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Q948R6

- IMFS_LUFAE

UniProt

Q948R6 - IMFS_LUFAE

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Protein

Isomultiflorenol synthase

Gene
IMS1
Organism
Luffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase involved in the biosynthesis of bryonolic acid. Converts oxidosqualene to isomultiflorenol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = isomultiflorenol.1 Publication

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Isomultiflorenol synthase (EC:5.4.99.36)
Short name:
LcIMS1
Gene namesi
Name:IMS1
OrganismiLuffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
Taxonomic identifieri3670 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeSicyoeaeLuffa

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Isomultiflorenol synthasePRO_0000412991Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ948R6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1Add
BLAST
Repeati588 – 62841PFTB 2Add
BLAST
Repeati637 – 67842PFTB 3Add
BLAST
Repeati699 – 74345PFTB 4Add
BLAST

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q948R6-1 [UniParc]FASTAAdd to Basket

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MWRLKVADGG NDPYIYSMNN FIGRQIWEFD PNAGTPEERA EIERLRHHFT    50
KNRHKGFPSA DLLWRVQLLR EKNFKQSIPA VKVGDGEEIS YEMALDAMRR 100
GAHFLAAIQA SDGHWPSETS GPLFYVCPLL ICMYIMGFMD KVFSPEHKKE 150
MMRYIYNHQN EDGGWGLHVG GHSNMFCTTF NYISLRLLGE EPDVEAVCKA 200
RNWIHDHDGV TSILSWGKTW LSILNVFDWS ASNPMPPEYW MLPTWVPIHP 250
SNMMCYTRIT YMPMSYLYGK RFQAPLTPLV LQLRDELHTQ PYDQINWRKV 300
RHMCATEDLY FPHPFVQDLL WDTLYLLSEP LMTRWPFNKL IRQKALNETM 350
RHIHYEDENS RYITIGCVEK PLCMLACWVE DPNSEYVKKH LARIPDYLWM 400
AEDGMKMQSF GSQSWDAALA MQALLSCNIT REIGSVLNSG HDFIKNSQVR 450
NNPPGDYKSM FRYMSKGSWT FSDCDHGWQV SDCTAENLKC CLLLSLLPPD 500
IVGEKMEPER FYDAVNVILN MQSKNGGLPA WEPASSYYWM EWLNPVEFLE 550
DLIIEHQHVE CTSSALQAIL LFRKQYPGHR RKEINNFINK AVQFLQDIQL 600
PDGSWYGNWG ICYTYGTWFA LKALSMAGKT YENCEAVRKG ANFLRKIQNP 650
EGGFGESYLS CPYKRYIPLD GKRSNLVQTA WGMMGLICAG QADVDPTPIH 700
RAAKLLINSQ TEDGDFPQEE ITGEFFKNCT LHFAAFREVF PVMALGEYCN 750
KVPLPSKKK 759
Length:759
Mass (Da):87,840
Last modified:December 1, 2001 - v1
Checksum:i8215E88FB3A43359
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058643 mRNA. Translation: BAB68529.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058643 mRNA. Translation: BAB68529.1 .

3D structure databases

ProteinModelPortali Q948R6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid."
    Hayashi H., Huang P., Inoue K., Hiraoka N., Ikeshiro Y., Yazaki K., Tanaka S., Kushiro T., Shibuya M., Ebizuka Y.
    Eur. J. Biochem. 268:6311-6317(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, INDUCTION.

Entry informationi

Entry nameiIMFS_LUFAE
AccessioniPrimary (citable) accession number: Q948R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

In cultured cells, IMS1 mRNA expression is high between days 16 and 20 and precedes the accumulation of bryonolic acid.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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