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Protein

RNA-binding protein lark

Gene

lark

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 185CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • circadian rhythm Source: FlyBase
  • cytoplasmic transport, nurse cell to oocyte Source: UniProtKB
  • eclosion Source: FlyBase
  • eclosion rhythm Source: UniProtKB
  • embryo development Source: UniProtKB
  • locomotor rhythm Source: FlyBase
  • mitotic nuclear division Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • negative regulation of eclosion Source: UniProtKB
  • protein localization Source: UniProtKB
  • regulation of embryonic development Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein lark
Gene namesi
Name:lark
ORF Names:CG8597
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011640. lark.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: The precise location within neurons varies according to the type of neuron, being cytoplasmic in CCAP neurons and nuclear in the CNS.

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: FlyBase
  • cytoplasm Source: UniProtKB
  • cytosol Source: GOC
  • nucleus Source: UniProtKB
  • precatalytic spliceosome Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10F → A: Non-functional; when associated with A-89. 1 Publication1
Mutagenesisi89F → A: Defects in sensory bristle formation and wing shape, and oogenesis. Non-functional; when associated with A-10. 1 Publication1
Mutagenesisi170C → Y: Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-173. 1 Publication1
Mutagenesisi173C → Y: Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-170. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817581 – 352RNA-binding protein larkAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198Phosphoserine1 Publication1
Modified residuei201Phosphoserine1 Publication1
Modified residuei315Phosphoserine1 Publication1
Modified residuei325Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ94901.
PRIDEiQ94901.

PTM databases

iPTMnetiQ94901.

Expressioni

Tissue specificityi

Expressed in the CNS and in CCAP neurons of the ventral nervous system (VNS), which control insect ecdysis.2 Publications

Inductioni

Oscillates in abundance during the circadian cycle at the protein level; peaks during the subjective day.1 Publication

Gene expression databases

BgeeiFBgn0011640.
GenevisibleiQ94901. DM.

Interactioni

Protein-protein interaction databases

BioGridi64251. 22 interactors.
MINTiMINT-786921.
STRINGi7227.FBpp0076555.

Structurei

3D structure databases

ProteinModelPortaliQ94901.
SMRiQ94901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 77RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini86 – 156RRM 2PROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 223Poly-Pro10
Compositional biasi263 – 266Poly-Pro4
Compositional biasi301 – 304Poly-Pro4

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 185CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0109. Eukaryota.
ENOG41105PP. LUCA.
GeneTreeiENSGT00390000020883.
InParanoidiQ94901.
KOiK13187.
OMAiMKVQIST.
OrthoDBiEOG091G0JQC.
PhylomeDBiQ94901.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAGTFKLF IGNLDEKTQA TELRALFEKY GTVVECDVVK NYGFVHMETE
60 70 80 90 100
QQGRDAIQNL NGYTLNEFAI KVEAAKSRRA PNTPTTKIFV GNLTDKTRAP
110 120 130 140 150
EVRELFQKYG TVVECDIVRN YGFVHLDCVG DVQDAIKELN GRVVDGQPLK
160 170 180 190 200
VQVSTSRVRP KPGMGDPEQC YRCGRSGHWS KECPRLYGSA GGGREPPSPL
210 220 230 240 250
SAGGYRDRMY GRDPYPPPPP PPPFLRDRIM DGFRDYDYYD RRFEDSRDLY
260 270 280 290 300
ERRYQTSRMR DFPPPPISRR EPMPLPPTLS GSLRSCSVSR GYDTMFSRRS
310 320 330 340 350
PPPPRSSNGM SRYGSPTPHG YEDFSRDAFD ERMISSRGMR GPSPPGRRYA

PY
Length:352
Mass (Da):39,912
Last modified:February 1, 1997 - v1
Checksum:iC8D698D4DD122FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59476 mRNA. Translation: AAB07067.1.
AE014296 Genomic DNA. Translation: AAF50578.1.
AE014296 Genomic DNA. Translation: AAN12053.1.
AE014296 Genomic DNA. Translation: AAN12054.1.
AE014296 Genomic DNA. Translation: AAN12055.1.
AE014296 Genomic DNA. Translation: AAN12056.1.
AY061458 mRNA. Translation: AAL29006.1.
RefSeqiNP_523957.1. NM_079233.6.
NP_729237.1. NM_168202.3.
NP_729238.1. NM_168203.4.
NP_729239.1. NM_168204.3.
NP_729240.1. NM_168205.4.
UniGeneiDm.7078.

Genome annotation databases

EnsemblMetazoaiFBtr0076841; FBpp0076552; FBgn0011640.
FBtr0076842; FBpp0076553; FBgn0011640.
FBtr0076843; FBpp0076554; FBgn0011640.
FBtr0076844; FBpp0076555; FBgn0011640.
FBtr0076845; FBpp0076556; FBgn0011640.
GeneIDi38811.
KEGGidme:Dmel_CG8597.
UCSCiCG8597-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59476 mRNA. Translation: AAB07067.1.
AE014296 Genomic DNA. Translation: AAF50578.1.
AE014296 Genomic DNA. Translation: AAN12053.1.
AE014296 Genomic DNA. Translation: AAN12054.1.
AE014296 Genomic DNA. Translation: AAN12055.1.
AE014296 Genomic DNA. Translation: AAN12056.1.
AY061458 mRNA. Translation: AAL29006.1.
RefSeqiNP_523957.1. NM_079233.6.
NP_729237.1. NM_168202.3.
NP_729238.1. NM_168203.4.
NP_729239.1. NM_168204.3.
NP_729240.1. NM_168205.4.
UniGeneiDm.7078.

3D structure databases

ProteinModelPortaliQ94901.
SMRiQ94901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64251. 22 interactors.
MINTiMINT-786921.
STRINGi7227.FBpp0076555.

PTM databases

iPTMnetiQ94901.

Proteomic databases

PaxDbiQ94901.
PRIDEiQ94901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076841; FBpp0076552; FBgn0011640.
FBtr0076842; FBpp0076553; FBgn0011640.
FBtr0076843; FBpp0076554; FBgn0011640.
FBtr0076844; FBpp0076555; FBgn0011640.
FBtr0076845; FBpp0076556; FBgn0011640.
GeneIDi38811.
KEGGidme:Dmel_CG8597.
UCSCiCG8597-RA. d. melanogaster.

Organism-specific databases

CTDi38811.
FlyBaseiFBgn0011640. lark.

Phylogenomic databases

eggNOGiKOG0109. Eukaryota.
ENOG41105PP. LUCA.
GeneTreeiENSGT00390000020883.
InParanoidiQ94901.
KOiK13187.
OMAiMKVQIST.
OrthoDBiEOG091G0JQC.
PhylomeDBiQ94901.

Miscellaneous databases

GenomeRNAii38811.
PROiQ94901.

Gene expression databases

BgeeiFBgn0011640.
GenevisibleiQ94901. DM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLARK_DROME
AccessioniPrimary (citable) accession number: Q94901
Secondary accession number(s): A4V1L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.