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Q948R6

- IMFS_LUFAE

UniProt

Q948R6 - IMFS_LUFAE

Protein

Isomultiflorenol synthase

Gene

IMS1

Organism
Luffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Oxidosqualene cyclase involved in the biosynthesis of bryonolic acid. Converts oxidosqualene to isomultiflorenol.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = isomultiflorenol.1 Publication

    GO - Molecular functioni

    1. intramolecular transferase activity Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isomultiflorenol synthase (EC:5.4.99.36)
    Short name:
    LcIMS1
    Gene namesi
    Name:IMS1
    OrganismiLuffa aegyptiaca (Sponge gourd) (Luffa cylindrica)
    Taxonomic identifieri3670 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeSicyoeaeLuffa

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Isomultiflorenol synthasePRO_0000412991Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ948R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati148 – 18942PFTB 1Add
    BLAST
    Repeati588 – 62841PFTB 2Add
    BLAST
    Repeati637 – 67842PFTB 3Add
    BLAST
    Repeati699 – 74345PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q948R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRLKVADGG NDPYIYSMNN FIGRQIWEFD PNAGTPEERA EIERLRHHFT    50
    KNRHKGFPSA DLLWRVQLLR EKNFKQSIPA VKVGDGEEIS YEMALDAMRR 100
    GAHFLAAIQA SDGHWPSETS GPLFYVCPLL ICMYIMGFMD KVFSPEHKKE 150
    MMRYIYNHQN EDGGWGLHVG GHSNMFCTTF NYISLRLLGE EPDVEAVCKA 200
    RNWIHDHDGV TSILSWGKTW LSILNVFDWS ASNPMPPEYW MLPTWVPIHP 250
    SNMMCYTRIT YMPMSYLYGK RFQAPLTPLV LQLRDELHTQ PYDQINWRKV 300
    RHMCATEDLY FPHPFVQDLL WDTLYLLSEP LMTRWPFNKL IRQKALNETM 350
    RHIHYEDENS RYITIGCVEK PLCMLACWVE DPNSEYVKKH LARIPDYLWM 400
    AEDGMKMQSF GSQSWDAALA MQALLSCNIT REIGSVLNSG HDFIKNSQVR 450
    NNPPGDYKSM FRYMSKGSWT FSDCDHGWQV SDCTAENLKC CLLLSLLPPD 500
    IVGEKMEPER FYDAVNVILN MQSKNGGLPA WEPASSYYWM EWLNPVEFLE 550
    DLIIEHQHVE CTSSALQAIL LFRKQYPGHR RKEINNFINK AVQFLQDIQL 600
    PDGSWYGNWG ICYTYGTWFA LKALSMAGKT YENCEAVRKG ANFLRKIQNP 650
    EGGFGESYLS CPYKRYIPLD GKRSNLVQTA WGMMGLICAG QADVDPTPIH 700
    RAAKLLINSQ TEDGDFPQEE ITGEFFKNCT LHFAAFREVF PVMALGEYCN 750
    KVPLPSKKK 759
    Length:759
    Mass (Da):87,840
    Last modified:December 1, 2001 - v1
    Checksum:i8215E88FB3A43359
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058643 mRNA. Translation: BAB68529.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058643 mRNA. Translation: BAB68529.1 .

    3D structure databases

    ProteinModelPortali Q948R6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid."
      Hayashi H., Huang P., Inoue K., Hiraoka N., Ikeshiro Y., Yazaki K., Tanaka S., Kushiro T., Shibuya M., Ebizuka Y.
      Eur. J. Biochem. 268:6311-6317(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, INDUCTION.

    Entry informationi

    Entry nameiIMFS_LUFAE
    AccessioniPrimary (citable) accession number: Q948R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In cultured cells, IMS1 mRNA expression is high between days 16 and 20 and precedes the accumulation of bryonolic acid.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3