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Protein

Isomultiflorenol synthase

Gene

IMS1

Organism
Luffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase involved in the biosynthesis of bryonolic acid. Converts oxidosqualene to isomultiflorenol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = isomultiflorenol.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.4.99.36. 3083.

Names & Taxonomyi

Protein namesi
Recommended name:
Isomultiflorenol synthase (EC:5.4.99.36)
Short name:
LcIMS1
Gene namesi
Name:IMS1
OrganismiLuffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
Taxonomic identifieri3670 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeSicyoeaeLuffa

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004129911 – 759Isomultiflorenol synthaseAdd BLAST759

Structurei

3D structure databases

ProteinModelPortaliQ948R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 189PFTB 1Add BLAST42
Repeati588 – 628PFTB 2Add BLAST41
Repeati637 – 678PFTB 3Add BLAST42
Repeati699 – 743PFTB 4Add BLAST45

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK15820.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q948R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLKVADGG NDPYIYSMNN FIGRQIWEFD PNAGTPEERA EIERLRHHFT
60 70 80 90 100
KNRHKGFPSA DLLWRVQLLR EKNFKQSIPA VKVGDGEEIS YEMALDAMRR
110 120 130 140 150
GAHFLAAIQA SDGHWPSETS GPLFYVCPLL ICMYIMGFMD KVFSPEHKKE
160 170 180 190 200
MMRYIYNHQN EDGGWGLHVG GHSNMFCTTF NYISLRLLGE EPDVEAVCKA
210 220 230 240 250
RNWIHDHDGV TSILSWGKTW LSILNVFDWS ASNPMPPEYW MLPTWVPIHP
260 270 280 290 300
SNMMCYTRIT YMPMSYLYGK RFQAPLTPLV LQLRDELHTQ PYDQINWRKV
310 320 330 340 350
RHMCATEDLY FPHPFVQDLL WDTLYLLSEP LMTRWPFNKL IRQKALNETM
360 370 380 390 400
RHIHYEDENS RYITIGCVEK PLCMLACWVE DPNSEYVKKH LARIPDYLWM
410 420 430 440 450
AEDGMKMQSF GSQSWDAALA MQALLSCNIT REIGSVLNSG HDFIKNSQVR
460 470 480 490 500
NNPPGDYKSM FRYMSKGSWT FSDCDHGWQV SDCTAENLKC CLLLSLLPPD
510 520 530 540 550
IVGEKMEPER FYDAVNVILN MQSKNGGLPA WEPASSYYWM EWLNPVEFLE
560 570 580 590 600
DLIIEHQHVE CTSSALQAIL LFRKQYPGHR RKEINNFINK AVQFLQDIQL
610 620 630 640 650
PDGSWYGNWG ICYTYGTWFA LKALSMAGKT YENCEAVRKG ANFLRKIQNP
660 670 680 690 700
EGGFGESYLS CPYKRYIPLD GKRSNLVQTA WGMMGLICAG QADVDPTPIH
710 720 730 740 750
RAAKLLINSQ TEDGDFPQEE ITGEFFKNCT LHFAAFREVF PVMALGEYCN

KVPLPSKKK
Length:759
Mass (Da):87,840
Last modified:December 1, 2001 - v1
Checksum:i8215E88FB3A43359
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058643 mRNA. Translation: BAB68529.1.

Genome annotation databases

KEGGiag:BAB68529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058643 mRNA. Translation: BAB68529.1.

3D structure databases

ProteinModelPortaliQ948R6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:BAB68529.

Phylogenomic databases

KOiK15820.

Enzyme and pathway databases

BRENDAi5.4.99.36. 3083.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMFS_LUFAE
AccessioniPrimary (citable) accession number: Q948R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

In cultured cells, IMS1 mRNA expression is high between days 16 and 20 and precedes the accumulation of bryonolic acid.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.