Q94883 (Q94883_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA replication-related element factor EMBL AAF52841.1

Submitted name:
DREF EMBL BAA24827.1
Submitted name:
FI03642p EMBL ACV53073.1

Gene names

Name:	Dref FlyBase FBgn0015664
Synonyms:	Dref-RA EMBL ACV53073.1
ORF Names:	CG5838 FlyBase FBgn0015664, Dmel_CG5838 EMBL AAF52841.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA endoreduplication Inferred from mutant phenotype. Source: FlyBase chaeta development Inferred from mutant phenotype. Source: FlyBase compound eye morphogenesis Inferred from mutant phenotype. Source: FlyBase mitochondrial DNA replication Traceable author statement. Source: FlyBase mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase protein autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB regulation of DNA biosynthetic process Inferred from direct assay. Source: FlyBase regulation of apoptotic process Inferred from direct assay. Source: FlyBase regulation of cell cycle Non-traceable author statement. Source: FlyBase regulation of cell proliferation involved in compound eye morphogenesis Inferred from direct assay. Source: FlyBase regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: FlyBase sensory organ precursor cell division Inferred from mutant phenotype. Source: FlyBase
Cellular component	mitochondrion Traceable author statement. Source: GOC transcription factor complex Inferred from physical interaction. Source: FlyBase
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Traceable author statement. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q94883 [UniParc]. Last modified June 1, 1998. Version 2. Checksum: E462D778AE28714F	FASTA	709	80,727
	10 20 30 40 50 60 MSEGVPASPV AIGELKYEDV SQLNFSKLYS PKMKSVYWRY FGFPSNDNNE VITKQNVVCI 70 80 90 100 110 120 KCHKVLTNHG NTTNLRAHLQ HRHKDLFKEL CQEHDIHVPP RKTPRNVSHP PLSKRNVSSR 130 140 150 160 170 180 RVKLEFINNR NHDNASDDEL DEAAVATAAM QAEEDASSQT MLYETMVPFT YDEAENLVEE 190 200 210 220 230 240 EERLVMEPKY GRKRKVATPS SALMHGRVIK HEEGGYAAVA NIANLAEALT DIVIKDLRNV 250 260 270 280 290 300 DSLYDAGFGE FLRQVLGNSA AMPEPHKIDS LINEMHASKF LEIGEITRDF TSEKPFSLAF 310 320 330 340 350 360 EMWVNVEQRR FLSIFHHFLD EETHSVRGML YATVEYNDYI VFDDLLTDFY LANCTLAIIN 370 380 390 400 410 420 YDEEEDLLHT YLREKNIPIS LCYVSVIDKC LRRVFEIEEV ATLLEQVKDL MQRHSTEIAS 430 440 450 460 470 480 KVSEVPMPTY NEHFPWTLYE TLKFFAESIS WSEDMDHLVI SAKTVTEALS ALVIALDTLR 490 500 510 520 530 540 GEDIPLCSML SPITSKILIK KLGIAEQDDP LMMNLKRTIS SVLQAHVISN DNLTAAALLD 550 560 570 580 590 600 PRFHRLTTID NLERTVRMLT HKYNINFGGV GEGESNEVAA TSSVVAIKSE PRVVDGSAPK 610 620 630 640 650 660 KLGLKLLFDS NEIPNPPKRD ADSSVESDLK RYRNEVVVQL DESPIEWWLK MGHIYGTLRD 670 680 690 700 LASLYHSVPG VVTLSFKKAL RDQIYDFNKR FMLTGSHIDA ILFLHHHNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of cDNA for DREF, a promoter-activating factor for Drosophila DNA replication-related genes." Hirose F., Yamaguchi M., Kuroda K., Omori A., Hachiya T., Ikeda M., Nishimoto Y., Matsukage A. J. Biol. Chem. 271:3930-3937(1996) [PubMed: 8632015] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton S EMBL BAA24827.1.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Identification of three conserved regions in the DREF transcription factors from Drosophila melanogaster and Drosophila virilis." Takahashi Y., Hirose F., Matsukage A., Yamaguchi M. Nucleic Acids Res. 27:510-516(1999) [PubMed: 9862973] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton S EMBL BAA24827.1.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[5]	Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: AAF52841.1. BT099709 mRNA. Translation: ACV53073.1. AB010823 mRNA. Translation: BAA24827.1.
PIR	T00096.
RefSeq	NP_523529.1. NM_078805.3.
UniGene	Dm.7169.
3D structure databases
ProteinModelPortal	Q94883.
SMR	Q94883. Positions 31-95.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-22338N.
IntAct	Q94883. 3 interactions.
MINT	MINT-744084.
STRING	Q94883.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0079889; FBpp0079485; FBgn0015664.
GeneID	34328.
KEGG	dme:Dmel_CG5838.
NMPDR	fig|7227.3.peg.1693.
UCSC	CG5838-RA. d. melanogaster.
Organism-specific databases
CTD	34328.
FlyBase	FBgn0015664. Dref.
Phylogenomic databases
GeneTree	EMGT00050000012704.
InParanoid	Q94883.
OMA	DESPIEW.
PhylomeDB	Q94883.
Gene expression databases
ArrayExpress	Q94883.
Bgee	Q94883.
Family and domain databases
InterPro	IPR012337. RNaseH-like_dom. IPR003656. Znf_BED_prd. [Graphical view]
Pfam	PF02892. zf-BED. 1 hit. [Graphical view]
SMART	SM00614. ZnF_BED. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS50808. ZF_BED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	787970.

Entry information

Entry name

Q94883_DROME

Accession

Primary (citable) accession number: Q94883

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)