190 200
GYQTAFDTQQ SKLTTNNFAL GYTTKDFVLH TAVNDGQEFS GSIFQRTSDK
210 220 230 240 250
LDVGVQLSWA SGTSNTKFAI GAKYQLDDDA SVRAKVNNAS QVGLGYQQKL
260 270 280
RDGVTLTLST LVDGKNFNAG GHKIGVGLEL EA
Length:282
Mass (Da):30,550
Last modified:January 23, 2007 - v3
Checksum:i173E165C3A2D297D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311S → R in CAA63143 (PubMed:8797793).Curated
Sequence conflicti231 – 2311S → R in CAA64988 (PubMed:9688565).Curated
Sequence conflicti252 – 2521D → T in CAA63143 (PubMed:8797793).Curated
Sequence conflicti252 – 2521D → T in CAA64988 (PubMed:9688565).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70314 mRNA. Translation: AAC02635.1.
X92408 mRNA. Translation: CAA63143.1.
X95692 mRNA. Translation: CAA64988.1.
AJ000880 Genomic DNA. Translation: CAA04370.1.
AE014134 Genomic DNA. Translation: AAF53022.1.
AE014134 Genomic DNA. Translation: AAN10766.1.
AE014134 Genomic DNA. Translation: ABC65894.1.
AY070509 mRNA. Translation: AAL47980.1.
BT024247 mRNA. Translation: ABC86309.1.
RefSeqiNP_001033899.1. NM_001038810.2.
NP_001245961.1. NM_001259032.1.
NP_001260365.1. NM_001273436.1.
NP_476813.1. NM_057465.4.
NP_599110.1. NM_134283.2.
UniGeneiDm.33362.

Genome annotation databases

EnsemblMetazoaiFBtr0080182; FBpp0079771; FBgn0004363.
FBtr0080183; FBpp0079772; FBgn0004363.
FBtr0100584; FBpp0100039; FBgn0004363.
FBtr0305260; FBpp0293784; FBgn0004363.
FBtr0332029; FBpp0304343; FBgn0004363.
GeneIDi34500.
KEGGidme:Dmel_CG6647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70314 mRNA. Translation: AAC02635.1.
X92408 mRNA. Translation: CAA63143.1.
X95692 mRNA. Translation: CAA64988.1.
AJ000880 Genomic DNA. Translation: CAA04370.1.
AE014134 Genomic DNA. Translation: AAF53022.1.
AE014134 Genomic DNA. Translation: AAN10766.1.
AE014134 Genomic DNA. Translation: ABC65894.1.
AY070509 mRNA. Translation: AAL47980.1.
BT024247 mRNA. Translation: ABC86309.1.
RefSeqiNP_001033899.1. NM_001038810.2.
NP_001245961.1. NM_001259032.1.
NP_001260365.1. NM_001273436.1.
NP_476813.1. NM_057465.4.
NP_599110.1. NM_134283.2.
UniGeneiDm.33362.

3D structure databases

ProteinModelPortaliQ94920.
SMRiQ94920. Positions 3-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60572. 70 interactions.
DIPiDIP-17501N.
IntActiQ94920. 5 interactions.
MINTiMINT-926159.
STRINGi7227.FBpp0079772.

Protein family/group databases

TCDBi1.B.8.1.6. the mitochondrial and plastid porin (mpp) family.

Proteomic databases

PaxDbiQ94920.
PRIDEiQ94920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080182; FBpp0079771; FBgn0004363.
FBtr0080183; FBpp0079772; FBgn0004363.
FBtr0100584; FBpp0100039; FBgn0004363.
FBtr0305260; FBpp0293784; FBgn0004363.
FBtr0332029; FBpp0304343; FBgn0004363.
GeneIDi34500.
KEGGidme:Dmel_CG6647.

Organism-specific databases

CTDi34500.
FlyBaseiFBgn0004363. porin.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
InParanoidiQ94920.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG7P8P8G.
PhylomeDBiQ94920.

Enzyme and pathway databases

ReactomeiR-DME-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

GenomeRNAii34500.
NextBioi788799.
PROiQ94920.

Gene expression databases

BgeeiQ94920.
ExpressionAtlasiQ94920. differential.
GenevisibleiQ94920. DM.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and molecular characterization of a voltage-dependent anion-selective channel (VDAC) from Drosophila melanogaster."
    Ryerse J.S., Blachly-Dyson E., Forte M.A., Nagel B.
    Biochim. Biophys. Acta 1327:204-212(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Canton-S.
    Tissue: Embryo.
  2. "Cloning and chromosomal localization of a cDNA encoding a mitochondrial porin from Drosophila melanogaster."
    Messina A., Neri M., Perosa F., Caggese C., Marino M., Caizzi R., De Pinto V.
    FEBS Lett. 384:9-13(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-10.
    Strain: Oregon-R.
    Tissue: Head.
  3. "Sequence and expression pattern of the Drosophila melanogaster mitochondrial porin gene: evidence of a conserved protein domain between fly and mouse."
    Oliva M., Messina A., Ragone G., Caggese C., De Pinto V.
    FEBS Lett. 430:327-332(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
    Tissue: Larva.
  4. "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database."
    Caggese C., Ragone G., Perrini B., Moschetti R., de Pinto V., Caizzi R., Barsanti P.
    Mol. Gen. Genet. 261:64-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Ovary.
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  8. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.

Entry informationi

Entry nameiVDAC_DROME
AccessioniPrimary (citable) accession number: Q94920
Secondary accession number(s): Q29QZ3, Q94997, Q9VKP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.