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Protein

Ferritin-4, chloroplastic

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron 1PROSITE-ProRule annotation
Metal bindingi126 – 1261Iron 1PROSITE-ProRule annotation
Metal bindingi126 – 1261Iron 2PROSITE-ProRule annotation
Metal bindingi129 – 1291Iron 1PROSITE-ProRule annotation
Metal bindingi175 – 1751Iron 2PROSITE-ProRule annotation
Metal bindingi209 – 2091Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-4, chloroplastic (EC:1.16.3.1)
Alternative name(s):
SFerH-4
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 14

Subcellular locationi

Plastidchloroplast By similarity

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040ChloroplastSequence AnalysisAdd
BLAST
Chaini41 – 247207Ferritin-4, chloroplasticPRO_0000008867Add
BLAST

Proteomic databases

PRIDEiQ948P5.

Expressioni

Gene expression databases

GenevestigatoriQ948P5.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

Secondary structure

1
247
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 565Combined sources
Turni57 – 626Combined sources
Helixi78 – 10528Combined sources
Turni108 – 1103Combined sources
Helixi113 – 14028Combined sources
Turni159 – 1613Combined sources
Helixi163 – 19129Combined sources
Helixi195 – 20410Combined sources
Helixi206 – 22621Combined sources
Helixi230 – 24011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A68X-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X36-247[»]
3A9QX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X36-247[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ948P5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 227154Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 7333Extension peptide (EP)Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ948P5.
KOiK00522.
OMAiYLAMAFH.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q948P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRTAAASA SSLSLFSPNA EPPRSVPARG LVVRAAKGST NHRALTGVIF
60 70 80 90 100
EPFEEVKKEL DLVPTVPQAS LARQKYVDES ESAVNEQINV EYNVSYVYHA
110 120 130 140 150
MFAYFDRDNV ALRGLAKFFK ESSEEEREHA EKLMEYQNKR GGKVKLQSIV
160 170 180 190 200
MPLSDFDHAD KGDALHAMEL ALSLEKLTNE KLLNLHSVAT KNGDVQLADF
210 220 230 240
VETEYLGEQV EAIKRISEYV AQLRRVGKGH GVWHFDQMLL HEGGDAA
Length:247
Mass (Da):27,559
Last modified:September 21, 2009 - v2
Checksum:i9A643DDFB5DDEDE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062756 mRNA. Translation: BAB64537.2.
RefSeqiNP_001237049.1. NM_001250120.1.
UniGeneiGma.18301.

Genome annotation databases

EnsemblPlantsiGLYMA14G06160.1; GLYMA14G06160.1; GLYMA14G06160.
GeneIDi547477.
KEGGigmx:547477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062756 mRNA. Translation: BAB64537.2.
RefSeqiNP_001237049.1. NM_001250120.1.
UniGeneiGma.18301.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A68X-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X36-247[»]
3A9QX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X36-247[»]
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ948P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA14G06160.1; GLYMA14G06160.1; GLYMA14G06160.
GeneIDi547477.
KEGGigmx:547477.

Phylogenomic databases

InParanoidiQ948P5.
KOiK00522.
OMAiYLAMAFH.

Miscellaneous databases

EvolutionaryTraceiQ948P5.

Gene expression databases

GenevestigatoriQ948P5.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Construction of homo- and heteropolymers of plant ferritin subunits using an in vitro protein expression system."
    Masuda T., Goto F., Yoshihara T., Ezure T., Suzuki T., Kobayashi S., Shikata M., Utsumi S.
    Protein Expr. Purif. 56:237-246(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFRI4_SOYBN
AccessioniPrimary (citable) accession number: Q948P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 10, 2003
Last sequence update: September 21, 2009
Last modified: January 6, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.